Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress

In the present study, we evaluate the effect of acute restraint stress (15 min) of male Wistar rats on social interaction measurements and c-Fos immunoreactivity (c-Fos-ir) expression, a marker of neuronal activity, in areas involved with the modulation of acute physical restraint in rats, i.e., the...

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Veröffentlicht in:	PloS one 2022-03, Vol.17 (3), p.e0262728
Hauptverfasser:	de Oliveira, Rodolpho Pereira, de Andrade, José Simões, Spina, Marianna, Chamon, João Vítor, Silva, Paulo Henrique Dias, Werder, Ana Keyla, Ortolani, Daniela, Thomaz, Lucas de Santana Cardoso, Romariz, Simone, Ribeiro, Daniel Araki, Longo, Beatriz Monteiro, Spadari, Regina Célia, Viana, Milena de Barros, Melo-Thomas, Liana, Céspedes, Isabel Cristina, da Silva, Regina Cláudia Barbosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute stress disorder Amygdala Animals Antipsychotic Agents - pharmacology Antipsychotics Behavior Biology and Life Sciences Blocking Brain Brain - drug effects Brain - metabolism c-Fos protein Cerebral cortex Clozapine Clozapine - pharmacology Constraints Cortex (cingulate) Dosage and administration Drug therapy Experiments Forebrain Hippocampus Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Hypothalamus Hypotheses Immunoreactivity Male Medicine and Health Sciences Nucleus accumbens Paraventricular nucleus Physical restraints Physiology Pituitary Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Prefrontal cortex Pretreatment Proto-Oncogene Proteins c-fos - metabolism Psychotropic drugs Raphe nuclei Rats Rats, Wistar Regions Research and Analysis Methods Restraint, Physical Septum Social behavior in animals Social factors Social interaction Social Interaction - drug effects Social interactions Social research Social Sciences Stress Stress response Stress, Psychological - metabolism
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