Quantifying cumulative phenotypic and genomic evidence for procedural generation of metabolic network reconstructions

Genome-scale metabolic network reconstructions (GENREs) are valuable tools for understanding microbial metabolism. The process of automatically generating GENREs includes identifying metabolic reactions supported by sufficient genomic evidence to generate a draft metabolic network. The draft GENRE i...

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Veröffentlicht in:	PLoS computational biology 2022-02, Vol.18 (2), p.e1009341-e1009341
Hauptverfasser:	Moutinho, Jr, Thomas J, Neubert, Benjamin C, Jenior, Matthew L, Papin, Jason A
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Biochemistry Biology and Life Sciences Computer and Information Sciences Construction Datasets E coli Escherichia coli - genetics Gene expression Gene mapping Genes, Bacterial Genetic aspects Genomes Genomics Mathematical models Metabolic networks Metabolic Networks and Pathways Metabolism Metabolites Methods Microbial metabolism Microorganisms Model accuracy Models, Biological Networks Optimization Phenotype Phenotypes Redundancy Regulatory mechanisms (biology) Research and Analysis Methods Uncertainty
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