Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice

Helminth neuroinfections represent serious medical conditions, but the diversity of the host-parasite interplay within the nervous tissue often remains poorly understood, partially due to the lack of laboratory models. Here, we investigated the neuroinvasion of the mouse spinal cord by Trichobilharz...

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Veröffentlicht in:	PLoS pathogens 2022-02, Vol.18 (2), p.e1010302
Hauptverfasser:	Macháček, Tomáš, Leontovyč, Roman, Šmídová, Barbora, Majer, Martin, Vondráček, Oldřich, Vojtěchová, Iveta, Petrásek, Tomáš, Horák, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Arginase Arginase - metabolism Behavior Biology and Life Sciences Biomarkers - metabolism Blood-brain barrier Care and treatment Chemokines - metabolism Chitinase Complications Complications and side effects Demyelination Deoxyribonucleic acid Diagnosis Disease Models, Animal Disruption DNA DNA fragmentation Eosinophils - metabolism Female Flow cytometry Gene Expression Profiling Glial cells Helminthiasis Host-Parasite Interactions Host-parasite relationships Immune response Immune system Immunity Infections Inflammation Invasiveness Leukocyte migration Leukocytes (eosinophilic) Localization Locomotion Major Histocompatibility Complex Medicine and Health Sciences Mice Mice, Inbred C57BL Nervous system diseases Nervous tissues Neuroglia - parasitology Neuronal-glial interactions Neurons - parasitology Parasites Pathology Reproducibility Risk factors Schistosomatidae Schistosomatidae - immunology Short term memory Spinal cord Spinal Cord - parasitology Transcriptomics Trematode Infections - immunology Trematode Infections - metabolism Trematode Infections - pathology Trichobilharzia regenti
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