A mathematical model for the dependence of keratin aggregate formation on the quantity of mutant keratin expressed in EGFP-K14 R125P keratinocytes

We examined keratin aggregate formation and the possible mechanisms involved. With this aim, we observed the effect that different ratios between mutant and wild-type keratins expressed in cultured keratinocytes may have on aggregate formation in vitro, as well as how keratin aggregate formation aff...

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Veröffentlicht in:	PloS one 2021-12, Vol.16 (12), p.e0261227-e0261227
Hauptverfasser:	Gouveia, Marcos, Sorčan, Tjaša, Zemljič-Jokhadar, Špela, Travasso, Rui D M, Liović, Mirjana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Analysis Biology and Life Sciences Cell culture Cell Line Cloning Computer Simulation Differential equations Filaments Fluorescent Dyes - chemistry Green Fluorescent Proteins - metabolism Humans Intermediate filaments Keratin Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Keratins - chemistry Mathematical analysis Mathematical models Mechanical properties Medicine and Health Sciences Models, Biological Mutant Proteins - chemistry Mutants Mutation Ordinary differential equations Physical Sciences Physics Properties Proteasome Inhibitors - pharmacology Protein Aggregates - drug effects Proteins Research and Analysis Methods Stiffness
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