The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliomas also exhibit high levels of copy number alterat...

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Veröffentlicht in:	PLoS genetics 2021-11, Vol.17 (11), p.e1009868-e1009868
Hauptverfasser:	Bočkaj, Irena, Martini, Tosca E I, de Camargo Magalhães, Eduardo S, Bakker, Petra L, Meeuwsen-de Boer, Tiny G J, Armandari, Inna, Meuleman, Saskia L, Mondria, Marin T, Stok, Colin, Kok, Yannick P, Bakker, Bjorn, Wardenaar, René, Seiler, Jonas, Broekhuis, Mathilde J C, van den Bos, Hilda, Spierings, Diana C J, Ringnalda, Femke C A, Clevers, Hans, Schüller, Ulrich, van Vugt, Marcel A T M, Foijer, Floris, Bruggeman, Sophia W M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibiotics Antibodies Biology and life sciences Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Cancer Cell culture Child Chromatin Chromosomes Copy number Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA replication DNA Replication - genetics Evaluation Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomes Genomic Instability Genomics Glioma Glioma - genetics Glioma - pathology Glioma cells Gliomas Histone H3 Histones Histones - physiology Humans Identification and classification Medicine and Health Sciences Mitosis Mitosis - genetics Mutants Mutation Pediatrics Replication Stem cells Tumors
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