Survival outcomes in elderly Taiwanese women according to breast cancer subtype and lymph node status: A single-center retrospective study
This study aimed to determine the rates of overall survival and recurrence-free survival among elderly Taiwanese women (>65 years old) according to breast cancer subtype and lymph node status. We identified 554 eligible patients who were >65 years old and had been treated based on internationa...
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| Veröffentlicht in: | PloS one 2021-12, Vol.16 (12), p.e0261258-e0261258 |
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| creator | Lin, Kung-Hung Hsu, Huan-Ming Hsu, Kuo-Feng Chu, Chi-Hong Hong, Zhi-Jie Fu, Chun-Yu Chou, Yu-Ching Mehra, Golshan Dai, Ming-Shen Yu, Jyh-Cherng Liao, Guo-Shiou |
| description | This study aimed to determine the rates of overall survival and recurrence-free survival among elderly Taiwanese women (>65 years old) according to breast cancer subtype and lymph node status. We identified 554 eligible patients who were >65 years old and had been treated based on international recommendations at our center between June 2005 and June 2015. Patients with the luminal A subtype had the highest rates of overall survival (90.6%) and recurrence-free survival (97.0%), while the lowest overall survival rate was observed in those with the triple-negative subtype (81.3%) and the lowest recurrence-free survival rate was observed in those with the luminal B subtype (84.0%). Multivariate Cox proportional hazard analysis, using the luminal A subtype as the reference, revealed significant differences in recurrence-free survival among luminal B patients according to lymph node status. Among elderly Taiwanese women with breast cancer, the breast cancer subtype might help predict survival outcomes. The luminal B subtype was associated with poor recurrence-free survival, and lymph node status was useful for predicting recurrence-free survival in this subset of patients. |
| doi_str_mv | 10.1371/journal.pone.0261258 |
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We identified 554 eligible patients who were >65 years old and had been treated based on international recommendations at our center between June 2005 and June 2015. Patients with the luminal A subtype had the highest rates of overall survival (90.6%) and recurrence-free survival (97.0%), while the lowest overall survival rate was observed in those with the triple-negative subtype (81.3%) and the lowest recurrence-free survival rate was observed in those with the luminal B subtype (84.0%). Multivariate Cox proportional hazard analysis, using the luminal A subtype as the reference, revealed significant differences in recurrence-free survival among luminal B patients according to lymph node status. Among elderly Taiwanese women with breast cancer, the breast cancer subtype might help predict survival outcomes. The luminal B subtype was associated with poor recurrence-free survival, and lymph node status was useful for predicting recurrence-free survival in this subset of patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0261258</identifier><identifier>PMID: 34968382</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Aged patients ; Biology and Life Sciences ; Breast cancer ; Breast Neoplasms - pathology ; Cancer therapies ; Care and treatment ; Disease-Free Survival ; Electronic health records ; Endocrine therapy ; Female ; Hazard assessment ; Hospitals ; Humans ; Kaplan-Meier Estimate ; Lymph nodes ; Lymph Nodes - pathology ; Lymphatic system ; Mammography ; Mastectomy ; Medical diagnosis ; Medical prognosis ; Medical records ; Medicine and Health Sciences ; Multivariate Analysis ; Neoplasm Recurrence, Local - pathology ; Neuroendocrine tumors ; Older people ; Patient outcomes ; Radiation therapy ; Radio frequency identification ; Retrospective Studies ; Surgery ; Survival ; Survival Analysis ; Taiwan ; Womens health</subject><ispartof>PloS one, 2021-12, Vol.16 (12), p.e0261258-e0261258</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The luminal B subtype was associated with poor recurrence-free survival, and lymph node status was useful for predicting recurrence-free survival in this subset of patients.