Long-term oncological outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study
Previous studies have shown that the anesthetic technique may influence long-term outcomes after cancer surgery. However, the association between the anesthetic technique and long-term oncological outcomes after oral cancer surgery remains unclear. Therefore, we conducted this study to address this...
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| description | Previous studies have shown that the anesthetic technique may influence long-term outcomes after cancer surgery. However, the association between the anesthetic technique and long-term oncological outcomes after oral cancer surgery remains unclear. Therefore, we conducted this study to address this gap.
We reviewed the electronic medical records of patients who underwent elective oral cancer surgery between January 2014 and December 2015. The patients were grouped based on the anesthesia maintenance: either propofol or sevoflurane. Propensity score matching in a 1:1 ratio was performed to deal with the potential confounding effects of baseline characteristics. Univariate and multivariate Cox regression analyses were performed to compare hazard ratios (HRs) and identify the risk factors for death and recurrence. Survival analysis was performed using the Kaplan-Meier method, and survival curves were constructed from the date of surgery to death.
In total, 1347 patients were eligible for analysis, with 343 and 1004 patients in the propofol and sevoflurane groups, respectively. After propensity score matching, 302 patients remained in each group. Kaplan-Meier survival curves demonstrated the 5-year overall and recurrence-free survival rates of 59.3% and 56.0% and 62.7% and 56.5% in the propofol and sevoflurane groups, respectively. There was no significant difference in overall survival or recurrence-free survival between the groups. The multivariate Cox analysis verified this conclusion with HRs of 1.10 and 1.11 for overall survival and recurrence-free survival, respectively, in the sevoflurane group. Older age, advanced tumor-node-metastasis (TNM) stage, and American Society of Anesthesiologists class III were associated with poor overall survival. Patients with advanced TNM stage and poorly differentiated squamous cell carcinoma had a higher recurrence risk than their counterparts.
The overall and recurrence-free survival rates were similar between propofol-based intravenous anesthesia and sevoflurane volatile anesthesia in patients who underwent oral cancer surgery. |
| doi_str_mv | 10.1371/journal.pone.0268473 |
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We reviewed the electronic medical records of patients who underwent elective oral cancer surgery between January 2014 and December 2015. The patients were grouped based on the anesthesia maintenance: either propofol or sevoflurane. Propensity score matching in a 1:1 ratio was performed to deal with the potential confounding effects of baseline characteristics. Univariate and multivariate Cox regression analyses were performed to compare hazard ratios (HRs) and identify the risk factors for death and recurrence. Survival analysis was performed using the Kaplan-Meier method, and survival curves were constructed from the date of surgery to death.
In total, 1347 patients were eligible for analysis, with 343 and 1004 patients in the propofol and sevoflurane groups, respectively. After propensity score matching, 302 patients remained in each group. Kaplan-Meier survival curves demonstrated the 5-year overall and recurrence-free survival rates of 59.3% and 56.0% and 62.7% and 56.5% in the propofol and sevoflurane groups, respectively. There was no significant difference in overall survival or recurrence-free survival between the groups. The multivariate Cox analysis verified this conclusion with HRs of 1.10 and 1.11 for overall survival and recurrence-free survival, respectively, in the sevoflurane group. Older age, advanced tumor-node-metastasis (TNM) stage, and American Society of Anesthesiologists class III were associated with poor overall survival. Patients with advanced TNM stage and poorly differentiated squamous cell carcinoma had a higher recurrence risk than their counterparts.
