Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: A study based on TCGA database

MicroRNAs (miRNAs) are frequently deregulated in various types of cancer. While antisense oligonucleotides are used to block oncomiRs, delivery of tumour-suppressive miRNAs holds great potential as a potent anti-cancer strategy. Here, we aim to determine, and functionally analyse, miRNAs that are lo...

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Veröffentlicht in:	PloS one 2022-04, Vol.17 (4), p.e0267291-e0267291
Hauptverfasser:	Moradi, Sharif, Kamal, Aryan, Aboulkheyr Es, Hamidreza, Farhadi, Farnoosh, Ebrahimi, Marzieh, Chitsaz, Hamidreza, Sharifi-Zarchi, Ali, Baharvand, Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antisense oligonucleotides Biology and life sciences Breast cancer Cancer Cell growth Cell viability Computer engineering Databases, Factual Deregulation Developmental biology Diagnosis Enrichment Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Gene Ontology Genetic aspects Genomes Humans Liver cancer Medicine and Health Sciences Metastasis MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Muscles Neoplasms - genetics Oligonucleotides Preadipocyte factor 1 Prostate cancer Research and Analysis Methods Ribonucleic acid RNA Statistical analysis Statistical methods Stem cells Suppressors Tissues Tumors
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