Selective neurodegeneration of the hippocampus caused by chronic cerebral hypoperfusion: F-18 FDG PET study in rats

Chronic cerebral hypoperfusion (CCH) is known to induce Alzheimer's disease (AD) pathology, but its mechanism remains unclear. The purpose of this study was to identify the cerebral regions that are affected by CCH, and to evaluate the development of AD pathology in a rat model of CCH. A rat mo...

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Veröffentlicht in:	PloS one 2022-02, Vol.17 (2), p.e0262224-e0262224
Hauptverfasser:	Lee, Jung-In, Lim, Ji Sun, Hong, Jeong-Ho, Kim, Shin, Lee, Sang-Woo, Ji, Hyun Dong, Won, Kyoung Sook, Song, Bong-Il, Kim, Hae Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyloid beta-Peptides - metabolism Analysis Animal cognition Animals Arteries Biology and Life Sciences Brain - diagnostic imaging Brain research Care and treatment Carotid arteries Carotid Arteries - surgery Carotid artery Cognitive ability Cortex (somatosensory) Dementia Diagnosis Disease Models, Animal Evaluation Fluorine isotopes Fluorodeoxyglucose F18 - chemistry Glucose Glucose - metabolism Hippocampus Hippocampus (Brain) Hippocampus - metabolism Hospitals Lasers Male Maze Learning Medicine and Health Sciences Metabolism Neurodegeneration Neurodegenerative diseases Nuclear medicine Pathology Peptide Fragments - metabolism Positron emission Positron emission tomography Radioisotopes Rats Rats, Wistar Regions Research and Analysis Methods Rodents Surgery Tau protein tau Proteins - metabolism Tomography Western blotting
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