A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data
Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic toxicity data on adult and larval honey bees (Apis m...
Gespeichert in:
| Veröffentlicht in: | PloS one 2022-04, Vol.17 (4), p.e0265962-e0265962 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0265962 |
|---|---|
| container_issue | 4 |
| container_start_page | e0265962 |
| container_title | PloS one |
| container_volume | 17 |
| creator | Farruggia, Frank T Garber, Kristina Hartless, Christine Jones, Kristin Kyle, Lee Mastrota, Nicholas Milone, Joseph P Sankula, Sujatha Sappington, Keith Stebbins, Katherine Steeger, Thomas Summers, Holly Thompson, Pamela G Wagman, Michael |
| description | Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic toxicity data on adult and larval honey bees (Apis mellifera), which USEPA considers a surrogate for Apis and non-Apis bees. We compared these toxicity data to explore possible trends. This analysis indicated a significant correlation between acute contact and oral median lethal dose (LD50) values for adult honey bees (ρ = 0.74, p |
| doi_str_mv | 10.1371/journal.pone.0265962 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2648291382</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A699719774</galeid><doaj_id>oai_doaj_org_article_5c75eba30b014f21ace5d2cfb94c105f</doaj_id><sourcerecordid>A699719774</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5082-562ff06355f366e0a85890d845d93defec036b980a4adab1bbbd7836e24182933</originalsourceid><addsrcrecordid>eNptUk1vEzEQtRCIlsA_QLASl3JI8Mfaa1-QooqPShVc4Gx57XHqaHe92JuK_HucZls1qPLB1sybN2_GD6G3BK8Ia8inbdylwXSrMQ6wwlRwJegzdE4Uo0tBMXv-6H2GXuW8xZgzKcRLdMY4UxgTco5-rKsEU4p5BDuFW6hM4dznkKvoq5tCva9agOpiPZZQD10XPCTzsRohT8EGB9UU_5bHtK-cmcxr9MKbLsOb-V6g31-__Lr8vrz--e3qcn29tBxLuuSCeo8F49wzIQAbyaXCTtbcKebAg8VMtEpiUxtnWtK2rWskE0BrIqlibIHeH3nHLmY9ryJrKuqSJkzSgrg6Ilw0Wz2m0Ju019EEfReIaaNNKiN0oLltOLSG4RaT2lNiLHBHrW9VbQkuEhfo89xt1_bgLAxTMt0J6WlmCDd6E2-1VFKRO7kXM0GKf3ZldboP2ZZtmgHi7qhbYSplXaAf_oM-Pd2M2pgyQBh8LH3tgVSvhVINUU1z4Fo9gSrHQR9s-VwfSvykoD4W2OKInMA_zEiwPrjuXow-uE7Pritl7x7v56Ho3mbsH3n30-o</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2648291382</pqid></control><display><type>article</type><title>A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Farruggia, Frank T ; Garber, Kristina ; Hartless, Christine ; Jones, Kristin ; Kyle, Lee ; Mastrota, Nicholas ; Milone, Joseph P ; Sankula, Sujatha ; Sappington, Keith ; Stebbins, Katherine ; Steeger, Thomas ; Summers, Holly ; Thompson, Pamela G ; Wagman, Michael</creator><creatorcontrib>Farruggia, Frank T ; Garber, Kristina ; Hartless, Christine ; Jones, Kristin ; Kyle, Lee ; Mastrota, Nicholas ; Milone, Joseph P ; Sankula, Sujatha ; Sappington, Keith ; Stebbins, Katherine ; Steeger, Thomas ; Summers, Holly ; Thompson, Pamela G ; Wagman, Michael</creatorcontrib><description>Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic toxicity data on adult and larval honey bees (Apis mellifera), which USEPA considers a surrogate for Apis and non-Apis bees. We compared these toxicity data to explore possible trends. This analysis indicated a significant correlation between acute contact and oral median lethal dose (LD50) values for adult honey bees (ρ = 0.74, p <0.0001). Using default EPA modeling assumptions, where exposure for an individual bee is roughly 12x lower through contact than through ingestion, the analysis indicates that the oral LD50 is similarly if not more protective of the contact LD50 for the majority of pesticides and modes of action evaluated. The analysis also provided evidence that compounds with a lower acute toxicity for adults through contact and oral exposure pathways may still be acutely toxic for larvae. The acute toxicity of herbicides and fungicides was higher for larvae relative to oral and contact toxicity for adult honey bees for the same compounds and the no observed adverse effect level (NOAEL) from chronic toxicity studies were lower for larvae relative to adults, indicating increased sensitivity of larvae. When comparing 8-day LD50 values between single dose larval acute studies to those derived from repeat dose 22-day larval chronic toxicity studies, the LD50 values derived from chronic studies were significantly lower than those from acute toxicity tests (Z = -37, p = 0.03).