</description><subject>Age</subject><subject>Aged</subject><subject>Aged patients</subject><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Disease-Free Survival</subject><subject>Electronic health records</subject><subject>Endocrine therapy</subject><subject>Female</subject><subject>Hazard assessment</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic system</subject><subject>Mammography</subject><subject>Mastectomy</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine and Health Sciences</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neuroendocrine tumors</subject><subject>Older people</subject><subject>Patient outcomes</subject><subject>Radiation therapy</subject><subject>Radio frequency identification</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Taiwan</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99u0zAUxiMEYmPwBggsISG4aHHixHa4QKom_lSaNIkNbi3HOWldOXZnOx19BZ4al2ZTi3aBcuHI_p3PPt85J8te5niaE5Z_WLnBW2mma2dhiguaFxV_lJ3mNSkmtMDk8cH_SfYshBXGFeGUPs1OSFlTTnhxmv2-GvxGb6RBbojK9RCQtghMC95s0bXUt9JCAHSbjiySSjnfartA0aHGgwwRKWkVeBSGJm7XgKRtkdn26yWyrgUUooxD-IhmKKQwAxMFNibcQ_QurEFFvdlRQ7t9nj3ppAnwYlzPsh9fPl-ff5tcXH6dn88uJorWRZzkIGmncqgo6zhXBVZdQzpZSao6hjmmipGyqrjKm6KsCecl4U1dE1UCbWsO5Cx7vdddGxfEaGMQycGqZEVBykTM90Tr5Eqsve6l3wontfi74fxCSB-1MiBqXKoagFHoaIlbxhvCaFUVbUmSySxPWp_G24amh3aXvpfmSPT4xOqlWLiN4CxnNWdJ4N0o4N3NACGKXgcFxqTCuGH_7jrVGPOEvvkHfTi7kVrIlIC2nUv3qp2omFHOSeolhhM1fYBKXwu9VqnnOp32jwLeHwUkJsKvuJBDCGJ-9f3_2cufx-zbA3YJ0sRlcGaI2tlwDJZ7UKXOCh66e5NzLHYjc-eG2I2MGEcmhb06LNB90N2MkD_SKRLO</recordid><startdate>20211230</startdate><enddate>20211230</enddate><creator>Lin, Kung-Hung</creator><creator>Hsu, Huan-Ming</creator><creator>Hsu, Kuo-Feng</creator><creator>Chu, Chi-Hong</creator><creator>Hong, Zhi-Jie</creator><creator>Fu, Chun-Yu</creator><creator>Chou, Yu-Ching</creator><creator>Mehra, Golshan</creator><creator>Dai, Ming-Shen</creator><creator>Yu, Jyh-Cherng</creator><creator>Liao, Guo-Shiou</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1082-679X</orcidid></search><sort><creationdate>20211230</creationdate><title>Survival outcomes in elderly Taiwanese women according to breast cancer subtype and lymph node status: A single-center retrospective study</title><author>Lin, Kung-Hung ; Hsu, Huan-Ming ; Hsu, Kuo-Feng ; Chu, Chi-Hong ; Hong, Zhi-Jie ; Fu, Chun-Yu ; Chou, Yu-Ching ; Mehra, Golshan ; Dai, Ming-Shen ; Yu, Jyh-Cherng ; Liao, Guo-Shiou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1ea6fc1e567f88c20cfb3fa5a6cf70806c734558c1b249388438b993c4e6d98e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged patients</topic><topic>Biology and Life Sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - 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We identified 554 eligible patients who were >65 years old and had been treated based on international recommendations at our center between June 2005 and June 2015. Patients with the luminal A subtype had the highest rates of overall survival (90.6%) and recurrence-free survival (97.0%), while the lowest overall survival rate was observed in those with the triple-negative subtype (81.3%) and the lowest recurrence-free survival rate was observed in those with the luminal B subtype (84.0%). Multivariate Cox proportional hazard analysis, using the luminal A subtype as the reference, revealed significant differences in recurrence-free survival among luminal B patients according to lymph node status. Among elderly Taiwanese women with breast cancer, the breast cancer subtype might help predict survival outcomes. The luminal B subtype was associated with poor recurrence-free survival, and lymph node status was useful for predicting recurrence-free survival in this subset of patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34968382</pmid><doi>10.1371/journal.pone.0261258</doi><tpages>e0261258</tpages><orcidid>https://orcid.org/0000-0003-1082-679X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-12, Vol.16 (12), p.e0261258-e0261258 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; Public Library of Science (PLoS); DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Aged patients Biology and Life Sciences Breast cancer Breast Neoplasms - pathology Cancer therapies Care and treatment Disease-Free Survival Electronic health records Endocrine therapy Female Hazard assessment Hospitals Humans Kaplan-Meier Estimate Lymph nodes Lymph Nodes - pathology Lymphatic system Mammography Mastectomy Medical diagnosis Medical prognosis Medical records Medicine and Health Sciences Multivariate Analysis Neoplasm Recurrence, Local - pathology Neuroendocrine tumors Older people Patient outcomes Radiation therapy Radio frequency identification Retrospective Studies Surgery Survival Survival Analysis Taiwan Womens health |
| title | Survival outcomes in elderly Taiwanese women according to breast cancer subtype and lymph node status: A single-center retrospective study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A27%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Survival%20outcomes%20in%20elderly%20Taiwanese%20women%20according%20to%20breast%20cancer%20subtype%20and%20lymph%20node%20status:%20A%20single-center%20retrospective%20study&rft.jtitle=PloS%20one&rft.au=Lin,%20Kung-Hung&rft.date=2021-12-30&rft.volume=16&rft.issue=12&rft.spage=e0261258&rft.epage=e0261258&rft.pages=e0261258-e0261258&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0261258&rft_dat=%3Cgale_plos_%3EA688302670%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2615472234&rft_id=info:pmid/34968382&rft_galeid=A688302670&rft_doaj_id=oai_doaj_org_article_904c9ee76ef640d78b376552d4334971&rfr_iscdi=true |