Computational redesign of a fluorogen activating protein with Rosetta

The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, each of them went through laborious cycles of in vitr...

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Veröffentlicht in:	PLoS computational biology 2021-11, Vol.17 (11), p.e1009555-e1009555
Hauptverfasser:	Bozhanova, Nina G, Harp, Joel M, Bender, Brian J, Gavrikov, Alexey S, Gorbachev, Dmitry A, Baranov, Mikhail S, Mercado, Christina B, Zhang, Xuan, Lukyanov, Konstantin A, Mishin, Alexander S, Meiler, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Binding Binding proteins Binding sites Biology and Life Sciences Boron Compounds - chemistry Chromophores Computational Biology Computer applications Crystallography, X-Ray Design Docking Drug Design Fluorescence Fluorescence microscopy Fluorescent Dyes - chemistry Fluorescent proteins Fluoroscopic imaging Genetic code HEK293 Cells Humans Image resolution Ligands Localization Luminescent Proteins - chemistry Luminescent Proteins - genetics Methods Microscopy, Fluorescence Models, Molecular Molecular Docking Simulation Mutation Performance enhancement Physical Sciences Protein Conformation Protein Engineering - methods Protein Engineering - statistics & numerical data Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Redesign Research and Analysis Methods Software
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