Obesity at early adulthood increases risk of gastric cancer from the Health Examinees-Gem (HEXA-G) study
Emerging evidence has indicated a possible link between obesity in early life with subsequent cancer risks, but its association with gastric cancer remains unknown. This study aimed to investigate the association of obesity at ages 18-20 and 35 with the later risk of gastric cancer among the Korean...
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| creator | Lee, Hwi-Won Huang, Dan Shin, Woo-Kyoung de la Torre, Katherine Yang, Jae Jeong Song, Minkyo Shin, Aesun Lee, Jong-Koo Kang, Daehee |
| description | Emerging evidence has indicated a possible link between obesity in early life with subsequent cancer risks, but its association with gastric cancer remains unknown. This study aimed to investigate the association of obesity at ages 18-20 and 35 with the later risk of gastric cancer among the Korean population. Included were 122,724 individuals who participated in the large-scale prospective cohort study, the Health Examinees-Gem (HEXA-G) study, during 2004-2017. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for gastric cancer risk associated with body mass index (BMI) at ages 18-20 and 35 years. During a mean follow-up period of 8.6±2.1 years, a total 927 gastric cancer cases (531 men and 396 women) were identified. When compared to normal BMI (18.5-23.0 kg/m2), obesity (BMI ≥30 kg/m2) at age 35 was significantly associated with increased risk of gastric cancer later in life among total participants (HR 1.94, 95% CI 1.26-2.97, p 0.01). When analyzed separately by sex, obesity at 35 years of age was significantly associated with increased risk of gastric cancer among both men (HR 1.79, 95% CI 1.02-3.13, p 0.05) and women (HR 2.35, 95% CI 1.21-4.60, p 0.02). No significant associations were found for obesity at late adolescence in both men and women. Our findings suggest that obesity in early adulthood may be associated with an increased risk of gastric cancer. The results may aid in understanding the etiology of GC in a population with a divergent trend of gastric cancer. |
| doi_str_mv | 10.1371/journal.pone.0260826 |
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This study aimed to investigate the association of obesity at ages 18-20 and 35 with the later risk of gastric cancer among the Korean population. Included were 122,724 individuals who participated in the large-scale prospective cohort study, the Health Examinees-Gem (HEXA-G) study, during 2004-2017. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for gastric cancer risk associated with body mass index (BMI) at ages 18-20 and 35 years. During a mean follow-up period of 8.6±2.1 years, a total 927 gastric cancer cases (531 men and 396 women) were identified. When compared to normal BMI (18.5-23.0 kg/m2), obesity (BMI ≥30 kg/m2) at age 35 was significantly associated with increased risk of gastric cancer later in life among total participants (HR 1.94, 95% CI 1.26-2.97, p 0.01). When analyzed separately by sex, obesity at 35 years of age was significantly associated with increased risk of gastric cancer among both men (HR 1.79, 95% CI 1.02-3.13, p 0.05) and women (HR 2.35, 95% CI 1.21-4.60, p 0.02). No significant associations were found for obesity at late adolescence in both men and women. Our findings suggest that obesity in early adulthood may be associated with an increased risk of gastric cancer. The results may aid in understanding the etiology of GC in a population with a divergent trend of gastric cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0260826</identifier><identifier>PMID: 35120118</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Biology and Life Sciences ; Body mass ; Body Mass Index ; Body size ; Cancer ; Child development ; Cohort analysis ; Complications and side effects ; Confidence intervals ; Demographic aspects ; Etiology ; Family medical history ; Female ; Gastric cancer ; Health risks ; Humans ; Male ; Medical schools ; Medicine and Health Sciences ; Men ; Middle Aged ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Population ; Preventive medicine ; Proportional Hazards Models ; Prospective Studies ; Questionnaires ; Republic of Korea - epidemiology ; Research and Analysis Methods ; Risk ; Risk Factors ; Statistical models ; Stomach cancer ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - etiology ; University graduates ; Women ; Womens health ; Young Adult ; Young adults</subject><ispartof>PloS one, 2022-02, Vol.17 (2), p.e0260826</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The results may aid in understanding the etiology of GC in a population with a divergent trend of gastric cancer.