AlphaFold2 and RoseTTAFold predict posttranslational modifications. Chromophore formation in GFP-like proteins

AlphaFold2 and RoseTTAfold are able to predict, based solely on their sequence whether GFP-like proteins will post-translationally form a chromophore (the part of the protein responsible for fluorescence) or not. Their training has not only taught them protein structure and folding, but also chemist...

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Veröffentlicht in:	PloS one 2022-06, Vol.17 (6), p.e0267560-e0267560
Hauptverfasser:	Hartley, Sophia M, Tiernan, Kelly A, Ahmetaj, Gjina, Cretu, Adriana, Zhuang, Yan, Zimmer, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Binding sites Biology and Life Sciences Chromophores Crystal structure Fluorescence Green fluorescent protein Helices Hydrogen bonds Peptides Physical Sciences Post-translation Post-translational modification Protein folding Protein research Protein structure Protein structure prediction Proteins Residues Sequences Statistical analysis Structure
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