Poststroke dendritic arbor regrowth requires the actin nucleator Cobl

Ischemic stroke is a major cause of death and long-term disability. We demonstrate that middle cerebral artery occlusion (MCAO) in mice leads to a strong decline in dendritic arborization of penumbral neurons. These defects were subsequently repaired by an ipsilateral recovery process requiring the...

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Veröffentlicht in:	PLoS biology 2021-12, Vol.19 (12), p.e3001399-e3001399
Hauptverfasser:	Ji, Yuanyuan, Koch, Dennis, González Delgado, Jule, Günther, Madlen, Witte, Otto W, Kessels, Michael M, Frahm, Christiane, Qualmann, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Actins - metabolism Analysis Animals Biology and Life Sciences Brain Calpain Cerebral blood flow Cortex (motor) Cytoskeletal Proteins - metabolism Dendritic branching Dendritic cells Dendritic structure Excitotoxicity Gene expression Gene Expression - genetics Genetic aspects Identification and classification Infarction, Middle Cerebral Artery Ischemia Ischemic Stroke - metabolism Male Medicine and Health Sciences Messenger RNA Mice Mice, Inbred C57BL Mice, Knockout Microfilament Proteins - genetics Microfilament Proteins - metabolism Microfilament Proteins - physiology Molecular modelling Neuronal Plasticity - physiology Neurons Neurons - metabolism Neurons - physiology Occlusion Properties Proteins Proteolysis Recovery Regrowth Repair Research and Analysis Methods Stroke Stroke (Disease)
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