Serum albumin and FT3/FT4 ratio as additional co-morbidity parameters to predict mortality as a new approach: The Haseki Scoring Index (updated Charlson Comorbidity Index)
Charlson Comorbidity Index (CCI) is the common and valid method to predict mortality by classifying comorbidities such as cardiovascular, metabolic, renal, hepatic, pulmonary diseases, and malignancy. Novel risk factors are not included in the Charlson Comorbidity Index, such as thyroid hormone inde...
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| Veröffentlicht in: | PloS one 2022-03, Vol.17 (3), p.e0264724 |
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| description | Charlson Comorbidity Index (CCI) is the common and valid method to predict mortality by classifying comorbidities such as cardiovascular, metabolic, renal, hepatic, pulmonary diseases, and malignancy. Novel risk factors are not included in the Charlson Comorbidity Index, such as thyroid hormone index (FT3/FT4 ratio) and serum albumin levels. In the present study, we aimed to assess whether the thyroid hormone index and albumin are useful clinical parameters in short and long-term mortality.
In the retrospective cohort study with a 5 year follow up, the data of 1292 patients who were hospitalized between January 1st-June 30th of 2014 were examined. Three months mortality as short term and 5-year mortality as long term were evaluated.
Three months and 5 years mortality rates for 1064 patients were analyzed. We showed that hypoalbuminemia and thyroid hormone index had statistically significant effects on short and long-term mortality. According to ROC analysis it was demonstrated that the scoring system including biochemical parameters such as thyroid hormone index and serum albumin level was more significant for 3-month mortality. In addition, both scoring systems are equal in demonstrating long-term mortality.
Thyroid hormone index and albumin could improve the prognostic performance of the original Charlson Comorbidity Index in short term mortality. The combined score may offer improvements in comorbidity summarization over existing scores. |
| doi_str_mv | 10.1371/journal.pone.0264724 |
| format | Article |
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In the retrospective cohort study with a 5 year follow up, the data of 1292 patients who were hospitalized between January 1st-June 30th of 2014 were examined. Three months mortality as short term and 5-year mortality as long term were evaluated.
Three months and 5 years mortality rates for 1064 patients were analyzed. We showed that hypoalbuminemia and thyroid hormone index had statistically significant effects on short and long-term mortality. According to ROC analysis it was demonstrated that the scoring system including biochemical parameters such as thyroid hormone index and serum albumin level was more significant for 3-month mortality. In addition, both scoring systems are equal in demonstrating long-term mortality.
Thyroid hormone index and albumin could improve the prognostic performance of the original Charlson Comorbidity Index in short term mortality. The combined score may offer improvements in comorbidity summarization over existing scores.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0264724</identifier><identifier>PMID: 35286325</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Albumin ; Biology and Life Sciences ; Care and treatment ; Cerebrovascular disease ; Chronic illnesses ; Chronic obstructive pulmonary disease ; Comorbidity ; Connective tissue ; Dementia ; Diabetes ; Diagnosis ; Health aspects ; Health risk assessment ; Health sciences ; Heart failure ; Hospital patients ; Hospitalization ; Hospitals ; Humans ; Immune system ; Internal medicine ; Kidney diseases ; Liver diseases ; Lung diseases ; Malignancy ; Measurement ; Medicine ; Medicine and Health Sciences ; Metabolism ; Methods ; Morbidity ; Mortality ; Parameters ; Patients ; Prognosis ; Retrospective Studies ; Risk analysis ; Risk factors ; Serum Albumin ; Statistical analysis ; Thyroid ; Thyroid gland ; Thyroid Hormones ; Ulcers</subject><ispartof>PloS one, 2022-03, Vol.17 (3), p.e0264724</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Cavusoglu Turker et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Cavusoglu Turker et al 2022 Cavusoglu Turker et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6074-d34c7e07c82ae61401f354cb717352aa64b26fda2e73432041864b146d871093</citedby><cites>FETCH-LOGICAL-c6074-d34c7e07c82ae61401f354cb717352aa64b26fda2e73432041864b146d871093</cites><orcidid>0000-0002-8041-1904 ; 0000-0002-6559-2575 ; 0000-0003-4232-7362</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920220/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920220/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35286325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavusoglu Turker, Betul</creatorcontrib><creatorcontrib>Turker, Fatih</creatorcontrib><creatorcontrib>Ahbab, Suleyman</creatorcontrib><creatorcontrib>Hoca, Emre</creatorcontrib><creatorcontrib>Tahmaz, Meryem</creatorcontrib><creatorcontrib>Ataoğlu, Hayriye Esra</creatorcontrib><title>Serum albumin and FT3/FT4 ratio as additional co-morbidity parameters to predict mortality as a new approach: The Haseki Scoring Index (updated Charlson Comorbidity Index)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Charlson Comorbidity Index (CCI) is the common and valid method to predict mortality by classifying comorbidities such as cardiovascular, metabolic, renal, hepatic, pulmonary diseases, and malignancy. Novel risk factors are not included in the Charlson Comorbidity Index, such as thyroid hormone index (FT3/FT4 ratio) and serum albumin levels. In the present study, we aimed to assess whether the thyroid hormone index and albumin are useful clinical parameters in short and long-term mortality.
