Identifying risk factors for prevalent anal human papillomavirus type 16 infection in women living with HIV

Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies. In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genoty...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2022-05, Vol.17 (5), p.e0268521
Hauptverfasser:	Kaufman, Elaina, Williamson, Tyler, Mayrand, Marie-Hélène, Burchell, Ann N, Klein, Marina, Charest, Louise, Rodrigues-Coutlée, Sophie, Coutlée, François, de Pokomandy, Alexandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alphapapillomavirus Anal Canal Anal cancer Anogenital Anus Anus Neoplasms - complications Biology and life sciences Cancer Cancer screening Care and treatment CD4 antigen Cervical cancer Cervix Cohort Studies Colorectal cancer Complications and side effects Computer and Information Sciences Deoxyribonucleic acid DNA Female Genotyping Health risks Hepatitis HIV HIV (Viruses) HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Human papillomavirus Humans Infections Medical research Medicine and Health Sciences Papillomaviridae - genetics Papillomavirus infections Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Prevalence Questionnaires Regression analysis Risk analysis Risk Factors Screening Smoking Statistical analysis Subgroups Vaccines Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue	5
container_start_page	e0268521
container_title	PloS one
container_volume	17
creator	Kaufman, Elaina Williamson, Tyler Mayrand, Marie-Hélène Burchell, Ann N Klein, Marina Charest, Louise Rodrigues-Coutlée, Sophie Coutlée, François de Pokomandy, Alexandra
description	Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies. In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genotyping every 6 months for 2 years, while demographic and clinical data were collected via questionnaires and chart reviews. Here, we present results of baseline data analyzed using multivariable logistic regression. Among 150 women with adequate HPV test results at baseline, HPV 16 DNA was detected anally in 23 (15.3%; 95%CI:10.4-22.1) and cervically in 5 (3.3%; 95%CI:1.4-7.8). In multivariable analysis, current smoking (OR = 6.0; 95%CI: 1.5-23.9), nadir CD4 count ≤ 200 cells/μL (OR = 8.4; 95%CI: 2.0-34.3), prevalent cervical HPV 16 (OR = 14.7; 95%CI: 1.0-222.5) and anogenital herpes in previous 6 months (OR = 9.8, 95%CI: 1.7-56.8) were associated with prevalent anal HPV 16. Knowledge of risk factors can help identify WLHIV at greatest risk of anal HPV 16 infection and, potentially, developing subsequent anal cancer. Identification of the subgroup of these women in whom HPV 16 persists could be an early step in the algorithm of anal cancer screening.
doi_str_mv	10.1371/journal.pone.0268521
format	Article
fullrecord	<record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2686259109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A704328257</galeid><doaj_id>oai_doaj_org_article_471a7c3051f249c8bce14fde4f38456a</doaj_id><sourcerecordid>A704328257</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-8e03345959b0f17769e2c169bd8b45566ad11d7e7e5af28bc25004baaecde1713</originalsourceid><addsrcrecordid>eNqNk11v0zAUhiMEYqPwDxBYQkJw0eKP2IlvkKYJWKVJk_jYreU6duvOiTM76ei_x6HZ1KBdIF_Ysp_zHvs9Pln2GsEFIgX6tPV9aKRbtL7RC4hZSTF6kp0iTvCcYUieHq1PshcxbiGkpGTseXZCKC0LCslpdrOsdNNZs7fNGgQbb4CRqvMhAuMDaIPeSZcAIFMqsOlr2YBWttY5X8udDX0E3b7VADFgG6NVZ32TVuDO17oBzu4G2TvbbcDF8vpl9sxIF_WrcZ5lv75--Xl-Mb-8-rY8P7ucK8ZxNy81JCSnnPIVNKgoGNdYIcZXVbnKKWVMVghVhS40lQaXK4UphPlKSq0qjQpEZtnbg27rfBSjT1EkiximHEGeiOWBqLzcijbYWoa98NKKvxs-rIUMnVVOi7xAslAEUmRwzlVKp1FuKp0bUuaUyaT1eczWr2pdqeRWkG4iOj1p7Eas_U5whDhNxZllH0aB4G97HTtR26i0c7LRvh_uzRiHJaN5Qt_9gz7-upFap9qJVBef8qpBVJwVMCe4xLRI1OIRKo1K11alT2Vs2p8EfJwEJKbTv7u17GMUyx_f_5-9up6y74_YjZau20Tv-uEvxSmYH0AVfIxBmweTERRDT9y7IYaeEGNPpLA3xwV6CLpvAvIH3fEHBQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2686259109</pqid></control><display><type>article</type><title>Identifying risk factors for prevalent anal human papillomavirus type 16 infection in women living with HIV</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Kaufman, Elaina ; Williamson, Tyler ; Mayrand, Marie-Hélène ; Burchell, Ann N ; Klein, Marina ; Charest, Louise ; Rodrigues-Coutlée, Sophie ; Coutlée, François ; de Pokomandy, Alexandra</creator><contributor>Tornesello, Maria Lina</contributor><creatorcontrib>Kaufman, Elaina ; Williamson, Tyler ; Mayrand, Marie-Hélène ; Burchell, Ann N ; Klein, Marina ; Charest, Louise ; Rodrigues-Coutlée, Sophie ; Coutlée, François ; de Pokomandy, Alexandra ; EVVA study group ; on behalf of the EVVA study group ; Tornesello, Maria Lina</creatorcontrib><description>Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies. In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genotyping every 6 months for 2 years, while demographic and clinical data were collected via questionnaires and chart reviews. Here, we present results of baseline data analyzed using multivariable logistic regression. Among 150 women with adequate HPV test results at baseline, HPV 16 DNA was detected anally in 23 (15.3%; 95%CI:10.4-22.1) and cervically in 5 (3.3%; 95%CI:1.4-7.8). In multivariable analysis, current smoking (OR = 6.0; 95%CI: 1.5-23.9), nadir CD4 count ≤ 200 cells/μL (OR = 8.4; 95%CI: 2.0-34.3), prevalent cervical HPV 16 (OR = 14.7; 95%CI: 1.0-222.5) and anogenital herpes in previous 6 months (OR = 9.8, 95%CI: 1.7-56.8) were associated with prevalent anal HPV 16. Knowledge of risk factors can help identify WLHIV at greatest risk of anal HPV 16 infection and, potentially, developing subsequent anal cancer. Identification of the subgroup of these women in whom HPV 16 persists could be an early step in the algorithm of anal cancer screening.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0268521</identifier><identifier>PMID: 35587503</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Algorithms ; Alphapapillomavirus ; Anal Canal ; Anal cancer ; Anogenital ; Anus ; Anus Neoplasms - complications ; Biology and life sciences ; Cancer ; Cancer screening ; Care and treatment ; CD4 antigen ; Cervical cancer ; Cervix ; Cohort Studies ; Colorectal cancer ; Complications and side effects ; Computer and Information Sciences ; Deoxyribonucleic acid ; DNA ; Female ; Genotyping ; Health risks ; Hepatitis ; HIV ; HIV (Viruses) ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Human papillomavirus ; Humans ; Infections ; Medical research ; Medicine and Health Sciences ; Papillomaviridae - genetics ; Papillomavirus infections ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Prevalence ; Questionnaires ; Regression analysis ; Risk analysis ; Risk Factors ; Screening ; Smoking ; Statistical analysis ; Subgroups ; Vaccines ; Womens health</subject><ispartof>PloS one, 2022-05, Vol.17 (5), p.e0268521</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Kaufman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Kaufman et al 2022 Kaufman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8e03345959b0f17769e2c169bd8b45566ad11d7e7e5af28bc25004baaecde1713</citedby><cites>FETCH-LOGICAL-c692t-8e03345959b0f17769e2c169bd8b45566ad11d7e7e5af28bc25004baaecde1713</cites><orcidid>0000-0001-6809-1357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119520/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119520/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35587503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tornesello, Maria Lina</contributor><creatorcontrib>Kaufman, Elaina</creatorcontrib><creatorcontrib>Williamson, Tyler</creatorcontrib><creatorcontrib>Mayrand, Marie-Hélène</creatorcontrib><creatorcontrib>Burchell, Ann N</creatorcontrib><creatorcontrib>Klein, Marina</creatorcontrib><creatorcontrib>Charest, Louise</creatorcontrib><creatorcontrib>Rodrigues-Coutlée, Sophie</creatorcontrib><creatorcontrib>Coutlée, François</creatorcontrib><creatorcontrib>de Pokomandy, Alexandra</creatorcontrib><creatorcontrib>EVVA study group</creatorcontrib><creatorcontrib>on behalf of the EVVA study group</creatorcontrib><title>Identifying risk factors for prevalent anal human papillomavirus type 16 infection in women living with HIV</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies. In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genotyping every 6 months for 2 years, while demographic and clinical data were collected via questionnaires and chart reviews. Here, we present results of baseline data analyzed using multivariable logistic regression. Among 150 women with adequate HPV test results at baseline, HPV 16 DNA was detected anally in 23 (15.3%; 95%CI:10.4-22.1) and cervically in 5 (3.3%; 95%CI:1.4-7.8). In multivariable analysis, current smoking (OR = 6.0; 95%CI: 1.5-23.9), nadir CD4 count ≤ 200 cells/μL (OR = 8.4; 95%CI: 2.0-34.3), prevalent cervical HPV 16 (OR = 14.7; 95%CI: 1.0-222.5) and anogenital herpes in previous 6 months (OR = 9.8, 95%CI: 1.7-56.8) were associated with prevalent anal HPV 16. Knowledge of risk factors can help identify WLHIV at greatest risk of anal HPV 16 infection and, potentially, developing subsequent anal cancer. Identification of the subgroup of these women in whom HPV 16 persists could be an early step in the algorithm of anal cancer screening.