The overall and recurrence-free survival rates were similar between propofol-based intravenous anesthesia and sevoflurane volatile anesthesia in patients who underwent oral cancer surgery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0268473</identifier><identifier>PMID: 35559987</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Alcoholism ; Anesthesia ; Breast cancer ; Cancer ; Cancer surgery ; Cancer therapies ; Care and treatment ; Cell differentiation ; Chemotherapy ; Cohort analysis ; Comorbidity ; Comparative analysis ; Dosage and administration ; Electronic health records ; Electronic medical records ; Gastrointestinal cancer ; Hospitals ; Inhalation ; Intravenous administration ; Intubation ; Matching ; Medical personnel ; Medical prognosis ; Medical records ; Medicine and Health Sciences ; Metastases ; Metastasis ; Mortality ; Mouth cancer ; Multivariate analysis ; Oral cancer ; Patient outcomes ; Patients ; Propofol ; Radiation therapy ; Regression analysis ; Respiration ; Risk analysis ; Risk factors ; Sevoflurane ; Squamous cell carcinoma ; Surgery ; Surgical outcomes ; Survival ; Tumors</subject><ispartof>PloS one, 2022-05, Vol.17 (5), p.e0268473-e0268473</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Miao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Miao et al 2022 Miao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2e8f6aed58a62810e2d413d7d30f058a2fb3e0b3c328b8cd9e5e5bddfd3868973</citedby><cites>FETCH-LOGICAL-c692t-2e8f6aed58a62810e2d413d7d30f058a2fb3e0b3c328b8cd9e5e5bddfd3868973</cites><orcidid>0000-0001-9821-7862</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106182/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106182/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35559987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Danan, Deepa</contributor><creatorcontrib>Miao, Lingju</creatorcontrib><creatorcontrib>Lv, Xiang</creatorcontrib><creatorcontrib>Huang, Can</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Jiang, Hong</creatorcontrib><title>Long-term oncological outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Previous studies have shown that the anesthetic technique may influence long-term outcomes after cancer surgery. However, the association between the anesthetic technique and long-term oncological outcomes after oral cancer surgery remains unclear. Therefore, we conducted this study to address this gap.
We reviewed the electronic medical records of patients who underwent elective oral cancer surgery between January 2014 and December 2015. The patients were grouped based on the anesthesia maintenance: either propofol or sevoflurane. Propensity score matching in a 1:1 ratio was performed to deal with the potential confounding effects of baseline characteristics. Univariate and multivariate Cox regression analyses were performed to compare hazard ratios (HRs) and identify the risk factors for death and recurrence. Survival analysis was performed using the Kaplan-Meier method, and survival curves were constructed from the date of surgery to death.
In total, 1347 patients were eligible for analysis, with 343 and 1004 patients in the propofol and sevoflurane groups, respectively. After propensity score matching, 302 patients remained in each group. Kaplan-Meier survival curves demonstrated the 5-year overall and recurrence-free survival rates of 59.3% and 56.0% and 62.7% and 56.5% in the propofol and sevoflurane groups, respectively. There was no significant difference in overall survival or recurrence-free survival between the groups. The multivariate Cox analysis verified this conclusion with HRs of 1.10 and 1.11 for overall survival and recurrence-free survival, respectively, in the sevoflurane group. Older age, advanced tumor-node-metastasis (TNM) stage, and American Society of Anesthesiologists class III were associated with poor overall survival. Patients with advanced TNM stage and poorly differentiated squamous cell carcinoma had a higher recurrence risk than their counterparts.
The overall and recurrence-free survival rates were similar between propofol-based intravenous anesthesia and sevoflurane volatile anesthesia in patients who underwent oral cancer surgery.</description><subject>Age</subject><subject>Alcoholism</subject><subject>Anesthesia</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer surgery</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell differentiation</subject><subject>Chemotherapy</subject><subject>Cohort analysis</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Dosage and administration</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Gastrointestinal cancer</subject><subject>Hospitals</subject><subject>Inhalation</subject><subject>Intravenous administration</subject><subject>Intubation</subject><subject>Matching</subject><subject>Medical 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oncological outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study</title><author>Miao, Lingju ; Lv, Xiang ; Huang, Can ; Li, Ping ; Sun, Yu ; Jiang, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2e8f6aed58a62810e2d413d7d30f058a2fb3e0b3c328b8cd9e5e5bddfd3868973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Alcoholism</topic><topic>Anesthesia</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer surgery</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cell differentiation</topic><topic>Chemotherapy</topic><topic>Cohort analysis</topic><topic>Comorbidity</topic><topic>Comparative analysis</topic><topic>Dosage and administration</topic><topic>Electronic health records</topic><topic>Electronic 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outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-05-13</date><risdate>2022</risdate><volume>17</volume><issue>5</issue><spage>e0268473</spage><epage>e0268473</epage><pages>e0268473-e0268473</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Previous studies have shown that the anesthetic technique may influence long-term outcomes after cancer surgery. However, the association between the anesthetic technique and long-term oncological outcomes after oral cancer surgery remains unclear. Therefore, we conducted this study to address this gap.
