The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis
The incidence of childhood ALL in Indonesia is still largely unknown. The widely mentioned statistics from other countries turn out to be only estimated figures. Other data do not specify the types of leukemia and are not specifically focused on children. Therefore, this study aims to pool incidence...
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| description | The incidence of childhood ALL in Indonesia is still largely unknown. The widely mentioned statistics from other countries turn out to be only estimated figures. Other data do not specify the types of leukemia and are not specifically focused on children. Therefore, this study aims to pool incidence and mortality statistics from available studies in Indonesia.
We searched five different academic databases, including Pubmed, MEDLINE, Cochrane Library, Science Direct, and Google Scholar. Three Indonesian databases, such as the Indonesian Scientific Journal Database (ISJD), Neliti, and Indonesia One Search, were also utilized. Incidence was expressed as per 100,000 children. We used the Newcastle-Ottawa scale (NOS) to assess the quality of cohort studies. The inclusion criteria are cohort studies published in the languages of English or Indonesian. For this analysis, we define children as 0-18 years old.
The incidence rate for childhood ALL was found to be 4.32 per 100,000 children (95% CI 2.65-5.99) with a prediction interval of 1.98 to 9.42 per 100,000 children. The incidence rate is higher in males, with 2.45 per 100,000 children (95% CI 1.98-2.91) and a prediction interval of 1.90 to 3.16 per 100,000 children. As for females, the incidence rate is 2.05 per 100,000 children (95% CI 1.52-2.77) with a prediction interval of 1.52 to 2.77 per 100,000 children. The mortality of childhood ALL ranges from 0.44 to 5.3 deaths per 100,000 children, while the CFR is 3.58% with varying true effect sizes of 2.84% to 4.52%.
With 79.5 million children living in Indonesia in 2018, this means that there were roughly 3,434 new cases of childhood ALL. An organized effort between multiple sectors is needed to improve the registries of childhood ALL in Indonesia. |
| doi_str_mv | 10.1371/journal.pone.0269706 |
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We searched five different academic databases, including Pubmed, MEDLINE, Cochrane Library, Science Direct, and Google Scholar. Three Indonesian databases, such as the Indonesian Scientific Journal Database (ISJD), Neliti, and Indonesia One Search, were also utilized. Incidence was expressed as per 100,000 children. We used the Newcastle-Ottawa scale (NOS) to assess the quality of cohort studies. The inclusion criteria are cohort studies published in the languages of English or Indonesian. For this analysis, we define children as 0-18 years old.
The incidence rate for childhood ALL was found to be 4.32 per 100,000 children (95% CI 2.65-5.99) with a prediction interval of 1.98 to 9.42 per 100,000 children. The incidence rate is higher in males, with 2.45 per 100,000 children (95% CI 1.98-2.91) and a prediction interval of 1.90 to 3.16 per 100,000 children. As for females, the incidence rate is 2.05 per 100,000 children (95% CI 1.52-2.77) with a prediction interval of 1.52 to 2.77 per 100,000 children. The mortality of childhood ALL ranges from 0.44 to 5.3 deaths per 100,000 children, while the CFR is 3.58% with varying true effect sizes of 2.84% to 4.52%.
With 79.5 million children living in Indonesia in 2018, this means that there were roughly 3,434 new cases of childhood ALL. An organized effort between multiple sectors is needed to improve the registries of childhood ALL in Indonesia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0269706</identifier><identifier>PMID: 35696384</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Adolescent ; Biology and Life Sciences ; Cancer ; Child ; Child, Preschool ; Childhood ; Children ; Cohort Studies ; Diagnosis ; Disease ; Diseases ; Distribution ; Epidemiology ; Fatalities ; Female ; Health care policy ; Humans ; Incidence ; Indonesia - epidemiology ; Infant ; Infant, Newborn ; Leukemia ; Male ; Medicine and Health Sciences ; Meta-analysis ; Mortality ; People and Places ; Physical Sciences ; Population ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology ; Predictions ; Quality assessment ; Registries ; Research and Analysis Methods ; Statistical analysis ; Systematic review</subject><ispartof>PloS one, 2022-06, Vol.17 (6), p.e0269706</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Garniasih et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Garniasih et al 2022 Garniasih et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-68f6ef491aab63d94309cb2dd31b4535763635085a9f99cf36a23fe234cb90c63</citedby><cites>FETCH-LOGICAL-c692t-68f6ef491aab63d94309cb2dd31b4535763635085a9f99cf36a23fe234cb90c63</cites><orcidid>0000-0003-2437-6478</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191700/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191700/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35696384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garniasih, Dina</creatorcontrib><creatorcontrib>Susanah, Susi</creatorcontrib><creatorcontrib>Sribudiani, Yunia</creatorcontrib><creatorcontrib>Hilmanto, Dany</creatorcontrib><title>The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The incidence of childhood ALL in Indonesia is still largely unknown. The widely mentioned statistics from other countries turn out to be only estimated figures. Other data do not specify the types of leukemia and are not specifically focused on children. Therefore, this study aims to pool incidence and mortality statistics from available studies in Indonesia.
