Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid
We aimed to determine whether various novel inflammatory, angiogenic, and extracellular matrix-related mediators in amniotic fluid (AF) can independently predict emergency cerclage outcomes in women with acute cervical insufficiency (CI). This was a retrospective cohort study conducted among 50 sing...
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| description | We aimed to determine whether various novel inflammatory, angiogenic, and extracellular matrix-related mediators in amniotic fluid (AF) can independently predict emergency cerclage outcomes in women with acute cervical insufficiency (CI).
This was a retrospective cohort study conducted among 50 singleton pregnant women (18-25 weeks) who underwent emergency cerclage for CI and were subjected to amniocentesis. The AF samples were assayed for endoglin, endostatin, haptoglobin, insulin-like growth factor-binding protein (IGFBP)-3, -4, kallistatin, lumican, macrophage colony-stimulating factor (M-CSF), pentraxin 3, p-selectin, receptor for advanced glycation end products (RAGE), resistin, transforming growth factor beta-induced (TGFBI), and vitamin D-binding protein (VDBP) levels. Interleukin (IL)-6 levels in the AF were also measured for comparison with potential biomarkers assessed in this study. The primary endpoint was spontaneous preterm delivery (SPTD) at |
| doi_str_mv | 10.1371/journal.pone.0268291 |
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This was a retrospective cohort study conducted among 50 singleton pregnant women (18-25 weeks) who underwent emergency cerclage for CI and were subjected to amniocentesis. The AF samples were assayed for endoglin, endostatin, haptoglobin, insulin-like growth factor-binding protein (IGFBP)-3, -4, kallistatin, lumican, macrophage colony-stimulating factor (M-CSF), pentraxin 3, p-selectin, receptor for advanced glycation end products (RAGE), resistin, transforming growth factor beta-induced (TGFBI), and vitamin D-binding protein (VDBP) levels. Interleukin (IL)-6 levels in the AF were also measured for comparison with potential biomarkers assessed in this study. The primary endpoint was spontaneous preterm delivery (SPTD) at <34 weeks following emergency cerclage.
The AF levels of pentraxin 3, RAGE, and resistin were significantly higher in women who had SPTD at <34 weeks after cerclage placement (pentraxin-3: P = 0.003; RAGE: P = 0.041; and resistin; P = 0.002). In multivariate analysis, elevated AF levels of pentraxin 3 (P = 0.007) and resistin (P = 0.006), but not those of RAGE (P = 0.069), were independently associated with the occurrence of SPTD at <34 weeks after cerclage, following adjustment for baseline clinical variables (e.g., cervical dilation). The area under the curve (AUC) values of AF pentraxin 3, RAGE, and resistin for the prediction of SPTD at <34 weeks were 0.749, 0.669, and 0.770, respectively, which were similar to those of AF IL-6. However, in univariate analyses, no differences in the AF levels of endoglin, endostatin, haptoglobin, IGFBP-3, IGFBP-4, kallistatin, lumican, p-selectin, TGFBI, and VDBP were found to be associated with SPTD at <34 weeks after cerclage placement.
