Insights into POT1 structural dynamics revealed by cryo-EM

Telomeres are protein-DNA complexes that protect the ends of linear eukaryotic chromosomes. Mammalian telomeric DNA consists of 5'-(TTAGGG)n-3' double-stranded repeats, followed by up to several hundred bases of a 3' single-stranded G-rich overhang. The G-rich overhang is bound by the...

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Veröffentlicht in:	PloS one 2022-02, Vol.17 (2), p.e0264073-e0264073
Hauptverfasser:	Smith, Emmanuel W, Lattmann, Simon, Liu, Zhehui Barry, Ahsan, Bilal, Rhodes, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Analysis Binding Sites Biology and Life Sciences Cell division Chromosomes Cloning Cryoelectron Microscopy - methods Crystal structure Crystals Deoxyribonucleic acid DNA DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Humans Kinases Laboratories Ligands Medical research Molecular biology Nucleic Acid Conformation Nucleotides Physical Sciences Plasmids Protein Binding Protein Conformation Protein structure Proteins Research and Analysis Methods Shelterin Complex - chemistry Shelterin Complex - genetics Shelterin Complex - metabolism Structure Telomerase Telomere - genetics Telomere-Binding Proteins - chemistry Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism Telomeres Tripeptidyl-Peptidase 1 - chemistry Tripeptidyl-Peptidase 1 - genetics Tripeptidyl-Peptidase 1 - metabolism
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