Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β

Skeletal muscle regeneration is essential for maintaining muscle function in injury and muscular disease. Myogenesis plays key roles in forming new myofibers during the process. Here, through bioinformatic screen for the potential regulators of myogenesis from 5 independent microarray datasets, we i...

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Veröffentlicht in:	PLoS biology 2022-04, Vol.20 (4), p.e3001619-e3001619
Hauptverfasser:	Shi, Xiao Chen, Xia, Bo, Zhang, Jian Feng, Zhang, Rui Xin, Zhang, Dan Yang, Liu, Huan, Xie, Bao Cai, Wang, Yong Liang, Wu, Jiang Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Biology and Life Sciences Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell death Cell Differentiation - genetics Datasets Degradation Differentiation DNA microarrays Gene expression Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Glycogens Kinases LEF/TCF protein Lymphocytes T Medical innovations Medicine and Health Sciences Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice Muscle Development - genetics Muscle, Skeletal - metabolism Muscles Muscular diseases Muscular dystrophy Musculoskeletal system Myoblasts Myogenesis Proteins Regeneration Research and Analysis Methods Roles Signal transduction Skeletal muscle Transcription activation Transcription factors Vectors (Biology) Wnt protein Wnt Signaling Pathway - genetics β-Catenin
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