In women with acute CI, the AF levels of pentraxin 3, RAGE, and resistin could be useful novel biomarkers for predicting SPTD following emergency cerclage. However, the clinical utility of these new biomarkers should be validated in larger multicenter studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0268291</identifier><identifier>PMID: 35536791</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Advanced glycosylation end products ; Amniocentesis ; Amniotic fluid ; Angiogenesis ; Antibiotics ; Biology and Life Sciences ; Biomarkers ; Cervical cerclage ; Colony-stimulating factor ; Complications and side effects ; Decision making ; Emergencies ; Endoglin ; Endostatin ; Extracellular matrix ; Fetuses ; Glycosylation ; Growth factors ; Haptoglobin ; Health aspects ; Inflammation ; Insulin ; Insulin-like growth factor-binding protein 3 ; Insulin-like growth factor-binding protein 4 ; Interleukin 6 ; Macrophage colony-stimulating factor ; Medicine and Health Sciences ; Multivariate analysis ; P-selectin ; Pentraxins ; Placement ; Pregnancy ; Pregnancy, Complications of ; Pregnant women ; Premature birth ; Proteins ; Regression analysis ; Risk factors ; Sutures ; Transforming growth factor-b ; Vitamin D ; Vitamin D-binding protein</subject><ispartof>PloS one, 2022-05, Vol.17 (5), p.e0268291-e0268291</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Lee et al 2022 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6433-bb6135d3bcaa5a41bf3e9e3fc7a64bd4e9dfb6674ff184b6f0118c4d6a0d6a723</citedby><cites>FETCH-LOGICAL-c6433-bb6135d3bcaa5a41bf3e9e3fc7a64bd4e9dfb6674ff184b6f0118c4d6a0d6a723</cites><orcidid>0000-0003-3550-9686</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089878/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089878/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35536791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mueller, Martin</contributor><creatorcontrib>Lee, Kyong-No</creatorcontrib><creatorcontrib>Park, Kyo Hoon</creatorcontrib><creatorcontrib>Kim, Yu Mi</creatorcontrib><creatorcontrib>Cho, Iseop</creatorcontrib><creatorcontrib>Kim, Tae Eun</creatorcontrib><title>Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We aimed to determine whether various novel inflammatory, angiogenic, and extracellular matrix-related mediators in amniotic fluid (AF) can independently predict emergency cerclage outcomes in women with acute cervical insufficiency (CI).
This was a retrospective cohort study conducted among 50 singleton pregnant women (18-25 weeks) who underwent emergency cerclage for CI and were subjected to amniocentesis. The AF samples were assayed for endoglin, endostatin, haptoglobin, insulin-like growth factor-binding protein (IGFBP)-3, -4, kallistatin, lumican, macrophage colony-stimulating factor (M-CSF), pentraxin 3, p-selectin, receptor for advanced glycation end products (RAGE), resistin, transforming growth factor beta-induced (TGFBI), and vitamin D-binding protein (VDBP) levels. Interleukin (IL)-6 levels in the AF were also measured for comparison with potential biomarkers assessed in this study. The primary endpoint was spontaneous preterm delivery (SPTD) at <34 weeks following emergency cerclage.
The AF levels of pentraxin 3, RAGE, and resistin were significantly higher in women who had SPTD at <34 weeks after cerclage placement (pentraxin-3: P = 0.003; RAGE: P = 0.041; and resistin; P = 0.002). In multivariate analysis, elevated AF levels of pentraxin 3 (P = 0.007) and resistin (P = 0.006), but not those of RAGE (P = 0.069), were independently associated with the occurrence of SPTD at <34 weeks after cerclage, following adjustment for baseline clinical variables (e.g., cervical dilation). The area under the curve (AUC) values of AF pentraxin 3, RAGE, and resistin for the prediction of SPTD at <34 weeks were 0.749, 0.669, and 0.770, respectively, which were similar to those of AF IL-6. However, in univariate analyses, no differences in the AF levels of endoglin, endostatin, haptoglobin, IGFBP-3, IGFBP-4, kallistatin, lumican, p-selectin, TGFBI, and VDBP were found to be associated with SPTD at <34 weeks after cerclage placement.
