Mercury is present in neurons and oligodendrocytes in regions of the brain affected by Parkinson's disease and co-localises with Lewy bodies

Environmental toxicants are suspected to play a part in the pathogenesis of idiopathic Parkinson's disease (PD) and may underlie its increasing incidence. Mercury exposure in humans is common and is increasing due to accelerating levels of atmospheric mercury, and mercury damages cells via oxid...

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Veröffentlicht in:	PloS one 2022-01, Vol.17 (1), p.e0262464-e0262464
Hauptverfasser:	Pamphlett, Roger, Bishop, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer's disease Atmospheric composition Atmospheric mercury Autoimmunity Autopsies Axons Biology and Life Sciences Brain Brain - metabolism Brain - pathology Brain research Burning Case-Control Studies Cell membranes Cerebellum Contaminants Cortex (motor) Damage Development and progression Environmental aspects Exposure Female Fossil fuels Glial cells Health aspects Heavy metals Humans Inductively coupled plasma mass spectrometry Laser ablation Lasers Lewy bodies Lewy Bodies - metabolism Lewy Bodies - pathology Loci Locus Coeruleus - metabolism Locus Coeruleus - pathology Male Mass spectrometry Mass spectroscopy Medicine and Health Sciences Mercury Mercury (metal) Mercury - analysis Mercury - metabolism Middle Aged Movement disorders Multiple sclerosis Neostriatum Neurodegenerative diseases Neuronal-glial interactions Neurons Neurons - metabolism Neurons - pathology Oligodendrocytes Oligodendroglia Oligodendroglia - metabolism Oligodendroglia - pathology Organs Oxidative stress Paraffin Paraffins Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Pathogenesis Physical Sciences Physiological aspects Prognosis Retrospective Studies Rigidity Risk factors Silver Substantia alba Substantia grisea Synuclein Thalamus Toxicants
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