Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study
An association has been shown between functional abdominal pain disorders (FAPDs) and asthma. However, the exact reason for this association is obscured. The main objective of this study is to identify the possible underlying pathophysiological mechanisms for the association between FAPDs and asthma...
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| creator | Kumari, Manori Vijaya Amarasiri, Lakmali Rajindrajith, Shaman Devanarayana, Niranga Manjuri |
| description | An association has been shown between functional abdominal pain disorders (FAPDs) and asthma. However, the exact reason for this association is obscured. The main objective of this study is to identify the possible underlying pathophysiological mechanisms for the association between FAPDs and asthma using gastric motility and lung function tests.
This was a cross-sectional comparative study that consisted of four study groups. Twenty-four children (age 7-12 years) each were recruited for four study groups; asthma only, FAPDs only, both asthma and FAPDs, and healthy controls. Asthma was diagnosed using the history and bronchodilator reversibility test. The diagnosis of FAPDs was made using Rome IV criteria. All subjects underwent ultrasound assessment of gastric motility and pulmonary function assessment by spirometry, using validated techniques.
All gastric motility parameters, gastric emptying rate, amplitude of antral contraction, and antral motility index, were significantly impaired in children with FAPDs only, children with asthma only, and children with both asthma & FAPDs, compared to controls (p0.05), but significantly impaired in children with asthma and children with both disorders. Antral motility index correlated with the FEV1/FVC ratio (r = 0.60, p = 0.002) and FEF25%-75% (r = 0.49, p = 0.01) in children with both asthma and FAPDs.
Gastric motor functions were significantly impaired in children with asthma, children with FAPDs, and children with both disorders. Motility index, measuring overall gastric motor activity, showed a significant positive correlation with lung function parameters that measure airflow limitation. Therefore, these diseases might arise as a result of primary disturbance of smooth muscle activity in the airways and gastrointestinal wall, which could be a possible pathophysiological mechanism for this association between asthma and FAPDs. |
| doi_str_mv | 10.1371/journal.pone.0262086 |
| format | Article |
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This was a cross-sectional comparative study that consisted of four study groups. Twenty-four children (age 7-12 years) each were recruited for four study groups; asthma only, FAPDs only, both asthma and FAPDs, and healthy controls. Asthma was diagnosed using the history and bronchodilator reversibility test. The diagnosis of FAPDs was made using Rome IV criteria. All subjects underwent ultrasound assessment of gastric motility and pulmonary function assessment by spirometry, using validated techniques.
All gastric motility parameters, gastric emptying rate, amplitude of antral contraction, and antral motility index, were significantly impaired in children with FAPDs only, children with asthma only, and children with both asthma & FAPDs, compared to controls (p<0.05). Pulmonary function parameters indicating airway obstruction (FEV1/FVC ratio, peak expiratory flow rate, FEF25-75%) were not impaired in children with FAPDs only compared to controls (p>0.05), but significantly impaired in children with asthma and children with both disorders. Antral motility index correlated with the FEV1/FVC ratio (r = 0.60, p = 0.002) and FEF25%-75% (r = 0.49, p = 0.01) in children with both asthma and FAPDs.
