Obesity and risk of female reproductive conditions: A Mendelian randomisation study

Obesity is observationally associated with altered risk of many female reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal uterine bleeding, endometriosis, infertility, and pregnancy-related disorders. However, the roles and mechanisms of obesity in the aetiology of rep...

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Veröffentlicht in:	PLoS medicine 2022-02, Vol.19 (2), p.e1003679
Hauptverfasser:	Venkatesh, Samvida S, Ferreira, Teresa, Benonisdottir, Stefania, Rahmioglu, Nilufer, Becker, Christian M, Granne, Ingrid, Zondervan, Krina T, Holmes, Michael V, Lindgren, Cecilia M, Wittemans, Laura B L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adult Age Aged Bias Biobanks Biology and Life Sciences Bleeding Body fat Body mass index Body weight Complications and side effects Development and progression Disease Endometriosis Epidemiology Female Females Fibroids Genome-Wide Association Study Genomes Gynecology Health aspects Hip Humans Infertility Infertility, Female Insulin Insulin resistance Leiomyoma - epidemiology Leiomyoma - etiology Leiomyoma - genetics Leptin Medicine and Health Sciences Mendelian Randomization Analysis Menstruation Metabolism Middle Aged Miscarriage Obesity Obesity - complications Obesity - epidemiology Obesity - genetics Overweight Peer review Physiological aspects Pleiotropy Polycystic ovary syndrome Polycystic Ovary Syndrome - epidemiology Polycystic Ovary Syndrome - etiology Polycystic Ovary Syndrome - genetics Pre-eclampsia Pre-Eclampsia - epidemiology Pre-Eclampsia - etiology Pre-Eclampsia - genetics Preeclampsia Pregnancy Regression analysis Reproductive system Risk Assessment Risk factors United Kingdom - epidemiology Uterine Hemorrhage - epidemiology Uterine Hemorrhage - etiology Uterine Hemorrhage - genetics Uterus Womens health
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