</description><subject>Algorithms</subject><subject>Alphapapillomavirus</subject><subject>Anal Canal</subject><subject>Anal cancer</subject><subject>Anogenital</subject><subject>Anus</subject><subject>Anus Neoplasms - complications</subject><subject>Biology and life sciences</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Care and treatment</subject><subject>CD4 antigen</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Cohort Studies</subject><subject>Colorectal cancer</subject><subject>Complications and side effects</subject><subject>Computer and Information Sciences</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Genotyping</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Human immunodeficiency virus</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus infections</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Prevalence</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Screening</subject><subject>Smoking</subject><subject>Statistical analysis</subject><subject>Subgroups</subject><subject>Vaccines</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYqPwDxBYQkJw0eKP2IlvkKYJWKVJk_jYreU6duvOiTM76ei_x6HZ1KBdIF_Ysp_zHvs9Pln2GsEFIgX6tPV9aKRbtL7RC4hZSTF6kp0iTvCcYUieHq1PshcxbiGkpGTseXZCKC0LCslpdrOsdNNZs7fNGgQbb4CRqvMhAuMDaIPeSZcAIFMqsOlr2YBWttY5X8udDX0E3b7VADFgG6NVZ32TVuDO17oBzu4G2TvbbcDF8vpl9sxIF_WrcZ5lv75--Xl-Mb-8-rY8P7ucK8ZxNy81JCSnnPIVNKgoGNdYIcZXVbnKKWVMVghVhS40lQaXK4UphPlKSq0qjQpEZtnbg27rfBSjT1EkiximHEGeiOWBqLzcijbYWoa98NKKvxs-rIUMnVVOi7xAslAEUmRwzlVKp1FuKp0bUuaUyaT1eczWr2pdqeRWkG4iOj1p7Eas_U5whDhNxZllH0aB4G97HTtR26i0c7LRvh_uzRiHJaN5Qt_9gz7-upFap9qJVBef8qpBVJwVMCe4xLRI1OIRKo1K11alT2Vs2p8EfJwEJKbTv7u17GMUyx_f_5-9up6y74_YjZau20Tv-uEvxSmYH0AVfIxBmweTERRDT9y7IYaeEGNPpLA3xwV6CLpvAvIH3fEHBQ</recordid><startdate>20220519</startdate><enddate>20220519</enddate><creator>Kaufman, Elaina</creator><creator>Williamson, Tyler</creator><creator>Mayrand, Marie-Hélène</creator><creator>Burchell, Ann N</creator><creator>Klein, Marina</creator><creator>Charest, Louise</creator><creator>Rodrigues-Coutlée, Sophie</creator><creator>Coutlée, François</creator><creator>de Pokomandy, Alexandra</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6809-1357</orcidid></search><sort><creationdate>20220519</creationdate><title>Identifying risk factors for prevalent anal human papillomavirus type 16 infection in women living with HIV</title><author>Kaufman, Elaina ; Williamson, Tyler ; Mayrand, Marie-Hélène ; Burchell, Ann N ; Klein, Marina ; Charest, Louise ; Rodrigues-Coutlée, Sophie ; Coutlée, François ; de Pokomandy, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8e03345959b0f17769e2c169bd8b45566ad11d7e7e5af28bc25004baaecde1713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Algorithms</topic><topic>Alphapapillomavirus</topic><topic>Anal Canal</topic><topic>Anal cancer</topic><topic>Anogenital</topic><topic>Anus</topic><topic>Anus Neoplasms - complications</topic><topic>Biology and life sciences</topic><topic>Cancer</topic><topic>Cancer screening</topic><topic>Care and treatment</topic><topic>CD4 antigen</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Cohort Studies</topic><topic>Colorectal cancer</topic><topic>Complications and side effects</topic><topic>Computer and Information Sciences</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Female</topic><topic>Genotyping</topic><topic>Health risks</topic><topic>Hepatitis</topic><topic>HIV</topic><topic>HIV (Viruses)</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Human immunodeficiency virus</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Infections</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus infections</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Prevalence</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Screening</topic><topic>Smoking</topic><topic>Statistical analysis</topic><topic>Subgroups</topic><topic>Vaccines</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaufman, Elaina</creatorcontrib><creatorcontrib>Williamson, Tyler</creatorcontrib><creatorcontrib>Mayrand, Marie-Hélène</creatorcontrib><creatorcontrib>Burchell, Ann