A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant

Although efficacious vaccines have significantly reduced the morbidity and mortality of COVID-19, there remains an unmet medical need for treatment options, which monoclonal antibodies (mAbs) can potentially fill. This unmet need is exacerbated by the emergence and spread of SARS-CoV-2 variants of c...

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Veröffentlicht in:	PLoS pathogens 2022-04, Vol.18 (4), p.e1010465
Hauptverfasser:	Hingankar, Nitin, Deshpande, Suprit, Das, Payel, Rizvi, Zaigham Abbas, Wibmer, Constantinos Kurt, Mashilo, Poppy, Ansari, Mohammed Yousuf, Burns, Alison, Barman, Shawn, Zhao, Fangzhu, Mukherjee, Sohini, Torres, Jonathan L, Chattopadhyay, Souvick, Mehdi, Farha, Sutar, Jyoti, Rathore, Deepak Kumar, Pargai, Kamal, Singh, Janmejay, Sonar, Sudipta, Jakhar, Kamini, Dandotiya, Jyotsna, Bhattacharyya, Sankar, Mani, Shailendra, Samal, Sweety, Singh, Savita, Kshetrapal, Pallavi, Thiruvengadam, Ramachandran, Batra, Gaurav, Medigeshi, Guruprasad, Ward, Andrew B, Bhatnagar, Shinjini, Awasthi, Amit, Sok, Devin, Bhattacharya, Jayanta
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin Angiotensin-converting enzyme 2 Animals Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Antigen-antibody reactions Antigens Biology and life sciences Control Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 vaccines Disease transmission Epidemics Epitopes Health aspects HIV Hospitalization Human immunodeficiency virus Identification and classification India Infections Light Medicine and health sciences Mice Monoclonal antibodies Morbidity Mutation Neutralization Neutralizing Observations Pandemics Peptidyl-dipeptidase A Plasma Receptors Research and Analysis Methods SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein Therapeutic applications Transgenic mice Vaccines Viral diseases Virus attachment Viruses
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