Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. HDL exerts various protective functions on the cardiovascular system including anti-inflammatory activity by suppressing adhesion molecules expression in inflammation-induced endothelial cells. T...
Gespeichert in:
| Veröffentlicht in: | PloS one 2022-04, Vol.17 (4), p.e0266227-e0266227 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0266227 |
|---|---|
| container_issue | 4 |
| container_start_page | e0266227 |
| container_title | PloS one |
| container_volume | 17 |
| creator | Sarmadi, Negar Poustchi, Hossein Ali Yari, Fatemeh Radmard, Amir Reza Karami, Sara Pakdel, Abbas Shabani, Parisa Khaleghian, Ali |
| description | Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. HDL exerts various protective functions on the cardiovascular system including anti-inflammatory activity by suppressing adhesion molecules expression in inflammation-induced endothelial cells. This study was designed to search if the anti-inflammatory capacity of apolipoprotein B-depleted plasma (apoB-depleted plasma) is altered in NAFLD patients.
A total of 83 subjects including 42 NAFLD and 41 control subjects were included in this cross-sectional study. Anti-inflammatory function of HDL was determined as the ability of apoB-depleted plasma to inhibit tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs).
Incubation of inflammation-stimulated HUVECs with the NAFLD patients' apo-B depleted plasma led to higher levels of expression of adhesion molecules compared to the control subjects' plasma samples, reflecting an impaired anti-inflammatory capacity of apoB-depleted plasma in the NAFLD patients. Impaired anti-inflammatory capacity of apoB-depleted plasma was correlated with fatty liver and obesity indices. After adjustment with obesity indices, the association of anti-inflammatory capacity of apoB-depleted plasma with NAFLD remained significant.
Impaired anti-inflammatory activity of apoB-depleted plasma was independently associated with NAFLD. |
| doi_str_mv | 10.1371/journal.pone.0266227 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2649552173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A700233395</galeid><doaj_id>oai_doaj_org_article_8878824fbe7d4b65910f9fe34036ffde</doaj_id><sourcerecordid>A700233395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c622t-16e26c72adcc262da8c0f3dd4d42d3c40316af08f4fbe3747f00bc72367b37063</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLguhFxzRpk_ZGGBc_BhYW_LoNZ_IxkyFtapIuzr8343SXqeyF7UXD6fO-J-ckJ8uel2hREla-27nR92AXg-vVAmFKMWYPsvOyJbigGJGHJ-uz7EkIO4Rq0lD6ODsjdVUSROl55pZ9NIXptYWug-j8PtdjL6Jxfe50DoOzZnCDd1GZPv9QSDVYFZXMBwuhg9yE3HQDGJ9CCehdX4AVbptkItcQ4z635kb5XJqgIKin2SMNNqhn0_ci-_Hp4_fLL8XV9efV5fKqEKmOWJRUYSoYBikEplhCI5AmUlaywpKICpGSgkaNrvRaEVYxjdA68YSyNWGIkovs5dF3sC7wqVeBY1q1dY1LRhKxOhLSwY4P3nTg99yB4X8Dzm84-GiEVbxpWNPgQyomqzWt2xLpViuStkG1lip5vZ-yjetOSaH66MHOTOd_erPlG3fDW4QqRptk8GYy8O7XqELknQlCWQu9cuNx3-mhLUvoq3_Q-6ubqA2kAtL5upRXHEz5kiGECSFtnajFPVR6peqMSBdLmxSfCd7OBImJ6nfcwBgCX337-v_s9c85-_qE3SqwcRucHQ_3MMzB6ggK70LwSt81uUT8MBe33eCHueDTXCTZi9MDuhPdDgL5A8zvCT0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2649552173</pqid></control><display><type>article</type><title>Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Sarmadi, Negar ; Poustchi, Hossein ; Ali Yari, Fatemeh ; Radmard, Amir Reza ; Karami, Sara ; Pakdel, Abbas ; Shabani, Parisa ; Khaleghian, Ali</creator><creatorcontrib>Sarmadi, Negar ; Poustchi, Hossein ; Ali Yari, Fatemeh ; Radmard, Amir Reza ; Karami, Sara ; Pakdel, Abbas ; Shabani, Parisa ; Khaleghian, Ali</creatorcontrib><description>Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. HDL exerts various protective functions on the cardiovascular system including anti-inflammatory activity by suppressing adhesion molecules expression in inflammation-induced endothelial cells. This study was designed to search if the anti-inflammatory capacity of apolipoprotein B-depleted plasma (apoB-depleted plasma) is altered in NAFLD patients.
