The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary specialization in eutherian mammals resulting in the emergence...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS biology 2022-04, Vol.20 (4), p.e3001615-e3001615
Hauptverfasser:	Spruce, Thomas, Plass, Mireya, Gohr, André, Ray, Debashish, Martínez de Lagrán, María, Rot, Gregor, Nóvoa, Ana, Burguera, Demian, Permanyer, Jon, Miret, Marta, Zheng, Hong, Swanson, Maurice S, Morris, Quaid, Mallo, Moises, Dierssen, Mara, Hughes, Timothy R, Pernaute, Barbara, Irimia, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - genetics Amino acid sequence Animals Binding Biological evolution Biology and Life Sciences Constraining Developmental biology Discovery Report Embryos Eutheria - genetics Eutherians Evolution Female Fetuses Gene expression Genetic aspects Localization Medicine and Health Sciences Metabolism Myc protein Nucleotide sequence Placenta Placenta - metabolism Polyadenylation Pregnancy Proteins Research and analysis methods Resource allocation Ribonucleic acid RNA RNA - metabolism RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Splicing Stem cells Vertebrates X chromosomes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!