The efficacy and safety of cardio-protective therapy in patients with 5-FU (Fluorouracil)-associated coronary vasospasm

Coronary vasospasm is a known side effect of 5-FU (fluorouracil) therapy. Beyond switching to non-5FU-based chemotherapy, there are no established treatments for 5-FU associated coronary vasospam. Our objective was to assess the safety and efficacy of re-challenge with 5-FU after pre-treatment with...

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Veröffentlicht in:	PloS one 2022-04, Vol.17 (4), p.e0265767-e0265767
Hauptverfasser:	Zafar, Amna, Drobni, Zsofia D, Lei, Matthew, Gongora, Carlos A, Quinaglia, Thiago, Lou, Uvette Y, Mosarla, Ramya, Murphy, Sean P, Jones-O'Connor, Maeve, Mahmood, Ali, Hartmann, Sarah, Gilman, Hannah K, Weekes, Colin D, Nipp, Ryan, Clark, John R, Clark, Jeffrey W, Blaszkowsky, Lawrence S, Tavares, Erica, Neilan, Tomas G
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Biology and Life Sciences Calcium channel blockers Calcium Channel Blockers - therapeutic use Calcium channels Cardiology Cardiotoxicity Cardiovascular disease Care and treatment Chemotherapy Colorectal cancer Complications and side effects Coronary heart disease Coronary Vasospasm - chemically induced Coronary Vasospasm - drug therapy Coronary vessels Drug dosages Fluorouracil Fluorouracil - adverse effects Gastrointestinal cancer Heart Hematology Hospitals Humans Medical schools Medicine Medicine and Health Sciences Myocardial infarction Neoplasms - drug therapy Nitrates Nitrates - therapeutic use Oncology Pain Patient outcomes Patients Physical Sciences Pretreatment Retrospective Studies Safety Survival Variables Vasoconstriction
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