Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease
Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains amb...
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| creator | Valkonen, Kati Mäkelä, Jyrki P Airaksinen, Katja Nurminen, Jussi Kivisaari, Riku Renvall, Hanna Pekkonen, Eero |
| description | Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS. |
| doi_str_mv | 10.1371/journal.pone.0264333 |
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Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0264333</identifier><identifier>PMID: 35202426</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Auditory pathways ; Auditory Perception ; Brain ; Brain stimulation ; Care and treatment ; Deep Brain Stimulation ; Ears & hearing ; Electrical stimuli ; Evoked Potentials, Auditory ; Female ; Follow-Up Studies ; Health aspects ; Hearing ; Hearing loss ; Humans ; Information processing ; Laboratories ; Latency ; Magnetoencephalography ; Male ; Medical imaging ; Middle Aged ; Movement disorders ; Neural networks ; Neural plasticity ; Neurodegenerative diseases ; Neurology ; Neuroplasticity ; Neurosciences ; Parkinson Disease - therapy ; Parkinson's disease ; Patients ; Solitary tract nucleus ; Stimulation ; Subthalamic Nucleus ; Surveys and Questionnaires ; Testing ; Thalamus</subject><ispartof>PloS one, 2022-02, Vol.17 (2), p.e0264333-e0264333</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Valkonen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35202426</pmid><doi>10.1371/journal.pone.0264333</doi><tpages>e0264333</tpages><orcidid>https://orcid.org/0000-0003-1621-8752</orcidid><orcidid>https://orcid.org/0000-0001-7589-7826</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Auditory pathways Auditory Perception Brain Brain stimulation Care and treatment Deep Brain Stimulation Ears & hearing Electrical stimuli Evoked Potentials, Auditory Female Follow-Up Studies Health aspects Hearing Hearing loss Humans Information processing Laboratories Latency Magnetoencephalography Male Medical imaging Middle Aged Movement disorders Neural networks Neural plasticity Neurodegenerative diseases Neurology Neuroplasticity Neurosciences Parkinson Disease - therapy Parkinson's disease Patients Solitary tract nucleus Stimulation Subthalamic Nucleus Surveys and Questionnaires Testing Thalamus |
| title | Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease |
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