N</creatorcontrib><creatorcontrib>Klein, Marina</creatorcontrib><creatorcontrib>Charest, Louise</creatorcontrib><creatorcontrib>Rodrigues-Coutlée, Sophie</creatorcontrib><creatorcontrib>Coutlée, François</creatorcontrib><creatorcontrib>de Pokomandy, Alexandra</creatorcontrib><creatorcontrib>EVVA study group</creatorcontrib><creatorcontrib>on behalf of the EVVA study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaufman, Elaina</au><au>Williamson, Tyler</au><au>Mayrand, Marie-Hélène</au><au>Burchell, Ann N</au><au>Klein, Marina</au><au>Charest, Louise</au><au>Rodrigues-Coutlée, Sophie</au><au>Coutlée, François</au><au>de Pokomandy, Alexandra</au><au>Tornesello, Maria Lina</au><aucorp>EVVA study group</aucorp><aucorp>on behalf of the EVVA study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identifying risk factors for prevalent anal human papillomavirus type 16 infection in women living with HIV</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-05-19</date><risdate>2022</risdate><volume>17</volume><issue>5</issue><spage>e0268521</spage><pages>e0268521-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Women living with HIV (WLHIV) have a high risk of anal cancer. Identifying risk factors for anal HPV 16 infection, the most significant risk factor for anal cancer, is essential for prevention and screening strategies. In the EVVA Cohort study, 151 WLHIV had cervical and anal HPV testing with genotyping every 6 months for 2 years, while demographic and clinical data were collected via questionnaires and chart reviews. Here, we present results of baseline data analyzed using multivariable logistic regression. Among 150 women with adequate HPV test results at baseline, HPV 16 DNA was detected anally in 23 (15.3%; 95%CI:10.4-22.1) and cervically in 5 (3.3%; 95%CI:1.4-7.8). In multivariable analysis, current smoking (OR = 6.0; 95%CI: 1.5-23.9), nadir CD4 count ≤ 200 cells/μL (OR = 8.4; 95%CI: 2.0-34.3), prevalent cervical HPV 16 (OR = 14.7; 95%CI: 1.0-222.5) and anogenital herpes in previous 6 months (OR = 9.8, 95%CI: 1.7-56.8) were associated with prevalent anal HPV 16. Knowledge of risk factors can help identify WLHIV at greatest risk of anal HPV 16 infection and, potentially, developing subsequent anal cancer. Identification of the subgroup of these women in whom HPV 16 persists could be an early step in the algorithm of anal cancer screening.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35587503</pmid><doi>10.1371/journal.pone.0268521</doi><tpages>e0268521</tpages><orcidid>https://orcid.org/0000-0001-6809-1357</orcidid><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1932-6203
ispartof	PloS one, 2022-05, Vol.17 (5), p.e0268521
issn	1932-6203 1932-6203
language	eng
recordid	cdi_plos_journals_2686259109
source	MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects	Algorithms Alphapapillomavirus Anal Canal Anal cancer Anogenital Anus Anus Neoplasms - complications Biology and life sciences Cancer Cancer screening Care and treatment CD4 antigen Cervical cancer Cervix Cohort Studies Colorectal cancer Complications and side effects Computer and Information Sciences Deoxyribonucleic acid DNA Female Genotyping Health risks Hepatitis HIV HIV (Viruses) HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Human papillomavirus Humans Infections Medical research Medicine and Health Sciences Papillomaviridae - genetics Papillomavirus infections Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Prevalence Questionnaires Regression analysis Risk analysis Risk Factors Screening Smoking Statistical analysis Subgroups Vaccines Womens health
title	Identifying risk factors for prevalent anal human papillomavirus type 16 infection in women living with HIV
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T09%3A14%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identifying%20risk%20factors%20for%20prevalent%20anal%20human%20papillomavirus%20type%2016%20infection%20in%20women%20living%20with%20HIV&rft.jtitle=PloS%20one&rft.au=Kaufman,%20Elaina&rft.aucorp=EVVA%20study%20group&rft.date=2022-05-19&rft.volume=17&rft.issue=5&rft.spage=e0268521&rft.pages=e0268521-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0268521&rft_dat=%3Cgale_plos_%3EA704328257%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2686259109&rft_id=info:pmid/35587503&rft_galeid=A704328257&rft_doaj_id=oai_doaj_org_article_471a7c3051f249c8bce14fde4f38456a&rfr_iscdi=true