Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis

Sepsis is associated with high platelet turnover and elevated levels of immature platelets. Changes in the platelet transcriptome and the specific impact of immature platelets on the platelet transcriptome remain unclear. Thus, this study sought to address whether and how elevated levels of immature...

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Veröffentlicht in:	PloS one 2022-01, Vol.17 (1), p.e0260222-e0260222
Hauptverfasser:	Nührenberg, Thomas G, Stöckle, Jasmin, Marini, Federico, Zurek, Mark, Grüning, Björn A, Benes, Vladimir, Hein, Lutz, Neumann, Franz-Josef, Stratz, Christian, Cederqvist, Marco, Hochholzer, Willibald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine diphosphate Aged Base Sequence - genetics Biology and Life Sciences Blood platelets Blood Platelets - metabolism Blood Platelets - pathology Cardiovascular disease CD45 antigen Cell Fractionation - methods Circular RNA Clustering Complications and side effects Contamination Coronary artery Coronary artery disease Coronary vessels COVID-19 Data analysis Down-regulation Gene Expression - genetics Gene Expression Profiling - methods Gene regulation Gene sequencing Genes Genetic aspects Health aspects Heart diseases Humans Leukocytes Male Medical imaging Medicine and Health Sciences Next-generation sequencing Patients Physical Sciences Platelet Activation - genetics Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Platelet Count Platelet Function Tests Platelets Principal components analysis Proteins Research and analysis methods Ribonucleic acid RNA RNA sequencing RNA, Circular - analysis RNA, Circular - genetics Sepsis Sepsis - blood Sepsis - genetics Sequence Analysis, RNA - methods Statistical analysis Thrombin Transcriptome - genetics Transcriptomes Translation Vein & artery diseases
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