Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung

The continuous emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2) variants and the increasing number of breakthrough infection cases among vaccinated people support the urgent need for research and development of antiviral drugs. Viral entry is an intriguing target for antiviral drug d...

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Veröffentlicht in:	PLoS pathogens 2022-02, Vol.18 (2), p.e1010343
Hauptverfasser:	Wang, Xinxin, Luo, Jie, Wen, Zhiyuan, Shuai, Lei, Wang, Chong, Zhong, Gongxun, He, Xijun, Cao, Huizhen, Liu, Renqiang, Ge, Jinying, Hua, Ronghong, Sun, Ziruo, Wang, Xijun, Wang, Jinliang, Bu, Zhigao
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells ACE2 Angiotensin-converting enzyme 2 Animals Antibodies Antiviral agents Biology and life sciences Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Cell adhesion Cells, Cultured Chlorocebus aethiops Coronaviruses COVID-19 COVID-19 - pathology COVID-19 - virology COVID-19 Drug Treatment Cytotoxicity Diltiazem Diltiazem - pharmacology Diltiazem - therapeutic use Disease Models, Animal Dosage and administration Drug development Drugs Engineering and Technology Female HEK293 Cells HeLa Cells Humans Infections Internalization Lung - drug effects Lung - pathology Lung - virology Lungs Medicine and health sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Physical Sciences Pore formation Proteins R&D Research & development Research and Analysis Methods Respiratory diseases SARS-CoV-2 - drug effects SARS-CoV-2 - physiology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Statistical analysis Testing Vero Cells Viral diseases Viral infections Virus Attachment - drug effects Virus Internalization - drug effects Viruses
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