A framework for mutational signature analysis based on DNA shape parameters

The mutation risk of a DNA locus depends on its oligonucleotide context. In turn, mutability of oligonucleotides varies across individuals, due to exposure to mutagenic agents or due to variable efficiency and/or accuracy of DNA repair. Such variability is captured by mutational signatures, a mathem...

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Veröffentlicht in:	PloS one 2022-01, Vol.17 (1), p.e0262495
Hauptverfasser:	Karolak, Aleksandra, Levatić, Jurica, Supek, Fran
Format:	Artikel
Sprache:	eng
Schlagworte:	APOBEC Deaminases - metabolism Auroral kilometric radiation Biology and Life Sciences Cancer Conformation Cytosine Cytosine deaminase Data science Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA Damage DNA Mutational Analysis - methods DNA Repair Exposure Feature extraction Frequency spectrum Gene mutations Genome, Human Genomes Grooves Health aspects Human tissues Humans Mathematical analysis Medicine and Health Sciences Molecular structure Mutagenesis Mutagens Mutation Mutation rates Negative selection Neoplasms - genetics Neoplasms - pathology Nucleic Acid Conformation Nucleotide sequence Oligonucleotides Parameters Physiological aspects Radiation Repair Sequences Signature analysis Signatures Structure Transcriptome Tumors Variability
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