FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

Conjunctival squamous cell carcinoma (SCC) is the most common ocular surface neoplasia. The purpose of this retrospective study was to examine the role of regulatory T cell (Treg) activity in tumor immunity and investigate the tumor microenvironment as a new treatment focus in conjunctival SCC. Canc...

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Veröffentlicht in:	PloS one 2022-03, Vol.17 (3), p.e0263895-e0263895
Hauptverfasser:	Tagami, Mizuki, Kakehashi, Anna, Katsuyama-Yoshikawa, Atsuko, Misawa, Norihiko, Sakai, Atsushi, Wanibuchi, Hideki, Azumi, Atsushi, Honda, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biology and life sciences Cancer Carcinoma, Squamous Cell - immunology Care and treatment CD8 antigen CD8-Positive T-Lymphocytes Cloning Conjunctival Neoplasms - immunology CXCR4 protein Forkhead Transcription Factors - metabolism Foxp3 protein Gene expression Genetic aspects Health aspects Hospitals Humans Immunity Immunoregulation Laboratories Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating Markers Medicine Medicine and Health Sciences Muscles Ophthalmology Pathology PD-L1 protein Prognosis Receptors, CXCR4 - metabolism Research and Analysis Methods Retrospective Studies Smooth muscle Squamous cell carcinoma Staining Stromal cells T cells T-Lymphocytes, Regulatory Tumor cells Tumor Microenvironment Tumor-infiltrating lymphocytes Tumors
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