Elevated serum expression of p53 and association of TP53 codon 72 polymorphisms with risk of cervical cancer in Bangladeshi women

Differential expression of p53 has been reported in cervical cancer, primarily in tumor tissue biopsies. In this study, we examined the association of TP53 codon 47 and codon 72 polymorphisms and serum level expression of p53 in cervical cancer patients (n = 129) and healthy controls (n = 122). We f...

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Veröffentlicht in:	PloS one 2021-12, Vol.16 (12), p.e0261984-e0261984
Hauptverfasser:	Mostaid, Md Shaki, Mumu, Sadia Biswas, Haque, Md Aminul, Sharmin, Shahana, Jamiruddin, Mohd Raeed, Sayedur Rahman, Ghazi Muhammad, Reza, Hasan Mahmud
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Antibodies Bangladesh - epidemiology Biology and Life Sciences Biomarkers Biopsy Cancer Case-Control Studies Cell cycle Cervical cancer Cervix Codon Female Genes, p53 Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotype Genotype & phenotype Health risks Heterozygosity Heterozygote Homozygosity Hospitals Humans Life sciences Linear Models Medical prognosis Medicine and Health Sciences Middle Aged Odds Ratio p53 Protein Pharmaceutical sciences Pharmacy Physical Sciences Polymorphism Polymorphism, Single Nucleotide Population Protein expression Proteins Quantitative Trait Loci Research and Analysis Methods Risk Risk Assessment Risk factors Single-nucleotide polymorphism Tumor proteins Tumor Suppressor Protein p53 - blood Tumors Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - genetics Womens health
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