Impact of maternal intermittent fasting during pregnancy on cardiovascular, metabolic and renal function in adult rat offspring
Pregnant Muslim women are exempt from fasting during Ramadan; however a majority are reported to fast. The impact of this form of maternal intermittent fasting (IF) on fetal development and offspring health is not well defined. Using a rat model, we have shown previously that maternal IF results in...
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| description | Pregnant Muslim women are exempt from fasting during Ramadan; however a majority are reported to fast. The impact of this form of maternal intermittent fasting (IF) on fetal development and offspring health is not well defined. Using a rat model, we have shown previously that maternal IF results in fetal growth restriction accompanied by changes in placental nutrient transport function. The aim of this study was to assess cardiovascular, metabolic and renal function in adult offspring of IF-exposed dams. Food was withheld from Wistar rats from 17:00 to 09:00 daily throughout pregnancy; controls had ad libitum access to food. Birth weight was unaffected; however male IF pups grew more slowly up to 10 weeks of age (P < 0.01) whereas IF females matched their control counterparts. Systolic blood pressure (SBP), glucose tolerance and basal renal function at 14 weeks were not affected by IF exposure. When offered saline solutions (0.9-2.1%) to drink, females showed a greater salt preference than males (P < 0.01); however there were no differences between dietary groups. A separate group of pups was weaned onto a 4% NaCl diet. SBP increased in IF pups sooner, at 7 weeks (P < 0.01), than controls which became hypertensive from 10 weeks. Renal function did not appear to differ; however markers of renal injury were elevated in IF males (P < 0.05). Maternal IF does not affect resting cardiovascular, metabolic and renal function; but when challenged by dietary salt load male IF offspring are more prone to renal injury. |
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The impact of this form of maternal intermittent fasting (IF) on fetal development and offspring health is not well defined. Using a rat model, we have shown previously that maternal IF results in fetal growth restriction accompanied by changes in placental nutrient transport function. The aim of this study was to assess cardiovascular, metabolic and renal function in adult offspring of IF-exposed dams. Food was withheld from Wistar rats from 17:00 to 09:00 daily throughout pregnancy; controls had ad libitum access to food. Birth weight was unaffected; however male IF pups grew more slowly up to 10 weeks of age (P < 0.01) whereas IF females matched their control counterparts. Systolic blood pressure (SBP), glucose tolerance and basal renal function at 14 weeks were not affected by IF exposure. When offered saline solutions (0.9-2.1%) to drink, females showed a greater salt preference than males (P < 0.01); however there were no differences between dietary groups. A separate group of pups was weaned onto a 4% NaCl diet. SBP increased in IF pups sooner, at 7 weeks (P < 0.01), than controls which became hypertensive from 10 weeks. Renal function did not appear to differ; however markers of renal injury were elevated in IF males (P < 0.05). Maternal IF does not affect resting cardiovascular, metabolic and renal function; but when challenged by dietary salt load male IF offspring are more prone to renal injury.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0258372</identifier><identifier>PMID: 35271586</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Access control ; Adult Children ; Amino acids ; Animal models ; Animals ; Biology and Life Sciences ; Birth weight ; Blood pressure ; Cardiovascular disease ; Developmental biology ; Diabetes ; Diet ; Ethics ; Fasting ; Female ; Females ; Fetus ; Fetuses ; Food ; Gender differences ; Glucose tolerance ; Growth ; Health aspects ; Humans ; Juveniles ; Kidney - physiology ; Male ; Males ; Medical research ; Medicine ; Medicine and Health Sciences ; Metabolism ; Metabolites ; Nutrient transport ; Nutrition research ; Offspring ; Physical Sciences ; Placenta - metabolism ; Pregnancy ; Pregnant women ; Prenatal Exposure Delayed Effects - metabolism ; Rats ; Rats, Wistar ; Renal function ; Saline solutions ; Sodium chloride ; Sodium Chloride, Dietary - metabolism ; Womens health</subject><ispartof>PloS one, 2022-03, Vol.17 (3), p.e0258372-e0258372</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Alkhalefah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The impact of this form of maternal intermittent fasting (IF) on fetal development and offspring health is not well defined. Using a rat model, we have shown previously that maternal IF results in fetal growth restriction accompanied by changes in placental nutrient transport function. The aim of this study was to assess cardiovascular, metabolic and renal function in adult offspring of IF-exposed dams. Food was withheld from Wistar rats from 17:00 to 09:00 daily throughout pregnancy; controls had ad libitum access to food. Birth weight was unaffected; however male IF pups grew more slowly up to 10 weeks of age (P < 0.01) whereas IF females matched their control counterparts. Systolic blood pressure (SBP), glucose tolerance and basal renal function at 14 weeks were not affected by IF exposure. When offered saline solutions (0.9-2.1%) to drink, females showed a greater salt preference than males (P < 0.01); however there were no differences between dietary groups. A separate group of pups was weaned onto a 4% NaCl diet. SBP increased in IF pups sooner, at 7 weeks (P < 0.01), than controls which became hypertensive from 10 weeks. Renal function did not appear to differ; however markers of renal injury were elevated in IF males (P < 0.05). Maternal IF does not affect resting cardiovascular, metabolic and renal function; but when challenged by dietary salt load male IF offspring are more prone to renal injury.