Gender effect in survival after out-of-hospital cardiac arrest: A nationwide, population-based, case-control propensity score matched study based Korean national cardiac arrest registry
This study aimed to describe the relationship between sex and survival of patients with out-of-hospital cardiac arrest (OHCA) and further investigate the potential impact of female reproductive hormones on survival outcomes, by stratifying the patients into two age groups. This retrospective, nation...
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| description | This study aimed to describe the relationship between sex and survival of patients with out-of-hospital cardiac arrest (OHCA) and further investigate the potential impact of female reproductive hormones on survival outcomes, by stratifying the patients into two age groups.
This retrospective, national population-based observational, case-control study, included Korean OHCA data from January 1, 2009, to December 31, 2016. We used multiple logistic regression with propensity score-matched data. The primary outcome was survival-to-discharge.
Of the 94,160 patients with OHCA included, 34.2% were women. Before propensity score matching (PSM), the survival-to-discharge rate was 5.2% for females and 9.1% for males, in the entire group (OR 0.556, 95% CI [-0.526-0.588], P |
| doi_str_mv | 10.1371/journal.pone.0258673 |
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This retrospective, national population-based observational, case-control study, included Korean OHCA data from January 1, 2009, to December 31, 2016. We used multiple logistic regression with propensity score-matched data. The primary outcome was survival-to-discharge.
Of the 94,160 patients with OHCA included, 34.2% were women. Before propensity score matching (PSM), the survival-to-discharge rate was 5.2% for females and 9.1% for males, in the entire group (OR 0.556, 95% CI [-0.526-0.588], P<0.001). In the reproductive age group (age 18-44 years), the survival-to-discharge rate was 14% for females and 15.6% for males (OR 0.879, 95% CI [0.765-1.012], P = 0,072) and in the post-menopause age group (age ≥ 55 years), the survival-to-discharge rate was 4.1% for females and 7% for males (OR 0.562, 95% CI [0.524-0.603], P<0.001). After PSM (28,577 patients of each sex), the survival-to-discharge rate was 5.4% for females and 5.4% for males (OR, 1.009 [0.938-1.085], P = 0.810). In the reproductive age group, the survival-to-discharge rate was 14.5% for females and 11.5% for males (OR 1.306, 95% CI [1.079-1.580], P = 0.006) and in the post-menopause age group, the survival-to-discharge rate was 4.2% for females and 4.6% for males (OR 0.904, 95% CI [0.828-0.986], P = 0.022). After adjustment for confounders, women of reproductive age were more likely to survive at hospital discharge. However, there was no statistically significant difference in neurological outcome (OR 1.238, 95% CI [0.979-1.566], P = 0.074).
Females of reproductive age had a better chance of survival when matched for confounding factors. Further studies using sex hormones are needed to improve the survival rate of patients with OHCA.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0258673</identifier><identifier>PMID: 35544548</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Age groups ; Biology and Life Sciences ; Cardiac arrest ; Cardiopulmonary Resuscitation ; Case-Control Studies ; CPR ; Demographic aspects ; Disease control ; Disease prevention ; Emergency Medical Services ; Engineering and Technology ; Estrogens ; Female ; Females ; Gender ; Heart ; Hormones ; Humans ; Male ; Males ; Medicine and Health Sciences ; Menopause ; Middle Aged ; Out-of-Hospital Cardiac Arrest ; Patient outcomes ; Patients ; People and Places ; Physical Sciences ; Population ; Population studies ; Population-based studies ; Post-menopause ; Propensity Score ; Registries ; Republic of Korea - epidemiology ; Research and Analysis Methods ; Retrospective Studies ; Sex hormones ; Sexes ; Statistical analysis ; Survival ; Women ; Womens health ; Young Adult</subject><ispartof>PloS one, 2022-05, Vol.17 (5), p.e0258673-e0258673</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Choi et al 2022 Choi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c673t-d8dac6a73f9cf5d84249a342b08d616d8072a5a8028d6124ca44098e4fa93e1f3</citedby><cites>FETCH-LOGICAL-c673t-d8dac6a73f9cf5d84249a342b08d616d8072a5a8028d6124ca44098e4fa93e1f3</cites><orcidid>0000-0001-8891-3055 ; 0000-0002-2624-0008 ; 0000-0001-9201-5223</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094503/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094503/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35544548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Savastano, Simone</contributor><creatorcontrib>Choi, Han Zo</creatorcontrib><creatorcontrib>Chang, Hansol</creatorcontrib><creatorcontrib>Ko, Seok Hoon</creatorcontrib><creatorcontrib>Kim, Myung Chun</creatorcontrib><title>Gender effect in survival after out-of-hospital cardiac arrest: A nationwide, population-based, case-control propensity score matched study based Korean national cardiac arrest registry</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to describe the relationship between sex and survival of patients with out-of-hospital cardiac arrest (OHCA) and further investigate the potential impact of female reproductive hormones on survival outcomes, by stratifying the patients into two age groups.