</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0265962</identifier><identifier>PMID: 35390011</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute toxicity ; Adults ; Agricultural production ; Analysis ; Animals ; Apis mellifera ; Bees ; Biology and Life Sciences ; Chronic toxicity ; Ecological risk assessment ; Environmental protection ; Environmental risk ; Evaluation ; Fungicides ; Herbicides ; Honey ; Honeybee ; Ingestion ; Laboratories ; Larva ; Larvae ; Lethal dose ; Lethal Dose 50 ; Medicine and Health Sciences ; Pesticide toxicity ; Pesticides ; Pesticides - toxicity ; Plant reproduction ; Pollinators ; Retrospective Studies ; Risk assessment ; Toxicity testing ; Toxicity Tests, Acute ; Toxicology</subject><ispartof>PloS one, 2022-04, Vol.17 (4), p.e0265962-e0265962</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5082-562ff06355f366e0a85890d845d93defec036b980a4adab1bbbd7836e24182933</citedby><cites>FETCH-LOGICAL-c5082-562ff06355f366e0a85890d845d93defec036b980a4adab1bbbd7836e24182933</cites><orcidid>0000-0002-5768-0399</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8989193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35390011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farruggia, Frank T</creatorcontrib><creatorcontrib>Garber, Kristina</creatorcontrib><creatorcontrib>Hartless, Christine</creatorcontrib><creatorcontrib>Jones, Kristin</creatorcontrib><creatorcontrib>Kyle, Lee</creatorcontrib><creatorcontrib>Mastrota, Nicholas</creatorcontrib><creatorcontrib>Milone, Joseph P</creatorcontrib><creatorcontrib>Sankula, Sujatha</creatorcontrib><creatorcontrib>Sappington, Keith</creatorcontrib><creatorcontrib>Stebbins, Katherine</creatorcontrib><creatorcontrib>Steeger, Thomas</creatorcontrib><creatorcontrib>Summers, Holly</creatorcontrib><creatorcontrib>Thompson, Pamela G</creatorcontrib><creatorcontrib>Wagman, Michael</creatorcontrib><title>A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic toxicity data on adult and larval honey bees (Apis mellifera), which USEPA considers a surrogate for Apis and non-Apis bees. We compared these toxicity data to explore possible trends. This analysis indicated a significant correlation between acute contact and oral median lethal dose (LD50) values for adult honey bees (ρ = 0.74, p <0.0001). Using default EPA modeling assumptions, where exposure for an individual bee is roughly 12x lower through contact than through ingestion, the analysis indicates that the oral LD50 is similarly if not more protective of the contact LD50 for the majority of pesticides and modes of action evaluated. The analysis also provided evidence that compounds with a lower acute toxicity for adults through contact and oral exposure pathways may still be acutely toxic for larvae. The acute toxicity of herbicides and fungicides was higher for larvae relative to oral and contact toxicity for adult honey bees for the same compounds and the no observed adverse effect level (NOAEL) from chronic toxicity studies were lower for larvae relative to adults, indicating increased sensitivity of larvae. When comparing 8-day LD50 values between single dose larval acute studies to those derived from repeat dose 22-day larval chronic toxicity studies, the LD50 values derived from chronic studies were significantly lower than those from acute toxicity tests (Z = -37, p = 0.03).