Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles

Thyroid hormone (TH) signaling plays critical roles during vertebrate development, including regulation of skeletal and cartilage growth. TH acts through its receptors (TRs), nuclear hormone receptors (NRs) that heterodimerize with Retinoid-X receptors (RXRs), to regulate gene expression. A defining...

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Veröffentlicht in:	PloS one 2022-04, Vol.17 (4), p.e0266946-e0266946
Hauptverfasser:	Mengeling, Brenda J, Vetter, Lara F, Furlow, J David
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Analysis Animals Antifouling substances Biology and Life Sciences Cartilage Cbfa-1 protein Cell division Cell proliferation Cytology Fertilization Frogs Gene expression Gene Expression Regulation, Developmental Helper cells Jaw Juveniles Larva Ligands Lymphocytes T Mandible Matrix metalloproteinase Medicine and Health Sciences Metalloproteinase Metamorphosis Metamorphosis, Biological - physiology Morphology Neurobiology Neurosciences Nuclear receptors Physiology Potentiation Properties Receptors Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - metabolism Research and Analysis Methods Retinoid X receptors Retinoid X Receptors - genetics Retinoids Retinoids - pharmacology Signaling Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - metabolism Tributyltin Triiodothyronine Vertebrates Xenopus laevis Xenopus laevis - genetics
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