Phylogenetic inference of changes in amino acid propensities with single-position resolution

Fitness conferred by the same allele may differ between genotypes and environments, and these differences shape variation and evolution. Changes in amino acid propensities at protein sites over the course of evolution have been inferred from sequence alignments statistically, but the existing method...

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Veröffentlicht in:	PLoS computational biology 2022-02, Vol.18 (2), p.e1009878-e1009878
Hauptverfasser:	Klink, Galya V, Kalinina, Olga V, Bazykin, Georgii A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Amino acids Amino Acids - genetics Biology and Life Sciences Computer and Information Sciences Env gene Env protein Evolution Evolution, Molecular Experiments Fitness Genotypes HIV Human immunodeficiency virus Humans Influenza Influenza A Influenza, Human - genetics Medicine and Health Sciences Mutation Phylogenetics Phylogeny Physical Sciences Physiological aspects Physiological research Positive selection Proteins Reproductive fitness Research and Analysis Methods Sequence Alignment Simulated evolution Simulation Standard deviation
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