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Cancer</subject><subject>Child development</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Demographic aspects</subject><subject>Etiology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Population</subject><subject>Preventive medicine</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>Republic of Korea - epidemiology</subject><subject>Research and Analysis Methods</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Statistical models</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - etiology</subject><subject>University graduates</subject><subject>Women</subject><subject>Womens health</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1vEzEQXSEQLYV_gMASl3LY4G_vXpCiKiSVKvUCEjfL8Y4Th911sHcR-fc4zbZqUeWDRzPvvfnQK4r3BM8IU-TLLoyxN-1sH3qYYSpxReWL4pzUjJaSYvbyUXxWvElph7FglZSvizMmCMWEVOfF9nYNyQ8HZAYEJrY5aMZ22IbQIN_bCCZBQtGnXyg4tDFpiN4ia3oLEbkYOjRsAa3AZA5a_DWd7wFSuYQOXa4WP-fl8jNKw9gc3havnGkTvJv-i-LHt8X3q1V5c7u8vprflFbUbCgNYxjM2mBwQpCKgmWWVIYax41SUq2xZQ7WQKXgjeBW1Y0irAZXgaslOHZRfDzp7tuQ9HSkpKmkQtBaUZoR1ydEE8xO76PvTDzoYLy-S4S40SYO3raghXJOuloJDhWvGlNzLhvJnVJYWCNl1vo6dRvXHTQW-iGa9ono00rvt3oT_uiqIqKWPAtcTgIx_B4hDbrzyULbmh7CeDe3xAQTVWXop_-gz283oTYmL-B7F3JfexTVc1mTiuOaH1GzZ1D5NdB5mx3lfM4_IfATwcaQUgT3sCPB-ujH-2H00Y968mOmfXh8nwfSvQHZP6ob3L8</recordid><startdate>20220204</startdate><enddate>20220204</enddate><creator>Lee, Hwi-Won</creator><creator>Huang, Dan</creator><creator>Shin, Woo-Kyoung</creator><creator>de la Torre, Katherine</creator><creator>Yang, Jae Jeong</creator><creator>Song, Minkyo</creator><creator>Shin, Aesun</creator><creator>Lee, Jong-Koo</creator><creator>Kang, Daehee</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9412-2871</orcidid><orcidid>https://orcid.org/0000-0003-4031-5878</orcidid></search><sort><creationdate>20220204</creationdate><title>Obesity at early adulthood increases risk of gastric cancer from the Health Examinees-Gem (HEXA-G) study</title><author>Lee, Hwi-Won ; Huang, Dan ; Shin, Woo-Kyoung ; de la Torre, Katherine ; Yang, Jae Jeong ; Song, Minkyo ; Shin, Aesun ; Lee, Jong-Koo ; Kang, Daehee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-a330eaba0ef55182ec3c18a2af4a7767b0c3febe2654d54c79d7139ef8ef96ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Cancer</topic><topic>Child development</topic><topic>Cohort analysis</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Demographic aspects</topic><topic>Etiology</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine and Health Sciences</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - 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This study aimed to investigate the association of obesity at ages 18-20 and 35 with the later risk of gastric cancer among the Korean population. Included were 122,724 individuals who participated in the large-scale prospective cohort study, the Health Examinees-Gem (HEXA-G) study, during 2004-2017. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for gastric cancer risk associated with body mass index (BMI) at ages 18-20 and 35 years. During a mean follow-up period of 8.6±2.1 years, a total 927 gastric cancer cases (531 men and 396 women) were identified. When compared to normal BMI (18.5-23.0 kg/m2), obesity (BMI ≥30 kg/m2) at age 35 was significantly associated with increased risk of gastric cancer later in life among total participants (HR 1.94, 95% CI 1.26-2.97, p 0.01). When analyzed separately by sex, obesity at 35 years of age was significantly associated with increased risk of gastric cancer among both men (HR 1.79, 95% CI 1.02-3.13, p 0.05) and women (HR 2.35, 95% CI 1.21-4.60, p 0.02). No significant associations were found for obesity at late adolescence in both men and women. Our findings suggest that obesity in early adulthood may be associated with an increased risk of gastric cancer. The results may aid in understanding the etiology of GC in a population with a divergent trend of gastric cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35120118</pmid><doi>10.1371/journal.pone.0260826</doi><orcidid>https://orcid.org/0000-0002-9412-2871</orcidid><orcidid>https://orcid.org/0000-0003-4031-5878</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2022-02, Vol.17 (2), p.e0260826 |
| issn | 1932-6203 1932-6203 |
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| recordid | cdi_plos_journals_2625529722 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Age Biology and Life Sciences Body mass Body Mass Index Body size Cancer Child development Cohort analysis Complications and side effects Confidence intervals Demographic aspects Etiology Family medical history Female Gastric cancer Health risks Humans Male Medical schools Medicine and Health Sciences Men Middle Aged Obesity Obesity - complications Obesity - epidemiology Population Preventive medicine Proportional Hazards Models Prospective Studies Questionnaires Republic of Korea - epidemiology Research and Analysis Methods Risk Risk Factors Statistical models Stomach cancer Stomach Neoplasms - epidemiology Stomach Neoplasms - etiology University graduates Women Womens health Young Adult Young adults |
| title | Obesity at early adulthood increases risk of gastric cancer from the Health Examinees-Gem (HEXA-G) study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T07%3A29%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obesity%20at%20early%20adulthood%20increases%20risk%20of%20gastric%20cancer%20from%20the%20Health%20Examinees-Gem%20(HEXA-G)%20study&rft.jtitle=PloS%20one&rft.au=Lee,%20Hwi-Won&rft.date=2022-02-04&rft.volume=17&rft.issue=2&rft.spage=e0260826&rft.pages=e0260826-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0260826&rft_dat=%3Cgale_plos_%3EA691840942%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2625529722&rft_id=info:pmid/35120118&rft_galeid=A691840942&rft_doaj_id=oai_doaj_org_article_57ff6f9754e848da9446d64f7705ca66&rfr_iscdi=true |