Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

Regulatory T (Treg) cells, which constitute about 5-10% of CD4+T cells expressing Foxp3 transcription factor and CD25(IL-2 receptor α chain), are key regulators in controlling immunological self-tolerance and various immune responses. However, how Treg cells control antigen-specific immunity to seve...

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Veröffentlicht in:	PLoS pathogens 2021-12, Vol.17 (12), p.e1010085-e1010085
Hauptverfasser:	Uraki, Ryuta, Imai, Masaki, Ito, Mutsumi, Shime, Hiroaki, Odanaka, Mizuyu, Okuda, Moe, Kawaoka, Yoshihiro, Yamazaki, Sayuri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adaptive Immunity - immunology Adjuvants Animals Antibodies Antigen presentation Antigen Presentation - immunology Antigens Antigens, Viral - immunology Autoimmune diseases Biology and life sciences CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell-mediated immunity Chlorocebus aethiops Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - virology Dendritic cells Dendritic Cells - immunology Depletion Experiments Female Forkhead Transcription Factors - immunology Foxp3 protein Germinal Center - immunology Humans Humoral immunity Immune Tolerance Immunity Immunity (cell-mediated) Immunological tolerance Immunology Immunoregulation Interferon Interleukin 2 Interleukin 2 receptors Lymph nodes Lymphatic system Lymphocytes Lymphocytes T Maturation Medicine and health sciences Mice Mice, Inbred C57BL Mice, Inbred MRL lpr Proteins Research and Analysis Methods Rodents SARS-CoV-2 - immunology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein T-Lymphocytes, Regulatory - immunology Vaccines Vero Cells γ-Interferon
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