A total of 83 subjects including 42 NAFLD and 41 control subjects were included in this cross-sectional study. Anti-inflammatory function of HDL was determined as the ability of apoB-depleted plasma to inhibit tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs).
Incubation of inflammation-stimulated HUVECs with the NAFLD patients' apo-B depleted plasma led to higher levels of expression of adhesion molecules compared to the control subjects' plasma samples, reflecting an impaired anti-inflammatory capacity of apoB-depleted plasma in the NAFLD patients. Impaired anti-inflammatory capacity of apoB-depleted plasma was correlated with fatty liver and obesity indices. After adjustment with obesity indices, the association of anti-inflammatory capacity of apoB-depleted plasma with NAFLD remained significant.
Impaired anti-inflammatory activity of apoB-depleted plasma was independently associated with NAFLD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0266227</identifier><identifier>PMID: 35413066</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesion ; Anti-inflammatory agents ; Anti-Inflammatory Agents - blood ; Apolipoprotein B ; Apolipoproteins ; Apolipoproteins B - blood ; Biochemistry ; Biology and Life Sciences ; Blood pressure ; Cardiovascular diseases ; Cardiovascular system ; Care and treatment ; Carotid arteries ; Case-Control Studies ; Cell adhesion molecules ; Cholesterol ; Complications and side effects ; Coronary vessels ; Cross-Sectional Studies ; Depletion ; Diabetes ; Endothelial cells ; Fasting ; Fatty liver ; Gene expression ; Health aspects ; Health risks ; Hepatitis ; High density lipoprotein ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation ; Inflammation - blood ; Liver ; Liver diseases ; Medicine ; Medicine and Health Sciences ; Metabolic syndrome ; Non-alcoholic Fatty Liver Disease - blood ; Obesity ; Patient outcomes ; Physiological aspects ; Plasma ; Risk factors ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Ultrasonic imaging ; Umbilical vein</subject><ispartof>PloS one, 2022-04, Vol.17 (4), p.e0266227-e0266227</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Sarmadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Sarmadi et al 2022 Sarmadi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-16e26c72adcc262da8c0f3dd4d42d3c40316af08f4fbe3747f00bc72367b37063</citedby><cites>FETCH-LOGICAL-c622t-16e26c72adcc262da8c0f3dd4d42d3c40316af08f4fbe3747f00bc72367b37063</cites><orcidid>0000-0003-2345-9052</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004768/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004768/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35413066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarmadi, Negar</creatorcontrib><creatorcontrib>Poustchi, Hossein</creatorcontrib><creatorcontrib>Ali Yari, Fatemeh</creatorcontrib><creatorcontrib>Radmard, Amir Reza</creatorcontrib><creatorcontrib>Karami, Sara</creatorcontrib><creatorcontrib>Pakdel, Abbas</creatorcontrib><creatorcontrib>Shabani, Parisa</creatorcontrib><creatorcontrib>Khaleghian, Ali</creatorcontrib><title>Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. HDL exerts various protective functions on the cardiovascular system including anti-inflammatory activity by suppressing adhesion molecules expression in inflammation-induced endothelial cells. This study was designed to search if the anti-inflammatory capacity of apolipoprotein B-depleted plasma (apoB-depleted plasma) is altered in NAFLD patients.
A total of 83 subjects including 42 NAFLD and 41 control subjects were included in this cross-sectional study. Anti-inflammatory function of HDL was determined as the ability of apoB-depleted plasma to inhibit tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs).
Incubation of inflammation-stimulated HUVECs with the NAFLD patients' apo-B depleted plasma led to higher levels of expression of adhesion molecules compared to the control subjects' plasma samples, reflecting an impaired anti-inflammatory capacity of apoB-depleted plasma in the NAFLD patients. Impaired anti-inflammatory capacity of apoB-depleted plasma was correlated with fatty liver and obesity indices. After adjustment with obesity indices, the association of anti-inflammatory capacity of apoB-depleted plasma with NAFLD remained significant.