We searched five different academic databases, including Pubmed, MEDLINE, Cochrane Library, Science Direct, and Google Scholar. Three Indonesian databases, such as the Indonesian Scientific Journal Database (ISJD), Neliti, and Indonesia One Search, were also utilized. Incidence was expressed as per 100,000 children. We used the Newcastle-Ottawa scale (NOS) to assess the quality of cohort studies. The inclusion criteria are cohort studies published in the languages of English or Indonesian. For this analysis, we define children as 0-18 years old.
The incidence rate for childhood ALL was found to be 4.32 per 100,000 children (95% CI 2.65-5.99) with a prediction interval of 1.98 to 9.42 per 100,000 children. The incidence rate is higher in males, with 2.45 per 100,000 children (95% CI 1.98-2.91) and a prediction interval of 1.90 to 3.16 per 100,000 children. As for females, the incidence rate is 2.05 per 100,000 children (95% CI 1.52-2.77) with a prediction interval of 1.52 to 2.77 per 100,000 children. The mortality of childhood ALL ranges from 0.44 to 5.3 deaths per 100,000 children, while the CFR is 3.58% with varying true effect sizes of 2.84% to 4.52%.
With 79.5 million children living in Indonesia in 2018, this means that there were roughly 3,434 new cases of childhood ALL. An organized effort between multiple sectors is needed to improve the registries of childhood ALL in Indonesia.</description><subject>Acute lymphoblastic leukemia</subject><subject>Acute lymphocytic leukemia</subject><subject>Adolescent</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Diseases</subject><subject>Distribution</subject><subject>Epidemiology</subject><subject>Fatalities</subject><subject>Female</subject><subject>Health care policy</subject><subject>Humans</subject><subject>Incidence</subject><subject>Indonesia - epidemiology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Leukemia</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garniasih, Dina</au><au>Susanah, Susi</au><au>Sribudiani, Yunia</au><au>Hilmanto, Dany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-06-13</date><risdate>2022</risdate><volume>17</volume><issue>6</issue><spage>e0269706</spage><pages>e0269706-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The incidence of childhood ALL in Indonesia is still largely unknown. The widely mentioned statistics from other countries turn out to be only estimated figures. Other data do not specify the types of leukemia and are not specifically focused on children. Therefore, this study aims to pool incidence and mortality statistics from available studies in Indonesia.
We searched five different academic databases, including Pubmed, MEDLINE, Cochrane Library, Science Direct, and Google Scholar. Three Indonesian databases, such as the Indonesian Scientific Journal Database (ISJD), Neliti, and Indonesia One Search, were also utilized. Incidence was expressed as per 100,000 children. We used the Newcastle-Ottawa scale (NOS) to assess the quality of cohort studies. The inclusion criteria are cohort studies published in the languages of English or Indonesian. For this analysis, we define children as 0-18 years old.
The incidence rate for childhood ALL was found to be 4.32 per 100,000 children (95% CI 2.65-5.99) with a prediction interval of 1.98 to 9.42 per 100,000 children. The incidence rate is higher in males, with 2.45 per 100,000 children (95% CI 1.98-2.91) and a prediction interval of 1.90 to 3.16 per 100,000 children. As for females, the incidence rate is 2.05 per 100,000 children (95% CI 1.52-2.77) with a prediction interval of 1.52 to 2.77 per 100,000 children. The mortality of childhood ALL ranges from 0.44 to 5.3 deaths per 100,000 children, while the CFR is 3.58% with varying true effect sizes of 2.84% to 4.52%.
With 79.5 million children living in Indonesia in 2018, this means that there were roughly 3,434 new cases of childhood ALL. An organized effort between multiple sectors is needed to improve the registries of childhood ALL in Indonesia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35696384</pmid><doi>10.1371/journal.pone.0269706</doi><tpages>e0269706</tpages><orcidid>https://orcid.org/0000-0003-2437-6478</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Biology and Life Sciences Cancer Child Child, Preschool Childhood Children Cohort Studies Diagnosis Disease Diseases Distribution Epidemiology Fatalities Female Health care policy Humans Incidence Indonesia - epidemiology Infant Infant, Newborn Leukemia Male Medicine and Health Sciences Meta-analysis Mortality People and Places Physical Sciences Population Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Predictions Quality assessment Registries Research and Analysis Methods Statistical analysis Systematic review |
| title | The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis |
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