Targeted mutagenesis in Anaplasma marginale to define virulence and vaccine development against bovine anaplasmosis

Tick-borne Anaplasma species are obligate, intracellular, bacterial pathogens that cause important diseases globally in people, agricultural animals, and dogs. Targeted mutagenesis methods are yet to be developed to define genes essential for these pathogens. In addition, vaccines conferring protect...

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Veröffentlicht in:	PLoS pathogens 2022-05, Vol.18 (5), p.e1010540
Hauptverfasser:	Hove, Paidashe, Madesh, Swetha, Nair, Arathy, Jaworski, Deborah, Liu, Huitao, Ferm, Jonathan, Kleinhenz, Michael D, Highland, Margaret A, Curtis, Andrew K, Coetzee, Johann F, Noh, Susan M, Wang, Ying, Genda, Dominica, Ganta, Roman R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplasma Anaplasma marginale Anaplasma marginale - genetics Anaplasmosis Anaplasmosis - genetics Anaplasmosis - prevention & control Anemia Animals Antigens Arachnids Biology and Life Sciences Cattle Cattle Diseases - microbiology Cell size Dairy cattle Disease Disease control Dogs Enzymes Erythrocytes Gene deletion Gene mutations Genes Genetic aspects Genomes Health aspects Host-parasite relationships Humans Identification and classification In vivo methods and tests Infections Medicine and Health Sciences Microscopy Mutagenesis Mutants Mutation Pathogens Phages Prevention Research and Analysis Methods Site-directed mutagenesis Species Targeted mutagenesis Vaccine Development Vaccines Viral proteins Virulence Virulence (Microbiology)
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