Kingella kingae PilC1 and PilC2 are adhesive multifunctional proteins that promote bacterial adherence, twitching motility, DNA transformation, and pilus biogenesis

The gram-negative bacterium Kingella kingae is a leading cause of osteoarticular infections in young children and initiates infection by colonizing the oropharynx. Adherence to respiratory epithelial cells represents an initial step in the process of K. kingae colonization and is mediated in part by...

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Veröffentlicht in:	PLoS pathogens 2022-03, Vol.18 (3), p.e1010440-e1010440
Hauptverfasser:	Sacharok, Alexandra L, Porsch, Eric A, Yount, Taylor A, Keenan, Orlaith, St Geme, 3rd, Joseph W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adhesins Adhesins, Bacterial - genetics Adhesion Adhesives Bacterial Adhesion Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Biology and Life Sciences Biomedical materials Cell adhesion Cells Cellular proteins Child Child, Preschool Children Colonization Deletion Deoxyribonucleic acid DNA Domains Epithelial cells Epithelium Extracellular matrix Fimbriae Proteins - genetics Fimbriae Proteins - metabolism Fimbriae, Bacterial - genetics Fimbriae, Bacterial - metabolism Genetic aspects Genetic transformation Gonorrhea Gram-negative bacteria Health aspects Humans Infections Kingella kingae Kingella kingae - genetics Medicine and Health Sciences Motility Oropharynx Physical Sciences Pili Proteins Spectrum analysis Twitching
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