COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis

Giardia duodenalis, the causative agent of giardiasis, is among the most important causes of waterborne diarrheal diseases around the world. Giardia infection may persist over extended periods with intestinal inflammation, although minimal. Cyclooxygenase (COX)-2 is well known as an important induce...

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Veröffentlicht in:	PLoS neglected tropical diseases 2022-04, Vol.16 (4), p.e0010402-e0010402
Hauptverfasser:	Zhao, Yudan, Yang, Yongwu, Liu, Min, Qin, Xuening, Yu, Xiran, Zhao, Huimin, Li, Xiaoyun, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Cell culture Cell Line COX-2 inhibitors Crosstalk Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Defence mechanisms Defense Diarrhea Dinoprostone - metabolism Extracellular signal-regulated kinase Giardia Giardia duodenalis Giardia lamblia - metabolism Giardiasis Humans IL-1β Infections Inflammation Inflammatory response Interleukin 6 Interleukin-6 - metabolism Lipopolysaccharides Macrophages Macrophages - metabolism MAP kinase Medicine and Health Sciences NF-kappa B NF-κB protein Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Parasites Pathogens Phosphorylation Prostaglandin E2 Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Signaling Tropical diseases Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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