</description><subject>Acute toxicity</subject><subject>Adults</subject><subject>Agricultural production</subject><subject>Analysis</subject><subject>Animals</subject><subject>Apis mellifera</subject><subject>Bees</subject><subject>Biology and Life Sciences</subject><subject>Chronic toxicity</subject><subject>Ecological risk assessment</subject><subject>Environmental protection</subject><subject>Environmental risk</subject><subject>Evaluation</subject><subject>Fungicides</subject><subject>Herbicides</subject><subject>Honey</subject><subject>Honeybee</subject><subject>Ingestion</subject><subject>Laboratories</subject><subject>Larva</subject><subject>Larvae</subject><subject>Lethal dose</subject><subject>Lethal Dose 50</subject><subject>Medicine and Health Sciences</subject><subject>Pesticide toxicity</subject><subject>Pesticides</subject><subject>Pesticides - toxicity</subject><subject>Plant reproduction</subject><subject>Pollinators</subject><subject>Retrospective Studies</subject><subject>Risk assessment</subject><subject>Toxicity testing</subject><subject>Toxicity Tests, Acute</subject><subject>Toxicology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1vEzEQtRCIlsA_QLASl3JI8Mfaa1-QooqPShVc4Gx57XHqaHe92JuK_HucZls1qPLB1sybN2_GD6G3BK8Ia8inbdylwXSrMQ6wwlRwJegzdE4Uo0tBMXv-6H2GXuW8xZgzKcRLdMY4UxgTco5-rKsEU4p5BDuFW6hM4dznkKvoq5tCva9agOpiPZZQD10XPCTzsRohT8EGB9UU_5bHtK-cmcxr9MKbLsOb-V6g31-__Lr8vrz--e3qcn29tBxLuuSCeo8F49wzIQAbyaXCTtbcKebAg8VMtEpiUxtnWtK2rWskE0BrIqlibIHeH3nHLmY9ryJrKuqSJkzSgrg6Ilw0Wz2m0Ju019EEfReIaaNNKiN0oLltOLSG4RaT2lNiLHBHrW9VbQkuEhfo89xt1_bgLAxTMt0J6WlmCDd6E2-1VFKRO7kXM0GKf3ZldboP2ZZtmgHi7qhbYSplXaAf_oM-Pd2M2pgyQBh8LH3tgVSvhVINUU1z4Fo9gSrHQR9s-VwfSvykoD4W2OKInMA_zEiwPrjuXow-uE7Pritl7x7v56Ho3mbsH3n30-o</recordid><startdate>20220407</startdate><enddate>20220407</enddate><creator>Farruggia, Frank T</creator><creator>Garber, Kristina</creator><creator>Hartless, Christine</creator><creator>Jones, Kristin</creator><creator>Kyle, Lee</creator><creator>Mastrota, Nicholas</creator><creator>Milone, Joseph P</creator><creator>Sankula, Sujatha</creator><creator>Sappington, Keith</creator><creator>Stebbins, Katherine</creator><creator>Steeger, Thomas</creator><creator>Summers, Holly</creator><creator>Thompson, Pamela G</creator><creator>Wagman, Michael</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5768-0399</orcidid></search><sort><creationdate>20220407</creationdate><title>A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data</title><author>Farruggia, Frank T ; Garber, Kristina ; Hartless, Christine ; Jones, Kristin ; Kyle, Lee ; Mastrota, Nicholas ; Milone, Joseph P ; Sankula, Sujatha ; Sappington, Keith ; Stebbins, Katherine ; Steeger, Thomas ; Summers, Holly ; Thompson, Pamela G ; Wagman, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5082-562ff06355f366e0a85890d845d93defec036b980a4adab1bbbd7836e24182933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute toxicity</topic><topic>Adults</topic><topic>Agricultural production</topic><topic>Analysis</topic><topic>Animals</topic><topic>Apis mellifera</topic><topic>Bees</topic><topic>Biology and Life Sciences</topic><topic>Chronic toxicity</topic><topic>Ecological risk assessment</topic><topic>Environmental protection</topic><topic>Environmental risk</topic><topic>Evaluation</topic><topic>Fungicides</topic><topic>Herbicides</topic><topic>Honey</topic><topic>Honeybee</topic><topic>Ingestion</topic><topic>Laboratories</topic><topic>Larva</topic><topic>Larvae</topic><topic>Lethal dose</topic><topic>Lethal Dose 50</topic><topic>Medicine and Health Sciences</topic><topic>Pesticide toxicity</topic><topic>Pesticides</topic><topic>Pesticides - toxicity</topic><topic>Plant reproduction</topic><topic>Pollinators</topic><topic>Retrospective Studies</topic><topic>Risk assessment</topic><topic>Toxicity testing</topic><topic>Toxicity Tests, Acute</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farruggia, Frank T</creatorcontrib><creatorcontrib>Garber, Kristina</creatorcontrib><creatorcontrib>Hartless, Christine</creatorcontrib><creatorcontrib>Jones, Kristin</creatorcontrib><creatorcontrib>Kyle, Lee</creatorcontrib><creatorcontrib>Mastrota, Nicholas</creatorcontrib><creatorcontrib>Milone, Joseph