Impaired anti-inflammatory activity of apoB-depleted plasma was independently associated with NAFLD.</description><subject>Adhesion</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - blood</subject><subject>Apolipoprotein B</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins B - blood</subject><subject>Biochemistry</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular system</subject><subject>Care and treatment</subject><subject>Carotid arteries</subject><subject>Case-Control Studies</subject><subject>Cell adhesion molecules</subject><subject>Cholesterol</subject><subject>Complications and side effects</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Depletion</subject><subject>Diabetes</subject><subject>Endothelial cells</subject><subject>Fasting</subject><subject>Fatty liver</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>High density lipoprotein</subject><subject>Human Umbilical Vein Endothelial Cells</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic syndrome</subject><subject>Non-alcoholic Fatty Liver Disease - blood</subject><subject>Obesity</subject><subject>Patient outcomes</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Risk factors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Ultrasonic imaging</subject><subject>Umbilical vein</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguhFxzRpk_ZGGBc_BhYW_LoNZ_IxkyFtapIuzr8343SXqeyF7UXD6fO-J-ckJ8uel2hREla-27nR92AXg-vVAmFKMWYPsvOyJbigGJGHJ-uz7EkIO4Rq0lD6ODsjdVUSROl55pZ9NIXptYWug-j8PtdjL6Jxfe50DoOzZnCDd1GZPv9QSDVYFZXMBwuhg9yE3HQDGJ9CCehdX4AVbptkItcQ4z635kb5XJqgIKin2SMNNqhn0_ci-_Hp4_fLL8XV9efV5fKqEKmOWJRUYSoYBikEplhCI5AmUlaywpKICpGSgkaNrvRaEVYxjdA68YSyNWGIkovs5dF3sC7wqVeBY1q1dY1LRhKxOhLSwY4P3nTg99yB4X8Dzm84-GiEVbxpWNPgQyomqzWt2xLpViuStkG1lip5vZ-yjetOSaH66MHOTOd_erPlG3fDW4QqRptk8GYy8O7XqELknQlCWQu9cuNx3-mhLUvoq3_Q-6ubqA2kAtL5upRXHEz5kiGECSFtnajFPVR6peqMSBdLmxSfCd7OBImJ6nfcwBgCX337-v_s9c85-_qE3SqwcRucHQ_3MMzB6ggK70LwSt81uUT8MBe33eCHueDTXCTZi9MDuhPdDgL5A8zvCT0</recordid><startdate>20220412</startdate><enddate>20220412</enddate><creator>Sarmadi, Negar</creator><creator>Poustchi, Hossein</creator><creator>Ali Yari, Fatemeh</creator><creator>Radmard, Amir Reza</creator><creator>Karami, Sara</creator><creator>Pakdel, Abbas</creator><creator>Shabani, Parisa</creator><creator>Khaleghian, Ali</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2345-9052</orcidid></search><sort><creationdate>20220412</creationdate><title>Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease</title><author>Sarmadi, Negar ; Poustchi, Hossein ; Ali Yari, Fatemeh ; Radmard, Amir Reza ; Karami, Sara ; Pakdel, Abbas ; Shabani, Parisa ; Khaleghian, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-16e26c72adcc262da8c0f3dd4d42d3c40316af08f4fbe3747f00bc72367b37063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adhesion</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents - blood</topic><topic>Apolipoprotein B</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins B - blood</topic><topic>Biochemistry</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular system</topic><topic>Care and treatment</topic><topic>Carotid arteries</topic><topic>Case-Control Studies</topic><topic>Cell adhesion molecules</topic><topic>Cholesterol</topic><topic>Complications and side effects</topic><topic>Coronary vessels</topic><topic>Cross-Sectional Studies</topic><topic>Depletion</topic><topic>Diabetes</topic><topic>Endothelial cells</topic><topic>Fasting</topic><topic>Fatty liver</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Hepatitis</topic><topic>High density lipoprotein</topic><topic>Human Umbilical Vein Endothelial Cells</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic syndrome</topic><topic>Non-alcoholic Fatty Liver Disease - blood</topic><topic>Obesity</topic><topic>Patient outcomes</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>Risk factors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Ultrasonic imaging</topic><topic>Umbilical