Adrenal suppression in patients with chronic obstructive pulmonary disease treated with glucocorticoids: Role of specific glucocorticoid receptor polymorphisms

Single-nucleotide polymorphisms (SNPs) of the glucocorticoid receptor (GR) gene NR3C1 have been associated with an altered sensitivity to glucocorticoids, and thus may alter the therapeutic effects of glucocorticoids. We investigated the prevalence of adrenal suppression after treatment with glucoco...

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Veröffentlicht in:	PloS one 2022-02, Vol.17 (2), p.e0262898
Hauptverfasser:	Sivapalan, Pradeesh, Borresen, Stina Willemoes, Eklöf, Josefin, Klose, Marianne, Holm, Freja S, Feldt-Rasmussen, Ulla, Rossing, Maria, Jørgensen, Niklas R, Marvig, Rasmus L, Saeed, Mohamad Isam, Wilcke, Torgny, Seersholm, Niels, Mathioudakis, Alexander G, Vestbo, Jørgen, Jensen, Jens-Ulrik Stæhr
Format:	Artikel
Sprache:	eng
Schlagworte:	Addison's disease Adrenal Glands - drug effects Adrenal Glands - metabolism Aged Biology and Life Sciences Chronic obstructive pulmonary disease Clinical medicine Complications and side effects Corticoids Corticosteroids Diabetes Drug dosages Drug therapy Endocrinology Female Glucocorticoid receptors Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Haplotypes Health risks Health sciences Hormones Hospitals Humans Hydrocortisone - blood Lung diseases Male Medical treatment Medicine Medicine and Health Sciences Metabolic disorders Middle Aged Nucleotides Obstructive lung disease Patients Polymorphism Polymorphism, Single Nucleotide Prospective Studies Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - genetics Receptors Receptors, Glucocorticoid - genetics Rheumatoid arthritis Risk factors Single-nucleotide polymorphism Steroids
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