P</creatorcontrib><creatorcontrib>Sankula, Sujatha</creatorcontrib><creatorcontrib>Sappington, Keith</creatorcontrib><creatorcontrib>Stebbins, Katherine</creatorcontrib><creatorcontrib>Steeger, Thomas</creatorcontrib><creatorcontrib>Summers, Holly</creatorcontrib><creatorcontrib>Thompson, Pamela G</creatorcontrib><creatorcontrib>Wagman, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farruggia, Frank T</au><au>Garber, Kristina</au><au>Hartless, Christine</au><au>Jones, Kristin</au><au>Kyle, Lee</au><au>Mastrota, Nicholas</au><au>Milone, Joseph P</au><au>Sankula, Sujatha</au><au>Sappington, Keith</au><au>Stebbins, Katherine</au><au>Steeger, Thomas</au><au>Summers, Holly</au><au>Thompson, Pamela G</au><au>Wagman, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-04-07</date><risdate>2022</risdate><volume>17</volume><issue>4</issue><spage>e0265962</spage><epage>e0265962</epage><pages>e0265962-e0265962</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Current USEPA ecological risk assessments for pesticide registration include a determination of potential risks to bees. Toxicity data are submitted to support these assessments and the USEPA maintains a large database containing acute and chronic toxicity data on adult and larval honey bees (Apis mellifera), which USEPA considers a surrogate for Apis and non-Apis bees. We compared these toxicity data to explore possible trends. This analysis indicated a significant correlation between acute contact and oral median lethal dose (LD50) values for adult honey bees (ρ = 0.74, p <0.0001). Using default EPA modeling assumptions, where exposure for an individual bee is roughly 12x lower through contact than through ingestion, the analysis indicates that the oral LD50 is similarly if not more protective of the contact LD50 for the majority of pesticides and modes of action evaluated. The analysis also provided evidence that compounds with a lower acute toxicity for adults through contact and oral exposure pathways may still be acutely toxic for larvae. The acute toxicity of herbicides and fungicides was higher for larvae relative to oral and contact toxicity for adult honey bees for the same compounds and the no observed adverse effect level (NOAEL) from chronic toxicity studies were lower for larvae relative to adults, indicating increased sensitivity of larvae. When comparing 8-day LD50 values between single dose larval acute studies to those derived from repeat dose 22-day larval chronic toxicity studies, the LD50 values derived from chronic studies were significantly lower than those from acute toxicity tests (Z = -37, p = 0.03).</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35390011</pmid><doi>10.1371/journal.pone.0265962</doi><orcidid>https://orcid.org/0000-0002-5768-0399</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-04, Vol.17 (4), p.e0265962-e0265962 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2648291382 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acute toxicity Adults Agricultural production Analysis Animals Apis mellifera Bees Biology and Life Sciences Chronic toxicity Ecological risk assessment Environmental protection Environmental risk Evaluation Fungicides Herbicides Honey Honeybee Ingestion Laboratories Larva Larvae Lethal dose Lethal Dose 50 Medicine and Health Sciences Pesticide toxicity Pesticides Pesticides - toxicity Plant reproduction Pollinators Retrospective Studies Risk assessment Toxicity testing Toxicity Tests, Acute Toxicology |
| title | A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T14%3A15%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20retrospective%20analysis%20of%20honey%20bee%20(Apis%20mellifera)%20pesticide%20toxicity%20data&rft.jtitle=PloS%20one&rft.au=Farruggia,%20Frank%20T&rft.date=2022-04-07&rft.volume=17&rft.issue=4&rft.spage=e0265962&rft.epage=e0265962&rft.pages=e0265962-e0265962&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0265962&rft_dat=%3Cgale_plos_%3EA699719774%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2648291382&rft_id=info:pmid/35390011&rft_galeid=A699719774&rft_doaj_id=oai_doaj_org_article_5c75eba30b014f21ace5d2cfb94c105f&rfr_iscdi=true |