Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death

The Pseudomonas aeruginosa toxin ExoS, secreted by the type III secretion system (T3SS), supports intracellular persistence via its ADP-ribosyltransferase (ADPr) activity. For epithelial cells, this involves inhibiting vacuole acidification, promoting vacuolar escape, countering autophagy, and niche...

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Veröffentlicht in:	PLoS pathogens 2022-02, Vol.18 (2), p.e1010306
Hauptverfasser:	Kroken, Abby R, Gajenthra Kumar, Naren, Yahr, Timothy L, Smith, Benjamin E, Nieto, Vincent, Horneman, Hart, Evans, David J, Fleiszig, Suzanne M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification ADP Ribose Transferases - metabolism Analysis Anti-Bacterial Agents - pharmacology Antibiotics Apoptosis Autophagy Bacteria Bacterial Proteins - metabolism Bacterial Toxins - metabolism Biology and Life Sciences Cell Death Cell Membrane Permeability Cell membranes Chemical properties Cornea Cytoplasm Cytotoxicity Effectors Epithelial cells Epithelial Cells - metabolism Epithelial Cells - microbiology Epithelium Exotoxins Exotoxins - metabolism Genotype & phenotype GTPase-Activating Proteins - metabolism Health aspects HeLa Cells Host-Pathogen Interactions Humans Internalization Intracellular Labeling Medicine and Health Sciences Membrane permeability Mortality Mutants Mutation Nosocomial infections Pathogenesis Pathogens Phenotypes Physiological aspects Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Pseudomonas Infections - microbiology Research and analysis methods Rhamnose Toxins Type III Secretion Systems - metabolism Vacuoles - metabolism
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