Gastric motor functions were significantly impaired in children with asthma, children with FAPDs, and children with both disorders. Motility index, measuring overall gastric motor activity, showed a significant positive correlation with lung function parameters that measure airflow limitation. Therefore, these diseases might arise as a result of primary disturbance of smooth muscle activity in the airways and gastrointestinal wall, which could be a possible pathophysiological mechanism for this association between asthma and FAPDs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0262086</identifier><identifier>PMID: 34982797</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Abdominal Pain - diagnostic imaging ; Abdominal Pain - physiopathology ; Abdominal pain in children ; Air flow ; Asthma ; Asthma - diagnostic imaging ; Asthma - physiopathology ; Asthma in children ; Biology and Life Sciences ; Bronchodilators ; Case-Control Studies ; Child ; Children ; Comparative studies ; Complications and side effects ; Cross-Sectional Studies ; Disorders ; Ethics ; Female ; Flow velocity ; Forced Expiratory Volume ; Gastric Emptying ; Gastric motility ; Gastrointestinal system ; Humans ; Inflammation ; Irritable bowel syndrome ; Laboratories ; Lung - physiopathology ; Lungs ; Male ; Medicine ; Medicine and Health Sciences ; Motility ; Motor activity ; Muscle function ; Muscles ; Pain ; Parameters ; Pediatric research ; People and Places ; Physiological aspects ; Physiology ; Pulmonary functions ; Quality of life ; Research and Analysis Methods ; Respiratory function ; Respiratory Function Tests ; Risk factors ; Smooth muscle ; Spirometry ; Steroids ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>PloS one, 2022-01, Vol.17 (1), p.e0262086-e0262086</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Kumari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Kumari et al 2022 Kumari et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f512690090f83867799c983255c008f9398f6f6d8817aed61e788858ad4ebb003</citedby><cites>FETCH-LOGICAL-c692t-f512690090f83867799c983255c008f9398f6f6d8817aed61e788858ad4ebb003</cites><orcidid>0000-0002-2988-110X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726504/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726504/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34982797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Plavec, Davor</contributor><creatorcontrib>Kumari, Manori Vijaya</creatorcontrib><creatorcontrib>Amarasiri, Lakmali</creatorcontrib><creatorcontrib>Rajindrajith, Shaman</creatorcontrib><creatorcontrib>Devanarayana, Niranga Manjuri</creatorcontrib><title>Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>An association has been shown between functional abdominal pain disorders (FAPDs) and asthma. However, the exact reason for this association is obscured. The main objective of this study is to identify the possible underlying pathophysiological mechanisms for the association between FAPDs and asthma using gastric motility and lung function tests.
This was a cross-sectional comparative study that consisted of four study groups. Twenty-four children (age 7-12 years) each were recruited for four study groups; asthma only, FAPDs only, both asthma and FAPDs, and healthy controls. Asthma was diagnosed using the history and bronchodilator reversibility test. The diagnosis of FAPDs was made using Rome IV criteria. All subjects underwent ultrasound assessment of gastric motility and pulmonary function assessment by spirometry, using validated techniques.
All gastric motility parameters, gastric emptying rate, amplitude of antral contraction, and antral motility index, were significantly impaired in children with FAPDs only, children with asthma only, and children with both asthma & FAPDs, compared to controls (p<0.05). Pulmonary function parameters indicating airway obstruction (FEV1/FVC ratio, peak expiratory flow rate, FEF25-75%) were not impaired in children with FAPDs only compared to controls (p>0.05), but significantly impaired in children with asthma and children with both disorders. Antral motility index correlated with the FEV1/FVC ratio (r = 0.60, p = 0.002) and FEF25%-75% (r = 0.49, p = 0.01) in children with both asthma and FAPDs.
Gastric motor functions were significantly impaired in children with asthma, children with FAPDs, and children with both disorders. Motility index, measuring overall gastric motor activity, showed a significant positive correlation with lung function parameters that measure airflow limitation. Therefore, these diseases might arise as a result of primary disturbance of smooth muscle activity in the airways and gastrointestinal wall, which could be a possible pathophysiological mechanism for this association between asthma and FAPDs.</description><subject>Abdomen</subject><subject>Abdominal Pain - diagnostic imaging</subject><subject>Abdominal Pain - physiopathology</subject><subject>Abdominal pain in children</subject><subject>Air flow</subject><subject>Asthma</subject><subject>Asthma - diagnostic imaging</subject><subject>Asthma - physiopathology</subject><subject>Asthma in children</subject><subject>Biology and Life Sciences</subject><subject>Bronchodilators</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>Comparative studies</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>Disorders</subject><subject>Ethics</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Forced Expiratory Volume</subject><subject>Gastric Emptying</subject><subject>Gastric motility</subject><subject>Gastrointestinal system</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Irritable bowel syndrome</subject><subject>Laboratories</subject><subject>Lung - physiopathology</subject><subject>Lungs</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Motility</subject><subject>Motor activity</subject><subject>Muscle function</subject><subject>Muscles</subject><subject>Pain</subject><subject>Parameters</subject><subject>Pediatric research</subject><subject>People and Places</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Pulmonary functions</subject><subject>Quality of life</subject><subject>Research and Analysis Methods</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Risk 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumari, Manori Vijaya</au><au>Amarasiri, Lakmali</au><au>Rajindrajith, Shaman</au><au>Devanarayana, Niranga Manjuri</au><au>Plavec, Davor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-01-04</date><risdate>2022</risdate><volume>17</volume><issue>1</issue><spage>e0262086</spage><epage>e0262086</epage><pages>e0262086-e0262086</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An association has been shown between functional abdominal pain disorders (FAPDs) and asthma. However, the exact reason for this association is obscured. The main objective of this study is to identify the possible underlying pathophysiological mechanisms for the association between FAPDs and asthma using gastric motility and lung function tests.