In the retrospective cohort study with a 5 year follow up, the data of 1292 patients who were hospitalized between January 1st-June 30th of 2014 were examined. Three months mortality as short term and 5-year mortality as long term were evaluated.
Three months and 5 years mortality rates for 1064 patients were analyzed. We showed that hypoalbuminemia and thyroid hormone index had statistically significant effects on short and long-term mortality. According to ROC analysis it was demonstrated that the scoring system including biochemical parameters such as thyroid hormone index and serum albumin level was more significant for 3-month mortality. In addition, both scoring systems are equal in demonstrating long-term mortality.
Thyroid hormone index and albumin could improve the prognostic performance of the original Charlson Comorbidity Index in short term mortality. The combined score may offer improvements in comorbidity summarization over existing scores.</description><subject>Albumin</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Cerebrovascular disease</subject><subject>Chronic illnesses</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Comorbidity</subject><subject>Connective tissue</subject><subject>Dementia</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health sciences</subject><subject>Heart failure</subject><subject>Hospital patients</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immune system</subject><subject>Internal medicine</subject><subject>Kidney diseases</subject><subject>Liver diseases</subject><subject>Lung 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavusoglu Turker, Betul</au><au>Turker, Fatih</au><au>Ahbab, Suleyman</au><au>Hoca, Emre</au><au>Tahmaz, Meryem</au><au>Ataoğlu, Hayriye Esra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum albumin and FT3/FT4 ratio as additional co-morbidity parameters to predict mortality as a new approach: The Haseki Scoring Index (updated Charlson Comorbidity Index)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-03-14</date><risdate>2022</risdate><volume>17</volume><issue>3</issue><spage>e0264724</spage><pages>e0264724-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Charlson Comorbidity Index (CCI) is the common and valid method to predict mortality by classifying comorbidities such as cardiovascular, metabolic, renal, hepatic, pulmonary diseases, and malignancy. Novel risk factors are not included in the Charlson Comorbidity Index, such as thyroid hormone index (FT3/FT4 ratio) and serum albumin levels. In the present study, we aimed to assess whether the thyroid hormone index and albumin are useful clinical parameters in short and long-term mortality.
In the retrospective cohort study with a 5 year follow up, the data of 1292 patients who were hospitalized between January 1st-June 30th of 2014 were examined. Three months mortality as short term and 5-year mortality as long term were evaluated.
Three months and 5 years mortality rates for 1064 patients were analyzed. We showed that hypoalbuminemia and thyroid hormone index had statistically significant effects on short and long-term mortality. According to ROC analysis it was demonstrated that the scoring system including biochemical parameters such as thyroid hormone index and serum albumin level was more significant for 3-month mortality. In addition, both scoring systems are equal in demonstrating long-term mortality.
Thyroid hormone index and albumin could improve the prognostic performance of the original Charlson Comorbidity Index in short term mortality. The combined score may offer improvements in comorbidity summarization over existing scores.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35286325</pmid><doi>10.1371/journal.pone.0264724</doi><tpages>e0264724</tpages><orcidid>https://orcid.org/0000-0002-8041-1904</orcidid><orcidid>https://orcid.org/0000-0002-6559-2575</orcidid><orcidid>https://orcid.org/0000-0003-4232-7362</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-03, Vol.17 (3), p.e0264724 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2638937464 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Albumin Biology and Life Sciences Care and treatment Cerebrovascular disease Chronic illnesses Chronic obstructive pulmonary disease Comorbidity Connective tissue Dementia Diabetes Diagnosis Health aspects Health risk assessment Health sciences Heart failure Hospital patients Hospitalization Hospitals Humans Immune system Internal medicine Kidney diseases Liver diseases Lung diseases Malignancy Measurement Medicine Medicine and Health Sciences Metabolism Methods Morbidity Mortality Parameters Patients Prognosis Retrospective Studies Risk analysis Risk factors Serum Albumin Statistical analysis Thyroid Thyroid gland Thyroid Hormones Ulcers |
| title | Serum albumin and FT3/FT4 ratio as additional co-morbidity parameters to predict mortality as a new approach: The Haseki Scoring Index (updated Charlson Comorbidity Index) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T03%3A00%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20albumin%20and%20FT3/FT4%20ratio%20as%20additional%20co-morbidity%20parameters%20to%20predict%20mortality%20as%20a%20new%20approach:%20The%20Haseki%20Scoring%20Index%20(updated%20Charlson%20Comorbidity%20Index)&rft.jtitle=PloS%20one&rft.au=Cavusoglu%20Turker,%20Betul&rft.date=2022-03-14&rft.volume=17&rft.issue=3&rft.spage=e0264724&rft.pages=e0264724-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0264724&rft_dat=%3Cgale_plos_%3EA696721599%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2638937464&rft_id=info:pmid/35286325&rft_galeid=A696721599&rft_doaj_id=oai_doaj_org_article_2fc8be19a34b400b9554b1239cb0579d&rfr_iscdi=true |