This retrospective, national population-based observational, case-control study, included Korean OHCA data from January 1, 2009, to December 31, 2016. We used multiple logistic regression with propensity score-matched data. The primary outcome was survival-to-discharge.
Of the 94,160 patients with OHCA included, 34.2% were women. Before propensity score matching (PSM), the survival-to-discharge rate was 5.2% for females and 9.1% for males, in the entire group (OR 0.556, 95% CI [-0.526-0.588], P<0.001). In the reproductive age group (age 18-44 years), the survival-to-discharge rate was 14% for females and 15.6% for males (OR 0.879, 95% CI [0.765-1.012], P = 0,072) and in the post-menopause age group (age ≥ 55 years), the survival-to-discharge rate was 4.1% for females and 7% for males (OR 0.562, 95% CI [0.524-0.603], P<0.001). After PSM (28,577 patients of each sex), the survival-to-discharge rate was 5.4% for females and 5.4% for males (OR, 1.009 [0.938-1.085], P = 0.810). In the reproductive age group, the survival-to-discharge rate was 14.5% for females and 11.5% for males (OR 1.306, 95% CI [1.079-1.580], P = 0.006) and in the post-menopause age group, the survival-to-discharge rate was 4.2% for females and 4.6% for males (OR 0.904, 95% CI [0.828-0.986], P = 0.022). After adjustment for confounders, women of reproductive age were more likely to survive at hospital discharge. However, there was no statistically significant difference in neurological outcome (OR 1.238, 95% CI [0.979-1.566], P = 0.074).
Females of reproductive age had a better chance of survival when matched for confounding factors. Further studies using sex hormones are needed to improve the survival rate of patients with OHCA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age groups</subject><subject>Biology and Life Sciences</subject><subject>Cardiac arrest</subject><subject>Cardiopulmonary Resuscitation</subject><subject>Case-Control Studies</subject><subject>CPR</subject><subject>Demographic aspects</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Emergency Medical Services</subject><subject>Engineering and Technology</subject><subject>Estrogens</subject><subject>Female</subject><subject>Females</subject><subject>Gender</subject><subject>Heart</subject><subject>Hormones</subject><subject>Humans</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Out-of-Hospital Cardiac Arrest</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Post-menopause</subject><subject>Propensity Score</subject><subject>Registries</subject><subject>Republic of Korea - epidemiology</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Sex hormones</subject><subject>Sexes</subject><subject>Statistical analysis</subject><subject>Survival</subject><subject>Women</subject><subject>Womens health</subject><subject>Young 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effect in survival after out-of-hospital cardiac arrest: A nationwide, population-based, case-control propensity score matched study based Korean national cardiac arrest registry</title><author>Choi, Han Zo ; Chang, Hansol ; Ko, Seok Hoon ; Kim, Myung Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c673t-d8dac6a73f9cf5d84249a342b08d616d8072a5a8028d6124ca44098e4fa93e1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age groups</topic><topic>Biology and Life Sciences</topic><topic>Cardiac arrest</topic><topic>Cardiopulmonary Resuscitation</topic><topic>Case-Control Studies</topic><topic>CPR</topic><topic>Demographic aspects</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Emergency Medical Services</topic><topic>Engineering and 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Han Zo</au><au>Chang, Hansol</au><au>Ko, Seok Hoon</au><au>Kim, Myung Chun</au><au>Savastano, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender effect in survival after out-of-hospital cardiac arrest: A nationwide, population-based, case-control propensity score matched study based Korean national cardiac arrest registry</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-05-11</date><risdate>2022</risdate><volume>17</volume><issue>5</issue><spage>e0258673</spage><epage>e0258673</epage><pages>e0258673-e0258673</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to describe the relationship between sex and survival of patients with out-of-hospital cardiac arrest (OHCA) and further investigate the potential impact of female reproductive hormones on survival outcomes, by stratifying the patients into two age groups.
