A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence

Type VII secretion systems (T7SS) have been identified in Actinobacteria and Firmicutes and have been shown to secrete effector proteins with functions in virulence, host toxicity, and/or interbacterial killing in a few genera. Bioinformatic analysis indicates that isolates of Group B Streptococcus...

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Veröffentlicht in:	PLoS pathogens 2021-12, Vol.17 (12), p.e1010121-e1010121
Hauptverfasser:	Spencer, Brady L, Tak, Uday, Mendonça, Jéssica C, Nagao, Prescilla E, Niederweis, Michael, Doran, Kelly S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animal models Animals Bacteria Bacterial proteins Bacterial Proteins - metabolism Biology and Life Sciences Brain Cell-mediated cytotoxicity Cells, Cultured Chemical properties Cytotoxicity Endothelium Genes Genetic engineering Genomes Gram-positive bacteria Homology Host-bacteria relationships Humans Identification and classification Medicine and Health Sciences Meningitis Mice Pathogenesis Pathogens Phenotypes Pore formation Proteins Research and Analysis Methods Secretion Streptococcal Infections - metabolism Streptococcus Streptococcus agalactiae Streptococcus agalactiae - metabolism Streptococcus agalactiae - pathogenicity Streptococcus infections Toxicity Type VII Secretion Systems - metabolism Virulence Virulence (Microbiology) Virulence - physiology
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