Characterization of the adaptive immune response of donors receiving live anthrax vaccine
Live anthrax vaccine containing spores from attenuated strains STI-1 of Bacillus anthracis is used in Russia and former CIS (Commonwealth of Independent States) to prevent anthrax. In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (...
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| Veröffentlicht in: | PloS one 2021-12, Vol.16 (12), p.e0260202-e0260202 |
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| creator | Firstova, Victoria V Shakhova, Anastasia S Riabko, Alena K Silkina, Marina V Zeninskaya, Natalia A Romanenko, Yana O Marin, Maksim A Rogozin, Methun M Kartseva, Alena S Dyatlov, Ivan A Shemyakin, Igor G |
| description | Live anthrax vaccine containing spores from attenuated strains STI-1 of Bacillus anthracis is used in Russia and former CIS (Commonwealth of Independent States) to prevent anthrax. In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (PA), the lethal factor (LF) and their domains (D) in donors' blood at different times after their immunization with live anthrax vaccine. The relationship between the toxin neutralization activity level and the level of antibodies to PA, LF and their domains was tested. The effect of age, gender and number of vaccinations on the level of adaptive post-vaccination immune response has been studied. It was shown that antibodies against PA-D1 circulate in the blood of donors for 1 year or more after immunization with live anthrax vaccine. Antibodies against all domains of LF and PA-D4 were detected in 11 months after vaccination. Antibodies against the spores were detected in 8 months after vaccination. A moderate positive correlation was found between the titers of antibodies to PA, LF, or their domains, and the TNA of the samples of blood serum from the donors. |
| doi_str_mv | 10.1371/journal.pone.0260202 |
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In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (PA), the lethal factor (LF) and their domains (D) in donors' blood at different times after their immunization with live anthrax vaccine. The relationship between the toxin neutralization activity level and the level of antibodies to PA, LF and their domains was tested. The effect of age, gender and number of vaccinations on the level of adaptive post-vaccination immune response has been studied. It was shown that antibodies against PA-D1 circulate in the blood of donors for 1 year or more after immunization with live anthrax vaccine. Antibodies against all domains of LF and PA-D4 were detected in 11 months after vaccination. Antibodies against the spores were detected in 8 months after vaccination. A moderate positive correlation was found between the titers of antibodies to PA, LF, or their domains, and the TNA of the samples of blood serum from the donors.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0260202</identifier><identifier>PMID: 34928976</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptive Immunity ; Age factors ; Analysis ; Anthrax ; Anthrax - immunology ; Anthrax - prevention & control ; Anthrax vaccine ; Anthrax Vaccines - administration & dosage ; Anthrax Vaccines - immunology ; Antibodies ; Antibodies, Bacterial - blood ; Antibodies, Bacterial - immunology ; Antigens ; Antigens, Bacterial - immunology ; Bacterial Toxins - immunology ; Binding sites ; Biology and Life Sciences ; Biotechnology ; Blood ; Blood Donors ; Complications and side effects ; Domains ; Humans ; Immune response ; Immune system ; Immunization ; Kinases ; Laboratories ; Lethal factor ; Medicine and Health Sciences ; Molecular biology ; Neutralization ; Neutralization Tests ; Patient outcomes ; Protective antigen ; Proteins ; Russia ; Spores ; Spores, Bacterial - immunology ; Surveillance ; Toxins ; Vaccination ; Vaccines</subject><ispartof>PloS one, 2021-12, Vol.16 (12), p.e0260202-e0260202</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Firstova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Firstova et al 2021 Firstova et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c626t-d0c4785dfd68dbe50d9379ab0bad452bd846dd3e2b647594e86dd88a5a3549df3</citedby><cites>FETCH-LOGICAL-c626t-d0c4785dfd68dbe50d9379ab0bad452bd846dd3e2b647594e86dd88a5a3549df3</cites><orcidid>0000-0002-3159-6439 ; 0000-0001-7478-909X ; 0000-0003-0560-915X ; 0000-0002-2245-974X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687594/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687594/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34928976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Singh, Samer</contributor><creatorcontrib>Firstova, Victoria V</creatorcontrib><creatorcontrib>Shakhova, Anastasia S</creatorcontrib><creatorcontrib>Riabko, Alena K</creatorcontrib><creatorcontrib>Silkina, Marina V</creatorcontrib><creatorcontrib>Zeninskaya, Natalia A</creatorcontrib><creatorcontrib>Romanenko, Yana O</creatorcontrib><creatorcontrib>Marin, Maksim A</creatorcontrib><creatorcontrib>Rogozin, Methun