Detection of residual and chemoresistant leukemic cells in an immune-competent mouse model of acute myeloid leukemia: Potential for unravelling their interactions with immunity

Acute myeloid leukemia (AML) is characterized by blocked differentiation and extensive proliferation of hematopoietic progenitors/precursors. Relapse is often observed after chemotherapy due to the presence of residual leukemic cells, which is also called minimal residual disease (MRD). Subclonal he...

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Veröffentlicht in:	PloS one 2022-04, Vol.17 (4), p.e0267508-e0267508
Hauptverfasser:	Mopin, Alexia, Leprêtre, Frédéric, Sebda, Shéhérazade, Villenet, Céline, Ben Khoud, Meriem, Figeac, Martin, Quesnel, Bruno, Brinster, Carine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Animal models Animals Antigens Biology and Life Sciences Cancer Cancer cells Chemotherapy Cytarabine - pharmacology Cytarabine - therapeutic use Disease Models, Animal Disease Progression Gene expression Health aspects Hemopoiesis Heterogeneity Humans Immune system Immunity (Disease) Laboratory animals Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Life Sciences Lymphocytes Measurement Medicine and Health Sciences Mice Minimal residual disease Modelling Mutation Neoplasm, Residual - diagnosis Patients Progenitor cells Proteins Reporter gene Research and Analysis Methods WT1 protein Xenografts Xenotransplantation
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