In women with acute CI, the AF levels of pentraxin 3, RAGE, and resistin could be useful novel biomarkers for predicting SPTD following emergency cerclage. However, the clinical utility of these new biomarkers should be validated in larger multicenter studies.</description><subject>Advanced glycosylation end products</subject><subject>Amniocentesis</subject><subject>Amniotic fluid</subject><subject>Angiogenesis</subject><subject>Antibiotics</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cervical cerclage</subject><subject>Colony-stimulating factor</subject><subject>Complications and side effects</subject><subject>Decision making</subject><subject>Emergencies</subject><subject>Endoglin</subject><subject>Endostatin</subject><subject>Extracellular matrix</subject><subject>Fetuses</subject><subject>Glycosylation</subject><subject>Growth factors</subject><subject>Haptoglobin</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin-like growth factor-binding protein 3</subject><subject>Insulin-like growth factor-binding protein 4</subject><subject>Interleukin 6</subject><subject>Macrophage colony-stimulating factor</subject><subject>Medicine and Health Sciences</subject><subject>Multivariate analysis</subject><subject>P-selectin</subject><subject>Pentraxins</subject><subject>Placement</subject><subject>Pregnancy</subject><subject>Pregnancy, Complications of</subject><subject>Pregnant women</subject><subject>Premature birth</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Sutures</subject><subject>Transforming growth factor-b</subject><subject>Vitamin D</subject><subject>Vitamin D-binding protein</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21r1TAUx4sobk6_gWhAEAXvNWnatPGFMIYPg8FEp2_DaXrSm5E216Sd28fyG5p678au7IWUtoeT3_nn5OScLHvK6JLxir0991MYwC3XfsAlzUWdS3Yv22eS5wuRU37_lr2XPYrxnNKS10I8zPZ4WXJRSbaf_f4SsLV6tH4g3hDsMXQ46CuiMWgHHRI_jdr3GIkdyK9kpK8dV_P6hdXgkjtOxlht57B35GyFJHiHs5odjIO-h9GHqzcEhs76JG71bLcEL8cAGp2bHASSqGAvFwEdjNiSdfAjJul5V-gH60eriXGTbR9nDwy4iE-2_4Ps-8cPZ0efFyenn46PDk8WWhScL5pGMF62vNEAJRSsMRwlcqMrEEXTFihb0whRFcawumiEoYzVumgF0PRWOT_Inm90185Hta12VKnQIi9KQWkijjdE6-FcrYPtIVwpD1b9dfjQKQgpb4eKSsqpNiaXvEq5SAkyb4ocGsOEKTkkrffb3aamx1bjkIrjdkR3Vwa7Up2_UJLWsq7qJPBqKxD8zwnjqHob5-rCgH6a8xZMlvkm7xf_oHefbkt1kA6QrtLP1zWLqsOKcsbrkhaJWt5BpafF3urUmsYm_07A652AxIypEzqYYlTH377-P3v6Y5d9eYtdIbhxFb2b5s6Ou2CxAXXwMQY0N0VmVM2TdV0NNU-W2k5WCnt2-4Jugq5Hif8BO8sipw</recordid><startdate>20220510</startdate><enddate>20220510</enddate><creator>Lee, 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of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid</title><author>Lee, Kyong-No ; Park, Kyo Hoon ; Kim, Yu Mi ; Cho, Iseop ; Kim, Tae Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6433-bb6135d3bcaa5a41bf3e9e3fc7a64bd4e9dfb6674ff184b6f0118c4d6a0d6a723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Advanced glycosylation end products</topic><topic>Amniocentesis</topic><topic>Amniotic fluid</topic><topic>Angiogenesis</topic><topic>Antibiotics</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Cervical cerclage</topic><topic>Colony-stimulating factor</topic><topic>Complications and side effects</topic><topic>Decision making</topic><topic>Emergencies</topic><topic>Endoglin</topic><topic>Endostatin</topic><topic>Extracellular matrix</topic><topic>Fetuses</topic><topic>Glycosylation</topic><topic>Growth factors</topic><topic>Haptoglobin</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin-like growth factor-binding protein 3</topic><topic>Insulin-like growth factor-binding protein 4</topic><topic>Interleukin 6</topic><topic>Macrophage colony-stimulating factor</topic><topic>Medicine and Health Sciences</topic><topic>Multivariate analysis</topic><topic>P-selectin</topic><topic>Pentraxins</topic><topic>Placement</topic><topic>Pregnancy</topic><topic>Pregnancy, Complications of</topic><topic>Pregnant women</topic><topic>Premature birth</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Sutures</topic><topic>Transforming growth factor-b</topic><topic>Vitamin D</topic><topic>Vitamin D-binding protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kyong-No</creatorcontrib><creatorcontrib>Park, Kyo Hoon</creatorcontrib><creatorcontrib>Kim, Yu Mi</creatorcontrib><creatorcontrib>Cho, Iseop</creatorcontrib><creatorcontrib>Kim, Tae Eun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural 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insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-05-10</date><risdate>2022</risdate><volume>17</volume><issue>5</issue><spage>e0268291</spage><epage>e0268291</epage><pages>e0268291-e0268291</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We aimed to determine whether various novel inflammatory, angiogenic, and extracellular matrix-related mediators in amniotic fluid (AF) can independently predict emergency cerclage outcomes in women with acute cervical insufficiency (CI).