This was a cross-sectional comparative study that consisted of four study groups. Twenty-four children (age 7-12 years) each were recruited for four study groups; asthma only, FAPDs only, both asthma and FAPDs, and healthy controls. Asthma was diagnosed using the history and bronchodilator reversibility test. The diagnosis of FAPDs was made using Rome IV criteria. All subjects underwent ultrasound assessment of gastric motility and pulmonary function assessment by spirometry, using validated techniques.
All gastric motility parameters, gastric emptying rate, amplitude of antral contraction, and antral motility index, were significantly impaired in children with FAPDs only, children with asthma only, and children with both asthma & FAPDs, compared to controls (p<0.05). Pulmonary function parameters indicating airway obstruction (FEV1/FVC ratio, peak expiratory flow rate, FEF25-75%) were not impaired in children with FAPDs only compared to controls (p>0.05), but significantly impaired in children with asthma and children with both disorders. Antral motility index correlated with the FEV1/FVC ratio (r = 0.60, p = 0.002) and FEF25%-75% (r = 0.49, p = 0.01) in children with both asthma and FAPDs.
Gastric motor functions were significantly impaired in children with asthma, children with FAPDs, and children with both disorders. Motility index, measuring overall gastric motor activity, showed a significant positive correlation with lung function parameters that measure airflow limitation. Therefore, these diseases might arise as a result of primary disturbance of smooth muscle activity in the airways and gastrointestinal wall, which could be a possible pathophysiological mechanism for this association between asthma and FAPDs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34982797</pmid><doi>10.1371/journal.pone.0262086</doi><tpages>e0262086</tpages><orcidid>https://orcid.org/0000-0002-2988-110X</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2616581711 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Abdominal Pain - diagnostic imaging Abdominal Pain - physiopathology Abdominal pain in children Air flow Asthma Asthma - diagnostic imaging Asthma - physiopathology Asthma in children Biology and Life Sciences Bronchodilators Case-Control Studies Child Children Comparative studies Complications and side effects Cross-Sectional Studies Disorders Ethics Female Flow velocity Forced Expiratory Volume Gastric Emptying Gastric motility Gastrointestinal system Humans Inflammation Irritable bowel syndrome Laboratories Lung - physiopathology Lungs Male Medicine Medicine and Health Sciences Motility Motor activity Muscle function Muscles Pain Parameters Pediatric research People and Places Physiological aspects Physiology Pulmonary functions Quality of life Research and Analysis Methods Respiratory function Respiratory Function Tests Risk factors Smooth muscle Spirometry Steroids Ultrasonic imaging Ultrasonography |
| title | Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T20%3A41%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastric%20motility%20and%20pulmonary%20function%20in%20children%20with%20functional%20abdominal%20pain%20disorders%20and%20asthma:%20A%20pathophysiological%20study&rft.jtitle=PloS%20one&rft.au=Kumari,%20Manori%20Vijaya&rft.date=2022-01-04&rft.volume=17&rft.issue=1&rft.spage=e0262086&rft.epage=e0262086&rft.pages=e0262086-e0262086&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0262086&rft_dat=%3Cgale_plos_%3EA688645179%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2616581711&rft_id=info:pmid/34982797&rft_galeid=A688645179&rft_doaj_id=oai_doaj_org_article_b41a48b0b4d648fc893eba0584d031ca&rfr_iscdi=true |