We reviewed the electronic medical records of patients who underwent elective oral cancer surgery between January 2014 and December 2015. The patients were grouped based on the anesthesia maintenance: either propofol or sevoflurane. Propensity score matching in a 1:1 ratio was performed to deal with the potential confounding effects of baseline characteristics. Univariate and multivariate Cox regression analyses were performed to compare hazard ratios (HRs) and identify the risk factors for death and recurrence. Survival analysis was performed using the Kaplan-Meier method, and survival curves were constructed from the date of surgery to death.
In total, 1347 patients were eligible for analysis, with 343 and 1004 patients in the propofol and sevoflurane groups, respectively. After propensity score matching, 302 patients remained in each group. Kaplan-Meier survival curves demonstrated the 5-year overall and recurrence-free survival rates of 59.3% and 56.0% and 62.7% and 56.5% in the propofol and sevoflurane groups, respectively. There was no significant difference in overall survival or recurrence-free survival between the groups. The multivariate Cox analysis verified this conclusion with HRs of 1.10 and 1.11 for overall survival and recurrence-free survival, respectively, in the sevoflurane group. Older age, advanced tumor-node-metastasis (TNM) stage, and American Society of Anesthesiologists class III were associated with poor overall survival. Patients with advanced TNM stage and poorly differentiated squamous cell carcinoma had a higher recurrence risk than their counterparts.
The overall and recurrence-free survival rates were similar between propofol-based intravenous anesthesia and sevoflurane volatile anesthesia in patients who underwent oral cancer surgery.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35559987</pmid><doi>10.1371/journal.pone.0268473</doi><tpages>e0268473</tpages><orcidid>https://orcid.org/0000-0001-9821-7862</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Alcoholism Anesthesia Breast cancer Cancer Cancer surgery Cancer therapies Care and treatment Cell differentiation Chemotherapy Cohort analysis Comorbidity Comparative analysis Dosage and administration Electronic health records Electronic medical records Gastrointestinal cancer Hospitals Inhalation Intravenous administration Intubation Matching Medical personnel Medical prognosis Medical records Medicine and Health Sciences Metastases Metastasis Mortality Mouth cancer Multivariate analysis Oral cancer Patient outcomes Patients Propofol Radiation therapy Regression analysis Respiration Risk analysis Risk factors Sevoflurane Squamous cell carcinoma Surgery Surgical outcomes Survival Tumors |
| title | Long-term oncological outcomes after oral cancer surgery using propofol-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia: A retrospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T01%3A28%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20oncological%20outcomes%20after%20oral%20cancer%20surgery%20using%20propofol-based%20total%20intravenous%20anesthesia%20versus%20sevoflurane-based%20inhalation%20anesthesia:%20A%20retrospective%20cohort%20study&rft.jtitle=PloS%20one&rft.au=Miao,%20Lingju&rft.date=2022-05-13&rft.volume=17&rft.issue=5&rft.spage=e0268473&rft.epage=e0268473&rft.pages=e0268473-e0268473&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0268473&rft_dat=%3Cgale_plos_%3EA703599789%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2686248689&rft_id=info:pmid/35559987&rft_galeid=A703599789&rft_doaj_id=oai_doaj_org_article_24df5b94bb00461f94de3581c2a6f292&rfr_iscdi=true |