Vitronectin-derived bioactive peptide prevents spondyloarthritis by modulating Th17/Treg imbalance in mice with curdlan-induced spondyloarthritis

Spondyloarthritis (SpA) is a systemic inflammatory arthritis mediated mainly by interleukin (IL)-17. The vitronectin-derived bioactive peptide, VnP-16, exerts an anti-osteoporotic effect via β1 and αvβ3 integrin signaling. SpA is associated with an increased risk of osteoporosis, and we investigated...

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Veröffentlicht in:	PloS one 2022-01, Vol.17 (1), p.e0262183-e0262183
Hauptverfasser:	Min, Hong Ki, Choi, JeongWon, Lee, Seon-Yeong, Lee, A Ram, Min, Byung-Moo, Cho, Mi-La, Park, Sung-Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis beta-Glucans - adverse effects Biological activity Biology and Life Sciences Biomedical materials Bisphosphonates Care and treatment Celecoxib Celecoxib - administration & dosage Celecoxib - pharmacology Cell differentiation Cytokines Cytokines - genetics Cytokines - metabolism Disease Models, Animal Disease Progression Female Flow cytometry Fractures Gene Expression Regulation - drug effects Glycoproteins Health aspects Health sciences Helper cells Humans IL-1β Inflammation Inflammatory diseases Integrin alphaVbeta3 - metabolism Integrin beta1 - metabolism Interleukin 17 Interleukin 6 Internal medicine Laboratory animals Lymphocytes Lymphocytes T Medical schools Medicine Medicine and Health Sciences Mice Mutation Osteoporosis Peptides Peptides - administration & dosage Peptides - pharmacology Prevention Research and Analysis Methods Rheumatic diseases Rheumatism Rheumatology Signal Transduction Spine Spleen Spleen - immunology Splenocytes Spondylarthritis - chemically induced Spondylarthritis - drug therapy Spondylarthritis - genetics Spondylarthritis - immunology Spondylitis Spondyloarthropathies Staining STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism T cells T-Lymphocytes, Regulatory - metabolism Testing Th17 Cells - metabolism Transcription Tumor necrosis factor-TNF Tumor necrosis factor-α Vitronectin Vitronectin - chemistry Western blotting
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