</description><subject>Access control</subject><subject>Adult Children</subject><subject>Amino acids</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Developmental biology</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Ethics</subject><subject>Fasting</subject><subject>Female</subject><subject>Females</subject><subject>Fetus</subject><subject>Fetuses</subject><subject>Food</subject><subject>Gender differences</subject><subject>Glucose tolerance</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Juveniles</subject><subject>Kidney - physiology</subject><subject>Male</subject><subject>Males</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Nutrient transport</subject><subject>Nutrition research</subject><subject>Offspring</subject><subject>Physical Sciences</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal function</subject><subject>Saline solutions</subject><subject>Sodium chloride</subject><subject>Sodium Chloride, Dietary - metabolism</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgig4Yz7aNL0RlsWPgYUFv27DaZp0srTJbJIu7pV_3dTpLlPZC8lFQvKc9-S8ycmy5xitMa3w-0s3egv9euesWiNSclqRB9kxrilZMYLow4P1UfYkhEuESsoZe5wd0ZJUuOTsOPu9GXYgY-50PkBUk2JubFoMJkZlY64hRGO7vB39NO286ixYeZM7m0vwrXHXEOTYg3-XDypC43ojc7Bt7tUkpkcro0mwsTm0Yx9zD1M6HXaT4NPskYY-qGfzfJL9-PTx-9mX1fnF583Z6flKsprEVYE1YF5BVWnMZKGapsQkVdHwuqSSUQact6htCsWllmXNy6rgyZS6AK1QUdCT7OVed9e7IGbvgiCMcoQQLupEbPZE6-BSpMsN4G-EAyP-bjjfCfDRyF4JrBVuW85JhVCBmppDA7QtCKtAY41Y0vowZxubQbUyGemhX4guT6zZis5dC15jgglPAm9mAe-uRhWiGEyQqu_BKjfu710RVBY0oa_-Qe-vbqY6SAUYq13KKydRccpqRimt60lrfQ-VRqsGI9NH0ybtLwLeLgISE9Wv2MEYgth8-_r_7MXPJfv6gN0q6OM2uH6cflJYgsUelN6F4JW-MxkjMfXJrRti6hMx90kKe3H4QHdBt41B_wBYkA79</recordid><startdate>20220310</startdate><enddate>20220310</enddate><creator>Alkhalefah, Alaa</creator><creator>Eyre, Heather J</creator><creator>Hussain, Rezwana</creator><creator>Glazier, Jocelyn D</creator><creator>Ashton, Nick</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3366-1617</orcidid></search><sort><creationdate>20220310</creationdate><title>Impact of maternal intermittent fasting during pregnancy on cardiovascular, metabolic and renal function in adult rat offspring</title><author>Alkhalefah, Alaa ; Eyre, Heather J ; Hussain, Rezwana ; Glazier, Jocelyn D ; Ashton, Nick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-41fa187a77f16c4ebb512352b8953c636a88d0db4e8cfc598574802594afe0443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Access control</topic><topic>Adult Children</topic><topic>Amino acids</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Developmental biology</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Ethics</topic><topic>Fasting</topic><topic>Female</topic><topic>Females</topic><topic>Fetus</topic><topic>Fetuses</topic><topic>Food</topic><topic>Gender differences</topic><topic>Glucose tolerance</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Juveniles</topic><topic>Kidney - 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The impact of this form of maternal intermittent fasting (IF) on fetal development and offspring health is not well defined. Using a rat model, we have shown previously that maternal IF results in fetal growth restriction accompanied by changes in placental nutrient transport function. The aim of this study was to assess cardiovascular, metabolic and renal function in adult offspring of IF-exposed dams. Food was withheld from Wistar rats from 17:00 to 09:00 daily throughout pregnancy; controls had ad libitum access to food. Birth weight was unaffected; however male IF pups grew more slowly up to 10 weeks of age (P < 0.01) whereas IF females matched their control counterparts. Systolic blood pressure (SBP), glucose tolerance and basal renal function at 14 weeks were not affected by IF exposure. When offered saline solutions (0.9-2.1%) to drink, females showed a greater salt preference than males (P < 0.01); however there were no differences between dietary groups. A separate group of pups was weaned onto a 4% NaCl diet. SBP increased in IF pups sooner, at 7 weeks (P < 0.01), than controls which became hypertensive from 10 weeks. Renal function did not appear to differ; however markers of renal injury were elevated in IF males (P < 0.05). Maternal IF does not affect resting cardiovascular, metabolic and renal function; but when challenged by dietary salt load male IF offspring are more prone to renal injury.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35271586</pmid><doi>10.1371/journal.pone.0258372</doi><tpages>e0258372</tpages><orcidid>https://orcid.org/0000-0003-3366-1617</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Access control Adult Children Amino acids Animal models Animals Biology and Life Sciences Birth weight Blood pressure Cardiovascular disease Developmental biology Diabetes Diet Ethics Fasting Female Females Fetus Fetuses Food Gender differences Glucose tolerance Growth Health aspects Humans Juveniles Kidney - physiology Male Males Medical research Medicine Medicine and Health Sciences Metabolism Metabolites Nutrient transport Nutrition research Offspring Physical Sciences Placenta - metabolism Pregnancy Pregnant women Prenatal Exposure Delayed Effects - metabolism Rats Rats, Wistar Renal function Saline solutions Sodium chloride Sodium Chloride, Dietary - metabolism Womens health |
| title | Impact of maternal intermittent fasting during pregnancy on cardiovascular, metabolic and renal function in adult rat offspring |
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