This retrospective, national population-based observational, case-control study, included Korean OHCA data from January 1, 2009, to December 31, 2016. We used multiple logistic regression with propensity score-matched data. The primary outcome was survival-to-discharge.
Of the 94,160 patients with OHCA included, 34.2% were women. Before propensity score matching (PSM), the survival-to-discharge rate was 5.2% for females and 9.1% for males, in the entire group (OR 0.556, 95% CI [-0.526-0.588], P<0.001). In the reproductive age group (age 18-44 years), the survival-to-discharge rate was 14% for females and 15.6% for males (OR 0.879, 95% CI [0.765-1.012], P = 0,072) and in the post-menopause age group (age ≥ 55 years), the survival-to-discharge rate was 4.1% for females and 7% for males (OR 0.562, 95% CI [0.524-0.603], P<0.001). After PSM (28,577 patients of each sex), the survival-to-discharge rate was 5.4% for females and 5.4% for males (OR, 1.009 [0.938-1.085], P = 0.810). In the reproductive age group, the survival-to-discharge rate was 14.5% for females and 11.5% for males (OR 1.306, 95% CI [1.079-1.580], P = 0.006) and in the post-menopause age group, the survival-to-discharge rate was 4.2% for females and 4.6% for males (OR 0.904, 95% CI [0.828-0.986], P = 0.022). After adjustment for confounders, women of reproductive age were more likely to survive at hospital discharge. However, there was no statistically significant difference in neurological outcome (OR 1.238, 95% CI [0.979-1.566], P = 0.074).
Females of reproductive age had a better chance of survival when matched for confounding factors. Further studies using sex hormones are needed to improve the survival rate of patients with OHCA.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35544548</pmid><doi>10.1371/journal.pone.0258673</doi><tpages>e0258673</tpages><orcidid>https://orcid.org/0000-0001-8891-3055</orcidid><orcidid>https://orcid.org/0000-0002-2624-0008</orcidid><orcidid>https://orcid.org/0000-0001-9201-5223</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2686245567 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age Age groups Biology and Life Sciences Cardiac arrest Cardiopulmonary Resuscitation Case-Control Studies CPR Demographic aspects Disease control Disease prevention Emergency Medical Services Engineering and Technology Estrogens Female Females Gender Heart Hormones Humans Male Males Medicine and Health Sciences Menopause Middle Aged Out-of-Hospital Cardiac Arrest Patient outcomes Patients People and Places Physical Sciences Population Population studies Population-based studies Post-menopause Propensity Score Registries Republic of Korea - epidemiology Research and Analysis Methods Retrospective Studies Sex hormones Sexes Statistical analysis Survival Women Womens health Young Adult |
| title | Gender effect in survival after out-of-hospital cardiac arrest: A nationwide, population-based, case-control propensity score matched study based Korean national cardiac arrest registry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A51%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gender%20effect%20in%20survival%20after%20out-of-hospital%20cardiac%20arrest:%20A%20nationwide,%20population-based,%20case-control%20propensity%20score%20matched%20study%20based%20Korean%20national%20cardiac%20arrest%20registry&rft.jtitle=PloS%20one&rft.au=Choi,%20Han%20Zo&rft.date=2022-05-11&rft.volume=17&rft.issue=5&rft.spage=e0258673&rft.epage=e0258673&rft.pages=e0258673-e0258673&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0258673&rft_dat=%3Cgale_plos_%3EA703272091%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2686245567&rft_id=info:pmid/35544548&rft_galeid=A703272091&rft_doaj_id=oai_doaj_org_article_55d81074ba6245ee83f90a54084b95ae&rfr_iscdi=true |