vein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarmadi, Negar</creatorcontrib><creatorcontrib>Poustchi, Hossein</creatorcontrib><creatorcontrib>Ali Yari, Fatemeh</creatorcontrib><creatorcontrib>Radmard, Amir Reza</creatorcontrib><creatorcontrib>Karami, Sara</creatorcontrib><creatorcontrib>Pakdel, Abbas</creatorcontrib><creatorcontrib>Shabani, Parisa</creatorcontrib><creatorcontrib>Khaleghian, Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarmadi, Negar</au><au>Poustchi, Hossein</au><au>Ali Yari, Fatemeh</au><au>Radmard, Amir Reza</au><au>Karami, Sara</au><au>Pakdel, Abbas</au><au>Shabani, Parisa</au><au>Khaleghian, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-04-12</date><risdate>2022</risdate><volume>17</volume><issue>4</issue><spage>e0266227</spage><epage>e0266227</epage><pages>e0266227-e0266227</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. HDL exerts various protective functions on the cardiovascular system including anti-inflammatory activity by suppressing adhesion molecules expression in inflammation-induced endothelial cells. This study was designed to search if the anti-inflammatory capacity of apolipoprotein B-depleted plasma (apoB-depleted plasma) is altered in NAFLD patients.
A total of 83 subjects including 42 NAFLD and 41 control subjects were included in this cross-sectional study. Anti-inflammatory function of HDL was determined as the ability of apoB-depleted plasma to inhibit tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs).
Incubation of inflammation-stimulated HUVECs with the NAFLD patients' apo-B depleted plasma led to higher levels of expression of adhesion molecules compared to the control subjects' plasma samples, reflecting an impaired anti-inflammatory capacity of apoB-depleted plasma in the NAFLD patients. Impaired anti-inflammatory capacity of apoB-depleted plasma was correlated with fatty liver and obesity indices. After adjustment with obesity indices, the association of anti-inflammatory capacity of apoB-depleted plasma with NAFLD remained significant.
Impaired anti-inflammatory activity of apoB-depleted plasma was independently associated with NAFLD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35413066</pmid><doi>10.1371/journal.pone.0266227</doi><tpages>e0266227</tpages><orcidid>https://orcid.org/0000-0003-2345-9052</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-04, Vol.17 (4), p.e0266227-e0266227 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2649552173 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adhesion Anti-inflammatory agents Anti-Inflammatory Agents - blood Apolipoprotein B Apolipoproteins Apolipoproteins B - blood Biochemistry Biology and Life Sciences Blood pressure Cardiovascular diseases Cardiovascular system Care and treatment Carotid arteries Case-Control Studies Cell adhesion molecules Cholesterol Complications and side effects Coronary vessels Cross-Sectional Studies Depletion Diabetes Endothelial cells Fasting Fatty liver Gene expression Health aspects Health risks Hepatitis High density lipoprotein Human Umbilical Vein Endothelial Cells Humans Inflammation Inflammation - blood Liver Liver diseases Medicine Medicine and Health Sciences Metabolic syndrome Non-alcoholic Fatty Liver Disease - blood Obesity Patient outcomes Physiological aspects Plasma Risk factors Tumor necrosis factor-TNF Tumor necrosis factor-α Ultrasonic imaging Umbilical vein |
| title | Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A09%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-inflammatory%20function%20of%20apolipoprotein%20B-depleted%20plasma%20is%20impaired%20in%20non-alcoholic%20fatty%20liver%20disease&rft.jtitle=PloS%20one&rft.au=Sarmadi,%20Negar&rft.date=2022-04-12&rft.volume=17&rft.issue=4&rft.spage=e0266227&rft.epage=e0266227&rft.pages=e0266227-e0266227&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0266227&rft_dat=%3Cgale_plos_%3EA700233395%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2649552173&rft_id=info:pmid/35413066&rft_galeid=A700233395&rft_doaj_id=oai_doaj_org_article_8878824fbe7d4b65910f9fe34036ffde&rfr_iscdi=true |