A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies elicited by earlier viral isolates. Here we compare the specificities of p...

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Veröffentlicht in:	PLoS pathogens 2022-02, Vol.18 (2), p.e1010248
Hauptverfasser:	Greaney, Allison J, Starr, Tyler N, Eguia, Rachel T, Loes, Andrea N, Khan, Khadija, Karim, Farina, Cele, Sandile, Bowen, John E, Logue, Jennifer K, Corti, Davide, Veesler, David, Chu, Helen Y, Sigal, Alex, Bloom, Jesse D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation - immunology Antibody response Biology and Life Sciences Comparative analysis COVID-19 - immunology COVID-19 Drug Treatment Epitopes Epitopes - immunology Experiments Gene mutations Hierarchies Humans Immunization, Passive - methods Immunodominance Infections Libraries Medicine and Health Sciences Mutation Neutralization Neutralization Tests Plasma Polyclonal antibodies Research and Analysis Methods SARS-CoV-2 - genetics SARS-CoV-2 - immunology SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism Vaccines Viral diseases Viruses Yeast
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