M</creatorcontrib><creatorcontrib>Kartseva, Alena S</creatorcontrib><creatorcontrib>Dyatlov, Ivan A</creatorcontrib><creatorcontrib>Shemyakin, Igor G</creatorcontrib><title>Characterization of the adaptive immune response of donors receiving live anthrax vaccine</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Live anthrax vaccine containing spores from attenuated strains STI-1 of Bacillus anthracis is used in Russia and former CIS (Commonwealth of Independent States) to prevent anthrax. In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (PA), the lethal factor (LF) and their domains (D) in donors' blood at different times after their immunization with live anthrax vaccine. The relationship between the toxin neutralization activity level and the level of antibodies to PA, LF and their domains was tested. The effect of age, gender and number of vaccinations on the level of adaptive post-vaccination immune response has been studied. It was shown that antibodies against PA-D1 circulate in the blood of donors for 1 year or more after immunization with live anthrax vaccine. Antibodies against all domains of LF and PA-D4 were detected in 11 months after vaccination. Antibodies against the spores were detected in 8 months after vaccination. A moderate positive correlation was found between the titers of antibodies to PA, LF, or their domains, and the TNA of the samples of blood serum from the donors.</description><subject>Adaptive Immunity</subject><subject>Age factors</subject><subject>Analysis</subject><subject>Anthrax</subject><subject>Anthrax - immunology</subject><subject>Anthrax - prevention & control</subject><subject>Anthrax vaccine</subject><subject>Anthrax Vaccines - administration & dosage</subject><subject>Anthrax Vaccines - immunology</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antigens</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial Toxins - immunology</subject><subject>Binding sites</subject><subject>Biology and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>Blood Donors</subject><subject>Complications and side effects</subject><subject>Domains</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Lethal factor</subject><subject>Medicine and Health Sciences</subject><subject>Molecular biology</subject><subject>Neutralization</subject><subject>Neutralization Tests</subject><subject>Patient outcomes</subject><subject>Protective antigen</subject><subject>Proteins</subject><subject>Russia</subject><subject>Spores</subject><subject>Spores, Bacterial - 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In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (PA), the lethal factor (LF) and their domains (D) in donors' blood at different times after their immunization with live anthrax vaccine. The relationship between the toxin neutralization activity level and the level of antibodies to PA, LF and their domains was tested. The effect of age, gender and number of vaccinations on the level of adaptive post-vaccination immune response has been studied. It was shown that antibodies against PA-D1 circulate in the blood of donors for 1 year or more after immunization with live anthrax vaccine. Antibodies against all domains of LF and PA-D4 were detected in 11 months after vaccination. Antibodies against the spores were detected in 8 months after vaccination. 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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; EZB Free E-Journals; DOAJ Directory of Open Access Journals; PLoS - Public Library of Sciencem (Open Access); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adaptive Immunity Age factors Analysis Anthrax Anthrax - immunology Anthrax - prevention & control Anthrax vaccine Anthrax Vaccines - administration & dosage Anthrax Vaccines - immunology Antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antigens Antigens, Bacterial - immunology Bacterial Toxins - immunology Binding sites Biology and Life Sciences Biotechnology Blood Blood Donors Complications and side effects Domains Humans Immune response Immune system Immunization Kinases Laboratories Lethal factor Medicine and Health Sciences Molecular biology Neutralization Neutralization Tests Patient outcomes Protective antigen Proteins Russia Spores Spores, Bacterial - immunology Surveillance Toxins Vaccination Vaccines |
| title | Characterization of the adaptive immune response of donors receiving live anthrax vaccine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T07%3A17%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20the%20adaptive%20immune%20response%20of%20donors%20receiving%20live%20anthrax%20vaccine&rft.jtitle=PloS%20one&rft.au=Firstova,%20Victoria%20V&rft.date=2021-12-20&rft.volume=16&rft.issue=12&rft.spage=e0260202&rft.epage=e0260202&rft.pages=e0260202-e0260202&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0260202&rft_dat=%3Cgale_plos_%3EA687465071%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2612008849&rft_id=info:pmid/34928976&rft_galeid=A687465071&rfr_iscdi=true |