A novel dual-labeled small peptide as a multimodal imaging agent for targeting wild-type EGFR in tumors

The epidermal growth factor receptor (EGFR) is over-expressed in various human cancer. The over-expression of EGFR in tumors is an excellent target for the development of cancer imaging agents. In the present study, we developed Tc-99m SYPIPDT-GHEG-ECG-K-tetramethylrhodamine (SYPIPDT-ECG-TAMRA) as a...

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Veröffentlicht in:	PloS one 2022-02, Vol.17 (2), p.e0263474-e0263474
Hauptverfasser:	Kim, Myoung Hyoun, Kim, Seul-Gi, Kim, Dae-Weung
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animal models Animals Apoptosis Binding Biology and Life Sciences Cameras Cancer Care and treatment Cell Line, Tumor Chemical synthesis Chromatography Diagnosis Dosage EKG Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - metabolism Female Fluorescence Genetic aspects Growth factors Health aspects Homozygote Humans Imaging In vivo methods and tests Kinases Kinetics Lung cancer Medicine and Health Sciences Mice Mice, Inbred BALB C Microscopy, Confocal Molecular Imaging Monoclonal antibodies Multimodal Imaging - methods Muscles Neoplasm Transplantation Neoplasms - metabolism Nitrogen Nuclear medicine Overexpression Peptide synthesis Peptides Peptides - chemistry Peptides - pharmacology Protein Binding Radioisotopes Radiolabelling Radiopharmaceuticals - chemistry Research and Analysis Methods Rhodamines - pharmacology Solid phases Technetium - chemistry Tissue Distribution Tumor cells Tumors
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