A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

Myofiber atrophy occurs with aging and in many diseases but the underlying mechanisms are incompletely understood. Here, we have used >1,100 muscle-targeted RNAi interventions to comprehensively assess the function of 447 transcription factors in the developmental growth of body wall skeletal mus...

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Veröffentlicht in:	PLoS genetics 2021-11, Vol.17 (11), p.e1009926-e1009926
Hauptverfasser:	Graca, Flavia A, Sheffield, Natalie, Puppa, Melissa, Finkelstein, David, Hunt, Liam C, Demontis, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aging Animals Animals, Genetically Modified - genetics Atrophy Biology and life sciences Body wall Chemical properties Disease Models, Animal DNA-Binding Proteins - genetics Drosophila Drosophila melanogaster - genetics Drosophila Proteins - genetics Embryonic Development - genetics Enzymes Gene expression Genetic aspects Genomes Glycogen Synthase Kinase 3 - genetics Glycolysis Glycolysis - genetics Humans Hypertrophy Identification and classification Insects Kinases Medicine and Health Sciences Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscular Atrophy - genetics Muscular Atrophy - pathology Musculoskeletal system Myofibrils - genetics Myofibrils - metabolism Phosphorylation Physiological aspects Protein synthesis Proteins Research and Analysis Methods RNA Interference RNA-mediated interference Skeletal muscle Transcription factors Transcription Factors - genetics
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