This was a retrospective cohort study conducted among 50 singleton pregnant women (18-25 weeks) who underwent emergency cerclage for CI and were subjected to amniocentesis. The AF samples were assayed for endoglin, endostatin, haptoglobin, insulin-like growth factor-binding protein (IGFBP)-3, -4, kallistatin, lumican, macrophage colony-stimulating factor (M-CSF), pentraxin 3, p-selectin, receptor for advanced glycation end products (RAGE), resistin, transforming growth factor beta-induced (TGFBI), and vitamin D-binding protein (VDBP) levels. Interleukin (IL)-6 levels in the AF were also measured for comparison with potential biomarkers assessed in this study. The primary endpoint was spontaneous preterm delivery (SPTD) at <34 weeks following emergency cerclage.
The AF levels of pentraxin 3, RAGE, and resistin were significantly higher in women who had SPTD at <34 weeks after cerclage placement (pentraxin-3: P = 0.003; RAGE: P = 0.041; and resistin; P = 0.002). In multivariate analysis, elevated AF levels of pentraxin 3 (P = 0.007) and resistin (P = 0.006), but not those of RAGE (P = 0.069), were independently associated with the occurrence of SPTD at <34 weeks after cerclage, following adjustment for baseline clinical variables (e.g., cervical dilation). The area under the curve (AUC) values of AF pentraxin 3, RAGE, and resistin for the prediction of SPTD at <34 weeks were 0.749, 0.669, and 0.770, respectively, which were similar to those of AF IL-6. However, in univariate analyses, no differences in the AF levels of endoglin, endostatin, haptoglobin, IGFBP-3, IGFBP-4, kallistatin, lumican, p-selectin, TGFBI, and VDBP were found to be associated with SPTD at <34 weeks after cerclage placement.
In women with acute CI, the AF levels of pentraxin 3, RAGE, and resistin could be useful novel biomarkers for predicting SPTD following emergency cerclage. However, the clinical utility of these new biomarkers should be validated in larger multicenter studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35536791</pmid><doi>10.1371/journal.pone.0268291</doi><tpages>e0268291</tpages><orcidid>https://orcid.org/0000-0003-3550-9686</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2686245600 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Advanced glycosylation end products Amniocentesis Amniotic fluid Angiogenesis Antibiotics Biology and Life Sciences Biomarkers Cervical cerclage Colony-stimulating factor Complications and side effects Decision making Emergencies Endoglin Endostatin Extracellular matrix Fetuses Glycosylation Growth factors Haptoglobin Health aspects Inflammation Insulin Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Interleukin 6 Macrophage colony-stimulating factor Medicine and Health Sciences Multivariate analysis P-selectin Pentraxins Placement Pregnancy Pregnancy, Complications of Pregnant women Premature birth Proteins Regression analysis Risk factors Sutures Transforming growth factor-b Vitamin D Vitamin D-binding protein |
| title | Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T02%3A49%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prediction%20of%20emergency%20cerclage%20outcomes%20in%20women%20with%20cervical%20insufficiency:%20The%20role%20of%20inflammatory,%20angiogenic,%20and%20extracellular%20matrix-related%20proteins%20in%20amniotic%20fluid&rft.jtitle=PloS%20one&rft.au=Lee,%20Kyong-No&rft.date=2022-05-10&rft.volume=17&rft.issue=5&rft.spage=e0268291&rft.epage=e0268291&rft.pages=e0268291-e0268291&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0268291&rft_dat=%3Cgale_plos_%3EA703138504%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2686245600&rft_id=info:pmid/35536791&rft_galeid=A703138504&rft_doaj_id=oai_doaj_org_article_09030cff293741b99a92b42abf16f53a&rfr_iscdi=true |